慢性失眠共病OSAHS的研究进展
Progress in Study of Chronic Insomnia Comorbid Obstructive Sleep Apnea-Hypopnea Syndrome
DOI: 10.12677/IJPN.2021.102004, PDF,   
作者: 吕梦頔, 李 征, 薛 蓉*：天津医科大学总医院神经内科，天津；万亚会：天津医科大学总医院空港医院神经内科，天津
关键词: 慢性失眠；OSAHS；共病机制；睡眠结构；Chronic Insomnia； OSAHS； Comorbidity Mechanism； Sleep Structure
摘要: 在睡眠领域慢性失眠和阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea-hypopnea syn-drome, OSAHS)是最常见的两大类疾病，近年来研究发现慢性失眠和OSAHS相互作用影响，可引起更严重的睡眠结构紊乱、焦虑抑郁症状、认知功能下降和躯体化症状的发生，严重者会导致心脑血管疾病甚至猝死的发生，因此对慢性失眠共病OSAHS的及时筛查和诊治尤为必要，但由于两者的共病关系对治疗方案的选择成为了新的挑战，本综述对慢性失眠共病OSAHS的流行病学特点、共病影响机制、临床特征表现和治疗方案选择等方面进行阐述。
Abstract: Chronic insomnia and obstructive sleep apnea-hypopnea syndrome (OSAHS) are the two most common diseases in the field of sleep. In recent years, studies have found that the interaction be-tween chronic insomnia and OSAHS can cause more serious sleep structure disorders, anxiety and depression symptoms, cognitive decline and somatization symptoms. In severe cases, it can lead to cardiovascular and cerebrovascular diseases and even sudden death. Therefore, it is necessary to screen, diagnose and treat OSAHS in time, but because of the relationship between the two diseases, the choice of treatment options has become a new challenge. This review describes the epidemio-logical characteristics, comorbidity mechanism, clinical features and treatment options of chronic insomnia comorbid OSAHS.
文章引用：吕梦頔, 李征, 万亚会, 薛蓉. 慢性失眠共病OSAHS的研究进展[J]. 国际神经精神科学杂志, 2021, 10(2): 21-28. https://doi.org/10.12677/IJPN.2021.102004

参考文献

[1] Ito, E. and Inoue, Y. (2015) The International Classification of Sleep Disorders, Third Edition. American Academy of Sleep Medicine. Includes Bibliographies and Index. Nihon Rinsho, 73, 916-923.
[2] Javaheri, S. and Redline, S. (2017) Insomnia and Risk of Cardiovascular Disease. Chest, 152, 435-444. [Google Scholar] [CrossRef] [PubMed]
[3] Hong, S.O., Chen, Y.F., Jung, J., et al. (2017) Hypoglossal Nerve Stimulation for Treatment of Obstructive Sleep Apnea (OSA): A Primer for Oral and Maxillofacial Surgeons. Maxillofa-cial Plastic and Reconstructive Surgery, 39, 27. [Google Scholar] [CrossRef] [PubMed]
[4] Guilleminault, C., Eldridge, F.L. and Dement, W.C. (1973) In-somnia with Sleep Apnea: A New Syndrome. Science, 181, 856-858. [Google Scholar] [CrossRef] [PubMed]
[5] Glidewell, R.N., Renn, B.N., Roby, E., et al. (2014) Predictors and Patterns of Insomnia Symptoms in OSA before and after PAP Therapy. Sleep Medicine, 15, 899-905. [Google Scholar] [CrossRef] [PubMed]
[6] Krakow, B., Melendrez, D., Ferreira, E., et al. (2001) Prevalence of Insomnia Symptoms in Patients with Sleep-Disordered Breathing. Chest, 120, 1923-1929. [Google Scholar] [CrossRef] [PubMed]
[7] Ong, J.C. and Crisostomo, M.I. (2013) The More the Merrier? Working towards Multidisciplinary Management of Obstructive Sleep Apnea and Comorbid Insomnia. Journal of Clini-cal Psychology, 69, 1066-1077. [Google Scholar] [CrossRef] [PubMed]
