Semaphorin 3A与免疫细胞作用的研究进展
Research Progress on the Effect of Semaphorin 3A on Immune Cells
DOI: 10.12677/ACM.2021.119633, PDF,   
作者: 史卓雅：青海大学，青海 西宁；罗朋立：青海大学附属医院，青海 西宁
关键词: Semaphorin 3A；免疫细胞；调控作用；Semaphorin 3A； Immune Cells； Regulation
摘要: Semaphorins是一个庞大的分泌和膜结合蛋白家族。最近发现，Semaphorins参与了免疫系统的调控作用。一些Semaphorins及其受体在各种免疫细胞中表达，并影响免疫细胞的功能，包括细胞激活、增殖、迁移和凋亡。Semaphorin 3A (Sema 3A)是Sema家族的一个分泌型成员，在免疫应答的各个阶段都有很强的免疫调节作用，Sema 3A在骨、结缔组织、肾脏、神经元和软骨中广泛表达。本文主要对近年来Sema 3A对主要免疫细胞的作用研究进展进行综述。
Abstract: Semaphorins are a large family of secretory and membrane-bound proteins. It was recently discovered that Semaphorins are involved in the regulation of the immune system. Some Semaphorins and their receptors are expressed in various immune cells and affect the functions of immune cells, including cell activation, proliferation, migration and apoptosis. Semaphorin 3A (Sema 3A) is a secretory member of the Sema family. It has a strong immunomodulatory effect at all stages of the immune response. Sema 3A is widely expressed in bone, connective tissue, kidney, neurons and cartilage. This article mainly reviews the research progress of Sema 3A’s effect on main immune cells in recent years.
文章引用：史卓雅, 罗朋立. Semaphorin 3A与免疫细胞作用的研究进展[J]. 临床医学进展, 2021, 11(9): 4326-4331. https://doi.org/10.12677/ACM.2021.119633

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