非惊厥性癫痫持续状态诊断治疗方面的研究进展
Progress in the Diagnosis and Treatment of Non-Convulsive Status Epilepticus
摘要: 非惊厥性癫痫持续状态(NCSE)最初是在慢性癫痫患者中报道的,但目前发现在其他患者的群体中出现的频率也有所增加,尤其是在危重患者中。NCSE是指持续性脑电发作导致大非惊厥性临床症状,通常定义为> 30分钟。目前建议将持续时间的标准从30分钟缩短为5分钟。此外,有一点并不是很清楚,即脑电图上的电活动对临床损害或持续性的神经元损伤的影响程度如何。NSCE的诊断和治疗并不简单,取决于很多因素,包括临床背景、病因、EEG的结果和患者的临床状况。本文就近年来国内外对NCSE的诊断与治疗方面的研究进展进行综述。
Abstract: Non-convulsive status epilepticus (NCSE) was initially reported in patients with chronic seizures, but it has also been found to have increased frequency in other groups of patients, especially in critically ill patients. NCSE refers to large non-convulsive clinical symptoms caused by persistent EEG attacks, usually defined as >30 minutes. It is now recommended that the standard duration be reduced from 30 minutes to 5 minutes. In addition, it is not clear how much does electroencephalogram (EEG) electrical activity affect clinical damage or persistent neuronal injury. The diagnosis and treatment of NCE are not simple, depending on many factors, including clinical background, etiology, the results of EEG and the clinical status of the patients. In this paper, the research progress in the diagnosis and treatment of NCSE at home and abroad in recent years is reviewed.
文章引用:苗婵婵, 高学军. 非惊厥性癫痫持续状态诊断治疗方面的研究进展[J]. 国际神经精神科学杂志, 2019, 8(3): 25-29. https://doi.org/10.12677/IJPN.2019.83005

参考文献

[1] Oddo, M., Garrea, E., Claassen, J., et al. (2009) Continuouse Electroencephalography in the Medical Intensive Care Unit. Critical Care Medicine, 37, 2051-2056. [Google Scholar] [CrossRef
[2] Kurtz, P., Gaspard, N., Wahl, A.S., et al. (2014) Continuouse Electroencephalography in the Surgical Intensive Care Unit. Intensive Care Medicine, 40, 228-234. [Google Scholar] [CrossRef] [PubMed]
[3] Trinka, E., Cock, H., Hesdorffer, D., et al. (2015) A Definition and Classification of Status Epilepticus—Report of the ILAE Task Force on Classification of Status Epilepficus. Epilepsia, 56, 1515-1523. [Google Scholar] [CrossRef] [PubMed]
[4] Maganti, R., Gerber, P., Drees, C. and Chung, S. (2007) Nonconvulsive Status Epilepticus. Epilepsy and Behavior, 12, 572-586. [Google Scholar] [CrossRef] [PubMed]
[5] Payne, E.T., Zhao, X.Y., Frndova, H., et al. (2014) Seizure Burden Is Independently Associated with Short Term Outcome in Critically Ill Children. Brain, 137, 1429-1438. [Google Scholar] [CrossRef] [PubMed]
[6] Tu, T.M., Loh, N.K. and Tan, N.C. (2013) Clinical Risk Factors for Nonconvulsive Status Epilepticus during Emergent Electroencephalogram. Seizure, 22, 794-797. [Google Scholar] [CrossRef] [PubMed]
[7] Beniczky, S., Hirsch, L.J., Kaplan, P.W., et al. (2013) Unified EEG Terminology and Criteria for Nonconvulsive Status Epilepticus. Epilepsia, 54, 28-29. [Google Scholar] [CrossRef] [PubMed]
[8] 刘晓燕. 临床脑电图学[M]. 第2版. 北京: 人民卫生出版社, 2017: 301-302.
[9] Caseiato, S., Morano, A., Fattouch, J., et al. (2017) Ictal Pain in Focal Non-Convulsive Status Epilepticus. Practical Neurology, 17, 400-402. [Google Scholar] [CrossRef] [PubMed]
[10] Shahwan, A., Bailey, C., Shekerdemian, L. and Harvey, A.S. (2010) The Prevalence of Seizures in Comatose Children in the Pediatric Investive Care Unite: A Prospective Vedio-EEG Study. Epilepsia, 51, 1198-1204. [Google Scholar] [CrossRef] [PubMed]
[11] Kennedy, J.D. and Gerard, E.E. (2012) Continuous EGG Mon-itoring in the Intensive Care Unit. Current Neurology and Neuroscience Reports, 12, 419-428. [Google Scholar] [CrossRef] [PubMed]
[12] 王学峰. 神经系统发作性疾病与癫痫[M]. 北京: 人民卫生出版社, 2013: 30-33.
[13] 中国抗癫痫协会. 临床诊治指南癫痫病分册[M]. 第2版. 北京: 人民卫生出版社, 2015: 95.
[14] Yasiry, Z. and Shoron, S.D. (2014) The Relative Effectiveness of Five Antiepileptic Drugs in Treatment of Benzo-diazepine Resistant Convulsive Status Eplilepticus: A Meta-Analysis of Published Studies. Seizure, 23, 167-174. [Google Scholar] [CrossRef] [PubMed]
[15] Alvarez, V., Janeul, J.M., Burnand, B. and Rossetti, A.O. (2011) Second-Line Status Epilepticus Treatment: Comparison of Phenytoin, Valproate, and Levetiracetam. Epileasia, 52, 1292-1296. [Google Scholar] [CrossRef] [PubMed]
[16] Hofler, J. and Trinka, E. (2013) Lacosamide as a New Treatment Option in Status Epilepticus. Epileasia, 54, 393-404. [Google Scholar] [CrossRef] [PubMed]
[17] 孙一睿, 胡锦, 周良辅. 非惊厥性癫痫的诊断和治疗进展[J]. 国际神经病学神经外科学杂志, 2017, 44(3): 299-302.
[18] Glauser, T., Shinnar, S., Gloss, D., et al. (2016) Evidence-Based Guideline: Treatment of Convulsive Status Epilepticus in Children and Adults: Report of the Guideline Committee of the American Ep-ilepsy Society. Epilepsy Currents, 16, 48-61. [Google Scholar] [CrossRef] [PubMed]
[19] Holtkamp, M. and Meierkord, H. (2011) Nonconvulsive Status Epilepticus: A Diagnostic and Therapeutic Challenge in the Intensive Care Setting. Therapeutic Advances in Neurological Disorders, 4, 169-181. [Google Scholar] [CrossRef] [PubMed]