[8] Zhang, Y., Ren, R., Lei, F., et al. (2019) Worldwide and Regional Preva-lence Rates of Co-Occurrence of Insomnia and Insomnia Symptoms with Obstructive Sleep Apnea: A Systematic Review and Meta-Analysis. Sleep Medicine Reviews, 45, 1-17. [Google Scholar] [CrossRef] [PubMed]
[9] Mysliwiec, V., Matsangas, P., Baxter, T., et al. (2014) Comorbid Insomnia and Obstructive Sleep Apnea in Military Personnel: Cor-relation with Polysomnographic Variables. Military Medicine, 179, 294-300. [Google Scholar] [CrossRef] 
[10] Philip, P., Bioulac, S., Altena, E., et al. (2018) Specific In-somnia Symptoms and Self-Efficacy Explain CPAP Compliance in a Sample of OSAS Patients. PLoS ONE, 13, e0195343. [Google Scholar] [CrossRef] [PubMed]
[11] Sweetman, A., Lack, L., Lambert, S., et al. (2017) Does Comorbid Obstructive Sleep Apnea Impair the Effectiveness of Cognitive and Behavioral Therapy for Insomnia? Sleep Medicine, 39, 38-46. [Google Scholar] [CrossRef] [PubMed]
[12] Leiter, J.C., Knuth, S.L. and Bartlett, D.J. (1985) The Effect of Sleep Deprivation on Activity of the Genioglossus Muscle. The American Review of Respiratory Disease, 132, 1242-1245.
[13] Bayliss, D.A., Viana, F., Talley, E.M., et al. (1997) Neuromodulation of Hypoglossal Motoneurons: Cellular and Developmental Mechanisms. Respiration Physiology, 110, 139-150. [Google Scholar] [CrossRef] 
[14] Osman, A.M., Carter, S.G., Carberry, J.C., et al. (2018) Ob-structive Sleep Apnea: Current Perspectives. Nature and Science of Sleep, 10, 21-34. [Google Scholar] [CrossRef] 
[15] Sweetman, A., Lack, L. and Bastien, C. (2019) Co-Morbid Insomnia and Sleep Apnea (COMISA): Prevalence, Consequences, Methodological Considerations, and Recent Randomized Con-trolled Trials. Brain Sciences, 9, 371. [Google Scholar] [CrossRef] [PubMed]
[16] Ratnavadivel, R., Chau, N., Stadler, D., et al. (2009) Marked Reduc-tion in Obstructive Sleep Apnea Severity in Slow Wave Sleep. Journal of Clinical Sleep Medicine, 5, 519-524. [Google Scholar] [CrossRef] 
[17] Gold, A.R., Gold, M.S., Harris, K.W., et al. (2008) Hypersomnolence, Insomnia and the Pathophysiology of Upper Airway Resistance Syndrome. Sleep Medicine, 9, 675-683. [Google Scholar] [CrossRef] [PubMed]
[18] Umlauf, M.G., Chasens, E.R., Greevy, R.A., et al. (2004) Ob-structive Sleep Apnea, Nocturia and Polyuria in Older Adults. Sleep, 27, 139-144. [Google Scholar] [CrossRef] [PubMed]
[19] Balbo, M., Leproult, R. and Van Cauter, E. (2010) Impact of Sleep and Its Disturbances on Hypothalamo-Pituitary-Adrenal Axis Activity. International Journal of Endocrinology, 2010, Article ID: 759234. [Google Scholar] [CrossRef] [PubMed]
[20] Chotinaiwattarakul, W., O’Brien, L.M., Fan, L., et al. (2009) Fatigue, Tiredness, and Lack of Energy Improve with Treatment for OSA. Journal of Clinical Sleep Medicine, 5, 222-227. [Google Scholar] [CrossRef] 
[21] Luyster, F.S., Buysse, D.J. and Strollo, P.J. (2010) Comorbid Insomnia and Obstructive Sleep Apnea: Challenges for Clinical Practice and Research. Journal of Clinical Sleep Medicine, 6, 196-204. [Google Scholar] [CrossRef] 
