维生素A与新生儿肠道菌群的联系
The Link between Vitamin A and the Neonatal Gut Microbiota
DOI: 10.12677/bp.2026.162008, PDF,   
作者: 王 雕, 尹 琦*：重庆医科大学公共卫生学院卫生检验教研室，重庆；陈 莉：重庆医科大学公共卫生学院环境与人类健康研究中心，重庆
关键词: 维生素A；肠道菌群；免疫机制；疾病防治；Vitamin A； Gut Microbiota； Immune Mechanisms； Disease Prevention and Treatment
摘要: 本文旨在综述VA与新生儿肠道菌群之间复杂的联系，探讨VA在维持肠道菌群平衡、促进肠道健康方面的作用机制，以及VA缺乏(VAD)对肠道菌群构成、功能和宿主健康的影响。通过梳理国内外相关研究成果，本文揭示了VA与肠道菌群之间的相互作用机制，为肠道疾病预防和治疗提供了新的视角和策略。
Abstract: This article aims to review the complex relationship between vitamin A (VA) and the neonatal gut microbiota, explore the mechanisms by which VA maintains gut microbiota balance and promotes intestinal health, and examine the effects of vitamin A deficiency (VAD) on the composition and function of the gut microbiota as well as host health. By synthesizing relevant research findings from both domestic and international sources, this article reveals the mechanisms of interaction between VA and the gut microbiota, providing new perspectives and strategies for the prevention and treatment of intestinal diseases.
文章引用：王雕, 陈莉, 尹琦. 维生素A与新生儿肠道菌群的联系[J]. 生物过程, 2026, 16(2): 63-70. https://doi.org/10.12677/bp.2026.162008

参考文献

[1] Zangari, A., Noviello, C., Nobile, S., et al. (2017) Surgical Management of Necrotizing Enterocolitis in an Incredibly Low Birth Weight Infant and Review of the Literature. Clinica Terapeutica, 168, e297-e299.
[2] Allendorf, A., Dewitz, R., Weber, J., Bakthiar, S., Schloesser, R. and Rolle, U. (2018) Necrotizing Enterocolitis as a Prognostic Factor for the Neurodevelopmental Outcome of Preterm Infants—Match Control Study after 2 Years. Journal of Pediatric Surgery, 53, 1573-1577. [Google Scholar] [CrossRef] [PubMed]
[3] Frost, B.L., Modi, B.P., Jaksic, T. and Caplan, M.S. (2017) New Medical and Surgical Insights into Neonatal Necrotizing Enterocolitis: A Review. JAMA Pediatrics, 171, 83-88. [Google Scholar] [CrossRef] [PubMed]
[4] Lounder, D.T., Khandelwal, P., Dandoy, C.E., Jodele, S., Grimley, M.S., Wallace, G., et al. (2017) Lower Levels of Vitamin A Are Associated with Increased Gastrointestinal Graft-versus-Host Disease in Children. Blood, 129, 2801-2807. [Google Scholar] [CrossRef] [PubMed]
[5] De Medeiros, P.H.Q.S., Pinto, D.V., De Almeida, J.Z., Rêgo, J.M.C., Rodrigues, F.A.P., Lima, A.Â.M., et al. (2018) Modulation of Intestinal Immune and Barrier Functions by Vitamin A: Implications for Current Understanding of Malnutrition and Enteric Infections in Children. Nutrients, 10, Article No. 1128. [Google Scholar] [CrossRef] [PubMed]
[6] Bakdash, G., Vogelpoel, L.T., van Capel, T.M., Kapsenberg, M.L. and de Jong, E.C. (2015) Retinoic Acid Primes Human Dendritic Cells to Induce Gut-Homing, IL-10-Producing Regulatory T Cells. Mucosal Immunology, 8, 265-278. [Google Scholar] [CrossRef] [PubMed]
[7] Honda, K. and Littman, D.R. (2016) The Microbiota in Adaptive Immune Homeostasis and Disease. Nature, 535, 75-84. [Google Scholar] [CrossRef] [PubMed]
