LncRNA FTX在肿瘤中的研究进展
Research Progress of LncRNA FTX in Tumor
DOI: 10.12677/ACM.2022.122165, PDF,    国家自然科学基金支持
作者: 阮 邓*, 杜振宗#：桂林医学院，广西 桂林
关键词: LncRNA；肿瘤；肺癌；结肠癌；骨肉瘤；胃癌；肝癌；胰腺癌；Long Non-Coding RNA； Cancer； Lung Cancer； Colorectal Cancer； Osteosarcoma； Gastric Cancer； Liver Cancer； Pancreatic Cancer
摘要: LncRNA是一种长链非编码RNA，长度超过200个核苷酸，近些年关于lncRNA的研究也越来越多，虽然不能编码蛋白质，但也参与众多生物学功能，包括染色体修饰、基因组修饰、转录激活、转录干扰等过程。FTX是处于X染色体失活起始的重要调控因子Xist的5’端一个功能未知的基因，大量研究发现lncRNA FTX调控肿瘤细胞的迁移、侵袭和生长，因此探索lncRNA FTX对肿瘤的调控作用及其机制，对早期诊断、肿瘤治疗以及预后判断都有重要意义。本综述就lncRNA FTX在肺癌、结肠癌、骨肉瘤、胃癌、肝癌和胰腺癌中的作用及相关机制的研究进展作一综述。
Abstract: LncRNA is a long-chain non-coding RNA with a length of more than 200 bp. In recent years, there have been more and more studies on lncRNA. Although it can not encode a protein, it is also involved in many biological functions, including chromosome modification, genome modification, transcriptional activation, transcriptional interference and so on. FTX is a gene whose function is unknown at the 5’ end of Xist, an important regulatory factor at the initiation of X chromosome inactivation. A large number of studies have found that lncRNA FTX regulates the migration, invasion and growth of tumor cells, so exploring the regulatory effect of lncRNA FTX on tumor and its mechanism is of great significance for early diagnosis, tumor treatment and prognosis. This review reviews the role and related mechanisms of lncRNA FTX in lung cancer, colon cancer, osteosarcoma, gastric cancer, liver cancer and pancreatic cancer.
文章引用：阮邓, 杜振宗. LncRNA FTX在肿瘤中的研究进展[J]. 临床医学进展, 2022, 12(2): 1135-1141. https://doi.org/10.12677/ACM.2022.122165

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