黄连素全合成综述
Summary of Total Synthesis of Berberine
DOI: 10.12677/HJCET.2020.104039, PDF,  被引量   
作者: 刘雪松：上海庚彩新材料科技有限公司，鞍山七彩化学股份有限公司上海研发中心，上海
关键词: 黄连素；全合成；抗菌；临床；Berberine； Total Synthesis； Antibacterial； Clinical
摘要: 黄连素亦称盐酸小檗碱，是从中药黄连等根茎中分离的一种季铵生物碱，也是黄连抗菌的主要有效成分。黄连素表现出十分广谱的生物活性，如抗感染、调节血脂、降血糖、降血压、增加胰岛素敏感性、抗心律失常、免疫调节、抗肿瘤等，在药物化学领域表现出十分广阔的应用前景。因而，关于黄连素和合成研究也引起了许多化学家的浓厚兴趣，本文系统地概括了近年来黄连素的合成研究进展。
Abstract: Berberine, also known as berberine hydrochloride, was isolated from the rhizomes of the Coptis chinensis plant Coptis chinensis. Berberine is an isoquinoline alkaloid bearing a quaternary ammonium group. Berberine shows a variety of biological activities, such as anti-infection, regulating blood lipids, lowering blood sugar, lowering blood pressure, increasing insulin sensitivity, anti-arrhythmia, immune regulation, anti-tumor etc. Therefore, many efforts have been made to improve the synthesis berberine. This review covers all recent advances achieved in the synthesis of berberine.
文章引用：刘雪松. 黄连素全合成综述[J]. 化学工程与技术, 2020, 10(4): 306-313. https://doi.org/10.12677/HJCET.2020.104039

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