他汀类药物在慢性阻塞性肺疾病中的应用
Application of Statins in Chronic Obstructive Pulmonary Disease
摘要: 慢性阻塞性肺疾病(Chronic obstructive pulmonary disease, COPD)是以持续存在的呼吸道症状和气流受限为特征的可以预防和治疗的常见疾病。慢阻肺患者存在肺部和全身性的炎症。他汀类药物是降低血清胆固醇水平的常用药，目前已证实其除降脂效应以外，还有抗炎、抗氧化应激等多效性。目前已有大量临床研究探讨他汀类药物在慢性阻塞性肺疾病中的有益作用，以及他汀类在一些小鼠的动物实验中观察到了对香烟刺激所引起的肺气肿的改善。本文将对他汀类药物在慢阻肺及相关疾病中的有益影响作一综述。
Abstract: Chronic obstructive pulmonary disease (COPD) is a common preventable and therapeutic disease characterized by persistent respiratory symptoms and limited airflow. Patients with COPD have both lung and systemic inflammation. Statins are common drugs to reduce serum cholesterol levels, and it has been confirmed that in addition to the lipid reduction effect, they are also anti-inflammatory and anti-oxidative stress. A number of clinical studies have explored the beneficial role of statins in chronic obstructive pulmonary disease and the improvement in emphysema caused by cigarette stimulation observed in animal experiments in some mice. This paper reviews the beneficial effects of statins in COPD and related diseases.
文章引用：门凯, 张彩莲. 他汀类药物在慢性阻塞性肺疾病中的应用[J]. 临床医学进展, 2021, 11(12): 6183-6188. https://doi.org/10.12677/ACM.2021.1112917

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