过渡金属催化杂原子α位C-C偶联反应研究
Transition Metal-Catalyzed Heterocyclic α-C-C Coupling Reactions
DOI: 10.12677/jocr.2026.141007, PDF,   
作者: 郎雨童：浙江师范大学化学与材料科学学院，浙江 金华
关键词: 金属偶联反应；立体选择性合成；有机催化；Metal-Mediated Coupling Reactions； Stereoselective Synthesis； Organic Catalysis
摘要: 有机分子中存在丰富的C(sp3)-H键，C(sp3)-H官能化反应是构建C-C键的有效方式。C(sp3)-H官能化反应可以改变有机分子的结构，从而改变化合反应的模式，缩短合成路线并提高原子经济性。在众多处于不同化学环境的C-H键中，杂原子α位的C(sp3)-H键因诱导效应使其相较于其他的C(sp3)-H键具有更高的反应活性，因此杂原子α位的C(sp3)-H键官能团化是一种非常实用的合成策略。本综述系统总结了近几年来过渡金属催化氮/氧杂原子α位C(sp3)-H键官能团化的研究进展。
Abstract: Organic molecules contain abundant C(sp3)-H bonds, and C(sp3)-H functionalization reactions serve as an effective approach for constructing C-C bonds. These reactions can alter the structure of organic molecules, thereby modifying reaction patterns, shortening synthetic routes, and enhancing atom economy. Among the diverse C-H bonds in different chemical environments, heteroatom-adjacent α-C(sp3)-H bonds exhibit higher reactivity due to inductive effects compared to other C(sp3)-H bonds. Consequently, functionalizing heteroatom-adjacent α-C(sp3)-H bonds bonds represents a highly practical synthetic strategy. This review systematically summarizes recent advances in transition-metal-catalyzed functionalization of α-position C(sp3)-H bonds in nitrogen/oxygen heteroatoms.
文章引用：郎雨童. 过渡金属催化杂原子α位C-C偶联反应研究[J]. 有机化学研究, 2026, 14(1): 74-85. https://doi.org/10.12677/jocr.2026.141007

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