基于整合药理学探索大柴胡汤治疗肝癌的作用机制
Investigation in Molecular Mechanisms of Da-Chai-Hu-Tang in the Treatment of Hepatocellular Carcinoma by Integrated Pharmacology
DOI: 10.12677/TCM.2020.92011, PDF,    科研立项经费支持
作者: 许世豪, 李姚婷, 朱紫依, 崔文清, 沈凯凯：上海中医药大学基础医学院，上海
关键词: 大柴胡汤；肝癌；整合药理学；Da-Chai-Hu-Tang； Liver Cancer； Integrated Pharmacology
摘要: 目的：探析大柴胡汤防治肝癌的药效物质基础及其潜在作用机制。方法：运用中药整合药理学计算平台(TCMIP)，基于方剂、中药材、中药成分、疾病靶标四大数据库平台，从化学成分、疾病靶标预测、基因功能和通路富集分析大柴胡汤，建立“大柴胡汤–中药材–化学成分–靶标–信号通路–疾病”的可视化网络关系。结果：预测大柴胡汤抗肝癌主要活性成分138个，与肝癌发生发展过程相交互的靶标有51个，主要参与能量代谢、氨基酸合成转运、蛋白质翻译、脂质代谢、胆汁分泌、神经系统、嘌呤代谢、核苷酸代谢等作用机制。结论：本研究从多层次、多靶点、多角度阐述大柴胡汤防治肝癌的作用机制，为大柴胡汤防治肝癌临床运用提供理论依据，丰富中医复方研究的新思路。
Abstract: OBJECTIVE: To investigate the bioactive chemicals and mechanisms of Da-Chai-Hu-Tang in the treatment of liver cancer. METHOD: We applied the integrative pharmacology platform (TCMIP), combining with formulas, tr

上海人才发展资金；2019~2021年度中华中医药学会“青年人才托举工程”；上海中医药大学杏林学者。 aditional Chinese herbs, chemical compounds, and disease gene target to establish the pharmacological network of Da-Chai-Hu-Tang/traditional Chinese herbs/chemical compounds/gene target/signaling pathway/liver cancer. RESULTS: It predicts that 138 major bio-active ingredients from Da-Chai-Hu-Tang interact with 51 gene targets to treat liver cancer pro-gression. They are involved in processes of energy metabolism, amino acid synthesis and transport, protein translation, lipid metabolism, bile secretion, nervous system, purine metabolism, nucleotide metabolism, and etc. CONCLUSION: We explore the underlying mechanisms of Da-Chai-Hu-Tang in multiple ways, provide the theoretical support for the clinical application of Da-Chai-Hu-Tang in the treatment of liver cancer progression, and widen the horizon on how to explore mechanisms of traditional Chinese formula.

文章引用：许世豪, 李姚婷, 朱紫依, 崔文清, 沈凯凯. 基于整合药理学探索大柴胡汤治疗肝癌的作用机制[J]. 中医学, 2020, 9(2): 70-80. https://doi.org/10.12677/TCM.2020.92011

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