乳腺癌相关成纤维细胞：乳腺癌治疗的新靶点
Breast Cancer-Associated Fibroblasts: A New Target for Breast Cancer Therapy
DOI: 10.12677/ACM.2019.94092, PDF,   
作者: 李俊杰, 李 卉, 龙启明：四川省肿瘤医院乳腺外科中心，四川 成都；杨 业：四川省肿瘤医院肿瘤内科，四川 成都
关键词: 乳腺癌；肿瘤相关成纤维细胞；肿瘤微环境；Breast Cancer； Cancer-Associated Fibroblasts； Tumor Microenvironment
摘要: 肿瘤微环境是由肿瘤细胞、肿瘤支持细胞、细胞基质、细胞因子等构成。其中肿瘤相关成纤维细胞(Cancer-Associated Fibroblasts, CAFs)在肿瘤微环境中含量最为丰富，其在肿瘤的形成、肿瘤血管生成、增殖、侵袭和转移等事件过程中起着重要作用。这促使一些研究人员对CAFs的分子和细胞特征进行研究，探索其在预防和治疗癌症方面的潜在应用。目前有大量关于CAFs的定义、起源以及其对肿瘤细胞的作用的研究。在此，本文总结了目前CAFs定义的分歧，来源的多样性，以及其在乳腺癌治疗中的可能机制,并对该领域未来研究方向做出了分析。
Abstract: Tumor microenvironment is composed of tumor cells, tumor supporting cells, cell matrix and cy-tokines. Among these, cancer-associated fibroblasts (CAFs) are the most abundant in tumor mi-croenvironment and play an important role in tumorigenesis, angiogenesis, proliferation, invasion and metastasis. This has prompted some researchers to study the molecular and cellular characteristics of CAFs and explore their potential applications in cancer prevention and treatment. There are a lot of studies on the definition, origin and effect of CAFs on cancer cells. In this paper, we summarize the differences in the definition of CAFs, the diversity of their sources, and the possible mechanisms in the treatment of breast cancer, and the future research directions in this field are also predicted.
文章引用：李俊杰, 李卉, 龙启明, 杨业. 乳腺癌相关成纤维细胞：乳腺癌治疗的新靶点[J]. 临床医学进展, 2019, 9(4): 606-612. https://doi.org/10.12677/ACM.2019.94092

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