[22] Chung, K.F. (2005) Insomnia Subtypes and Their Relationships to Daytime Sleepiness in Patients with Obstructive Sleep Apnea. Respiration, 72, 460-465. [Google Scholar] [CrossRef] [PubMed]
[23] Bjornsdottir, E., Janson, C., Sigurdsson, J.F., et al. (2013) Symptoms of Insomnia among Patients with Obstructive Sleep Apnea before and after Two Years of Positive Airway Pressure Treat-ment. Sleep, 36, 1901-1909. [Google Scholar] [CrossRef] [PubMed]
[24] Gooneratne, N.S., Gehrman, P.R., Nkwuo, J.E., et al. (2006) Consequenc-es of Comorbid Insomnia Symptoms and Sleep-Related Breathing Disorder in Elderly Subjects. Archives of Internal Medicine, 166, 1732-1738. [Google Scholar] [CrossRef] [PubMed]
[25] Smith, S., Sullivan, K., Hopkins, W., et al. (2004) Frequency of Insomnia Report in Patients with Obstructive Sleep Apnoea Hypopnea Syndrome (OSAHS). Sleep Medicine, 5, 449-456. [Google Scholar] [CrossRef] [PubMed]
[26] Li, Z., Li, Y., Yang, L., et al. (2015) Characterization of Obstruc-tive Sleep Apnea in Patients with Insomnia across Gender and Age. Sleep and Breathing, 19, 723-727. [Google Scholar] [CrossRef] [PubMed]
[27] 雷飞, 任蓉, 杜丽娜, 等. 失眠合并阻塞性睡眠呼吸暂停低通气综合征患者的夜间睡眠图结构特征[J]. 华西医学, 2016, 31(8): 1321-1324.
[28] 叶静怡, 王彦婷, 毛丹丹, 等. 失眠伴阻塞性睡眠呼吸暂停患者睡眠特征结构分析[J]. 国际精神病学杂志, 2020, 47(5): 960-963.
[29] Wang, S.H., Chen, W.S., Tang, S.E., et al. (2018) Benzodiazepines Associated with Acute Respiratory Failure in Patients with Obstructive Sleep Apnea. Frontiers in Pharmacology, 9, 1513. [Google Scholar] [CrossRef] [PubMed]
[30] Drab, D.L. (2003) The Relationship between Obstructive Sleep Ap-nea Syndrome and Insomnia: Implications for Treatment.
[31] Wichniak, A., Wierzbicka, A., Walecka, M., et al. (2017) Effects of Antidepressants on Sleep. Current Psychiatry Reports, 19, 63. [Google Scholar] [CrossRef] [PubMed]
[32] Aloia, M.S. (2011) Understanding the Problem of Poor CPAP Adherence. Sleep Medicine Reviews, 15, 341-342. [Google Scholar] [CrossRef] [PubMed]
[33] Lettieri, C.J., Shah, A.A., Holley, A.B., et al. (2009) Effects of a Short Course of Eszopiclone on Continuous Positive Airway Pressure Adherence: A Randomized Trial. Annals of Inter-nal Medicine, 151, 696-702. [Google Scholar] [CrossRef] [PubMed]
[34] Ong, J.C., Crawford, M.R., Dawson, S.C., et al. (2020) A Randomized Controlled Trial of CBT-I and PAP for Obstructive Sleep Apnea and Comorbid Insomnia: Main Outcomes from the MATRICS Study. Sleep, 43, zsaa041. [Google Scholar] [CrossRef] [PubMed]
[35] Lack, L. and Sweetman, A. (2016) Diagnosis and Treatment of Insomnia Comorbid with Obstructive Sleep Apnea. Sleep Medicine Clinics, 11, 379-388. [Google Scholar] [CrossRef] [PubMed]
[36] Fung, C.H., Martin, J.L., Josephson, K., et al. (2016) Efficacy of Cognitive Behavioral Therapy for Insomnia in Older Adults with Occult Sleep-Disordered Breathing. Psychosomatic Medicine, 78, 629-639. [Google Scholar] [CrossRef] 
[37] Sweetman, A., Lack, L., McEvoy, R.D., et al. (2020) Cognitive Behavioural Therapy for İnsomnia Reduces Sleep Apnoea Severity: A Randomised Controlled Trial. ERJ Open Research, 6, 00161-2020. [Google Scholar] [CrossRef] [PubMed]