骨折断端初次血肿成骨能力的研究进展

Research Progress on Osteogenesis Ability of Primary Hematoma at Fracture End

摘要: 骨折延迟愈合或骨不连仍是现在骨折愈合的一大问题，骨折发生时可在短时间内形成初次血肿，目前研究认为骨折初次血肿包含成骨潜力、介导相关免疫细胞生成，并且形成促进骨折愈合的一些诱导分子。国内学者较多对骨折初次血肿进行临床应用，而国外学者则多对其进行成分及机制研究，认为骨折初次血肿是骨折愈合的启动因素，它包含成骨潜力、介导相关免疫细胞生成，并且形成促进骨折愈合的一些诱导分子。本文综述了骨折部位初次血肿的临床应用及促进骨折愈合的相关成分及机制。

Abstract: Delayed fracture union or nonunion is still a major problem in fracture union. Primary hematoma can be formed in a short time when fracture occurs. Current studies suggest that primary fracture hematoma contains osteogenic potential, mediates related immune cell generation, and forms some inducing molecules that promote fracture union. Domestic scholars mostly carried out clinical application of primary fracture hematoma, while foreign scholars mostly studied its components and mechanism, believing that primary fracture hematoma is the initiating factor of fracture healing, which contains osteogenesis potential, mediates the generation of relevant immune cells, and forms some inducing molecules that promote fracture healing. This article reviews the clinical application of primary hematoma at fracture site and the related components and mechanisms of promoting fracture healing.