[8] Uberos, J., Miras-Baldo, M., Jerez-Calero, A. and Narbona-López, E. (2014) Effectiveness of Vitamin A in the Prevention of Complications of Prematurity. Pediatrics & Neonatology, 55, 358-362. [Google Scholar] [CrossRef] [PubMed]
[9] Osanai, M., Nishikiori, N., Murata, M., Chiba, H., Kojima, T. and Sawada, N. (2007) Cellular Retinoic Acid Bioavailability Determines Epithelial Integrity: Role of Retinoic acid Receptor Alpha Agonists in Colitis. Molecular Pharmacology, 71, 250-258. [Google Scholar] [CrossRef] [PubMed]
[10] McDonald, S.L.R., Savy, M., Fulford, A.J.C., Kendall, L., Flanagan, K.L. and Prentice, A.M. (2014) A Double Blind Randomized Controlled Trial in Neonates to Determine the Effect of Vitamin A Supplementation on Immune Responses: The Gambia Protocol. BMC Pediatrics, 14, Article No. 92. [Google Scholar] [CrossRef] [PubMed]
[11] Agace, W.W. and Persson, E.K. (2012) How Vitamin A Metabolizing Dendritic Cells Are Generated in the Gut Mucosa. Trends in Immunology, 33, 42-48. [Google Scholar] [CrossRef] [PubMed]
[12] Kumar, A. and Anjankar, A. (2023) A Narrative Review of Vitamin A Supplementation in Preterm and Term Infants. Cureus, 15, e38152. [Google Scholar] [CrossRef] [PubMed]
[13] Scott, C.L., Aumeunier, A.M. and Mowat, A.M. (2011) Intestinal CD103+ Dendritic Cells: Master Regulators of Tolerance? Trends in Immunology, 32, 412-419. [Google Scholar] [CrossRef] [PubMed]
[14] Martin, J.C., Bériou, G., Heslan, M., Bossard, C., Jarry, A., Abidi, A., et al. (2016) IL-22BP Is Produced by Eosinophils in Human Gut and Blocks IL-22 Protective Actions during Colitis. Mucosal Immunology, 9, 539-549. [Google Scholar] [CrossRef] [PubMed]
[15] Martin, J.C., Bériou, G., Heslan, M., Chauvin, C., Utriainen, L., Aumeunier, A., et al. (2014) Interleukin-22 Binding Protein (IL-22BP) Is Constitutively Expressed by a Subset of Conventional Dendritic Cells and Is Strongly Induced by Retinoic Acid. Mucosal Immunology, 7, 101-113. [Google Scholar] [CrossRef] [PubMed]
[16] Spencer, S.P., Wilhelm, C., Yang, Q., Hall, J.A., Bouladoux, N., Boyd, A., et al. (2014) Adaptation of Innate Lymphoid Cells to a Micronutrient Deficiency Promotes Type 2 Barrier Immunity. Science, 343, 432-437. [Google Scholar] [CrossRef] [PubMed]
[17] Kim, C. (2008) Roles of Retinoic Acid in Induction of Immunity and Immune Tolerance. Endocrine‚ Metabolic & Immune Disorders—Drug Targets, 8, 289-294. [Google Scholar] [CrossRef] [PubMed]
[18] Huda, M.N., Ahmad, S.M., Kalanetra, K.M., Taft, D.H., Alam, M.J., Khanam, A., et al. (2019) Neonatal Vitamin A Supplementation and Vitamin a Status Are Associated with Gut Microbiome Composition in Bangladeshi Infants in Early Infancy and at 2 Years of Age. The Journal of Nutrition, 149, 1075-1088. [Google Scholar] [CrossRef] [PubMed]
[19] 候淑婷, 陆远, 赵霞. IgA介导黏膜免疫及调节肠道菌群参与儿童哮喘发病的研究进展[J]. 中国医药导报, 2021, 18(10): 31-34.
