抗精神病药物所致认知损害的中医药防治研究进展
Research Progress in Traditional Chinese Medicine for the Prevention and Treatment of Cognitive Impairment Induced by Antipsychotic Drugs
DOI: 10.12677/ijpn.2026.153008, PDF,   
作者: 王 朋：湖北中医药大学中医学院，湖北 武汉；正定二五六医院精神卫生中心心理二科，河北 石家庄；章程鹏*：湖北中医药大学中医学院，湖北 武汉；邢毛毛：河北省胸科医院神经内科，河北 石家庄；任 鹏：武警第一机动总队医院医学心理科，河北 保定；田 丽, 贾世惠：正定二五六医院精神卫生中心心理二科，河北 石家庄
关键词: 抗精神病药物；认知损害；中医药；作用机制；临床症状；研究进展；Antipsychotic Drugs； Cognitive Impairment； Traditional Chinese Medicine； Mechanism of Action； Clinical Symptoms； Research Progress
摘要: 抗精神病药物所致的认知损害，严重影响患者的生活质量，导致治疗依从性下降。中医药在干预认知损害领域展现出独特的理论优势和潜在的应用价值。本文详细阐述了药源性认知损害的药理学机制、临床症状以及中医药对AICI的认识和辩证思路。同时，探讨了中医药防治AICI的现代研究进展。传统中医药学基于其“痰浊蒙窍、肾精亏虚”的独特病机认识，提出了“涤痰开窍、补肾益智”等治疗法则，展现出巨大潜质。现代研究证实，中医药可通过上调BDNF、抗炎、抗氧化、调节神经递质等多种机制发挥神经保护和认知改善作用，为治疗AICI提供了新的思路和方法。
Abstract: Cognitive impairment caused by antipsychotic drugs significantly deteriorates patients’ quality of life and leads to a decline in treatment adherence. Traditional Chinese medicine (TCM) demonstrates unique theoretical advantages and potential application value in the field of cognitive impairment intervention. This article elaborates on the pharmacological mechanisms, clinical symptoms of drug-induced cognitive impairment, as well as TCM’s understanding and dialectical approaches toward Antipsychotic-Induced Cognitive Impairment (AICI). Additionally, it explores the modern research progress in TCM’s prevention and treatment of AICI. Based on its unique pathological understanding of “phlegm turbidity obscuring the orifices” and “kidney essence deficiency”, traditional Chinese medicine proposes therapeutic principles such as “resolving phlegm to restore mental clarity” and “tonifying the kidney to enhance intelligence”, showcasing tremendous potential. Modern studies have confirmed that TCM can exert neuroprotective and cognitive-improving effects through multiple mechanisms, including upregulating Brain-Derived Neurotrophic Factor (BDNF), anti-inflammatory actions, antioxidant effects, and neurotransmitter regulation, thereby providing novel approaches and methods for treating AICI.
文章引用：王朋, 章程鹏, 邢毛毛, 任鹏, 田丽, 贾世惠. 抗精神病药物所致认知损害的中医药防治研究进展[J]. 国际神经精神科学杂志, 2026, 15(3): 63-70. https://doi.org/10.12677/ijpn.2026.153008

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