[20] Nakajima, A., Sasaki, T., Itoh, K., Kitahara, T., Takema, Y., Hiramatsu, K., et al. (2020) A Soluble Fiber Diet Increases Bacteroides Fragilis Group Abundance and Immunoglobulin A Production in the Gut. Applied and Environmental Microbiology, 86, e00267-20. [Google Scholar] [CrossRef] [PubMed]
[21] de Yébenes, V.G. and Ramiro, A.R. (2006) Activation-Induced Deaminase: Light and Dark Sides. Trends in Molecular Medicine, 12, 432-439. [Google Scholar] [CrossRef] [PubMed]
[22] Tyler, C.J., Guzman, M., Lundborg, L.R., et al. (2022) Antibody Secreting Cells Are Critically Dependent on Integrin α4β7/MAdCAM-1 for Intestinal Recruitment and Control of the Microbiota during Chronic Colitis. Mucosal Immunology, 15, 109-119. [Google Scholar] [CrossRef] [PubMed]
[23] Kubinak, J.L., Petersen, C., Stephens, W.Z., Soto, R., Bake, E., O’Connell, R.M., et al. (2015) MyD88 Signaling in T Cells Directs IgA-Mediated Control of the Microbiota to Promote Health. Cell Host & Microbe, 17, 153-163. [Google Scholar] [CrossRef] [PubMed]
[24] Gómez-Rodríguez, G., Amador-Licona, N., Daza-Benítez, L., Barbosa-Sabanero, G., Carballo-Magdaleno, D., Aguilar-Padilla, R., et al. (2019) Single Strain versus Multispecies Probiotic on Necrotizing Enterocolitis and Faecal IgA Levels in Very Low Birth Weight Preterm Neonates: A Randomized Clinical Trial. Pediatrics & Neonatology, 60, 564-569. [Google Scholar] [CrossRef] [PubMed]
[25] Zhang, X.-Y., Guan, S., Zhang, H.-F., Li, R.-Y. and Liu, Z.-M. (2018) Activation of PD-1 Protects Intestinal Immune Defense through IL-10/miR-155 Pathway after Intestinal Ischemia Reperfusion. Digestive Diseases and Sciences, 63, 3307-3316. [Google Scholar] [CrossRef] [PubMed]
[26] 潘鋆, 陈鸿鹄, 潘建平. 肠黏膜分泌型免疫球蛋白A产生机制研究进展[J]. 新乡医学院学报, 2011, 28(6): 773-775.
[27] Guo, J., Ren, C., Han, X., Huang, W., You, Y. and Zhan, J. (2021) Role of IgA in the Early-Life Establishment of the Gut Microbiota and Immunity: Implications for Constructing a Healthy Start. Gut Microbes, 13, Article ID: 1908101. [Google Scholar] [CrossRef] [PubMed]
[28] Planer, J.D., Peng, Y., Kau, A.L., Blanton, L.V., Ndao, I.M., Tarr, P.I., et al. (2016) Development of the Gut Microbiota and Mucosal IgA Responses in Twins and Gnotobiotic Mice. Nature, 534, 263-266. [Google Scholar] [CrossRef] [PubMed]
[29] Hapfelmeier, S., Lawson, M.A.E., Slack, E., Kirundi, J.K., Stoel, M., Heikenwalder, M., et al. (2010) Reversible Microbial Colonization of Germ-Free Mice Reveals the Dynamics of IgA Immune Responses. Science, 328, 1705-1709. [Google Scholar] [CrossRef] [PubMed]
[30] Jørgensen, S.F., Holm, K., Macpherson, M.E., Storm-Larsen, C., Kummen, M., Fevang, B., et al. (2019) Selective IgA Deficiency in Humans Is Associated with Reduced Gut Microbial Diversity. Journal of Allergy and Clinical Immunology, 143, 1969-1971.e11. [Google Scholar] [CrossRef] [PubMed]
[31] Huus, K.E., Petersen, C. and Finlay, B.B. (2021) Diversity and Dynamism of IgA-Microbiota Interactions. Nature Reviews Immunology, 21, 514-525. [Google Scholar] [CrossRef] [PubMed]
[32] Niño, D.F., Sodhi, C.P., Egan, C.E., Zhou, Q., Lin, J., Lu, P., et al. (2017) Retinoic Acid Improves Incidence and Severity of Necrotizing Enterocolitis by Lymphocyte Balance Restitution and Repopulation of LGR5+ Intestinal Stem Cells. Shock, 47, 22-32. [Google Scholar] [CrossRef] [PubMed]
[33] Erickson, I., Tung, J. and Schwartz, D.J. (2025) Consequences of Host-Microbiome Interactions in Preterm Infants. Infection and Immunity, 93, e00501-24. [Google Scholar] [CrossRef] [PubMed]
[34] van den Elsen, L.W.J., Rekima, A. and Verhasselt, V. (2019) Early-Life Nutrition and Gut Immune Development. In: Nestlé Nutrition Institute Workshop Series, S. Karger AG, 137-149. [Google Scholar] [CrossRef] [PubMed]
[35] 杨早娟, 易彬, 李建华, 等. 早产儿血清维生素A、D水平与坏死性小肠结肠炎的相关性[J]. 发育医学电子杂志, 2025, 13(5): 338-343.
[36] Choobdar, F.A., Ghassemzadeh, M., Aslanbeigi, F., Attarian, M., Robatmeili, L., Rahimian, H., Haghighi Aski, B. and Manafi Anari, A. (2022) Association of Lower Vitamin A Levels in Neonates and Their Mothers with Increased Risk of Neonatal Late-Onset Sepsis: A Case-Control Study. Journal of Mother and Child, 26, 78-86. [Google Scholar] [CrossRef] [PubMed]