HLA表达与女性妊娠相关疾病的研究进展
Research Progress of HLA Expression and Pregnancy-Related Diseases in Women
DOI: 10.12677/ACM.2022.122169, PDF,   
作者: 赵 睿:延安大学附属医院妇产科,陕西 延安;李 丽*:延安大学附属医院产科一病区,陕西 延安
关键词: HLA胚胎发育复发性流产IVF-ET妊娠期高血压疾病HLA Embryonic Development Recurrent Spontaneous Abortion IVF-ET Hypertensive Disorder Complicating Pregnancy
摘要: 育龄期女性的妊娠过程是一段非常重要且特殊的时期,对女性个人而言,不仅会发生复杂的生理改变,而且心理上也应作出一定调整以适应整个妊娠过程。同时就整个家族而言这也是一个意义非凡的阶段,从备孕至产褥期结束,平稳顺利的妊娠过程将会为整个家族减轻很多烦恼,反之,不孕、流产及各种妊娠期并发症等状况的发生则会带来极大的困扰以及经济、心理压力等。因而研究与女性妊娠相关疾病的发病及疾病演进机制,寻求诊断和治疗疾病的根本途径,以期减少整个过程中的不良结局发生也就变得尤为重要。
Abstract: The pregnancy process of women of childbearing age is a very important and special period. For women personally, not only complex physiological changes will occur, but also psychological adjustments should be made to adapt to the whole pregnancy process. At the same time, it is also a significant stage for the whole family. From the preparation of pregnancy to the end of puerperium, a smooth pregnancy process will reduce a lot of troubles for the whole family. On the contrary, the occurrence of infertility, abortion and various pregnancy complications will bring great troubles as well as economic and psychological pressure. Therefore, it is particularly important to study the pathogenesis and disease evolution mechanism of female pregnancy related diseases, and seek the fundamental way to diagnose and treat diseases in order to reduce the occurrence of adverse outcomes in the whole process.
文章引用:赵睿, 李丽. HLA表达与女性妊娠相关疾病的研究进展[J]. 临床医学进展, 2022, 12(2): 1165-1168. https://doi.org/10.12677/ACM.2022.122169

参考文献

[1] 崔桂玉, 白剑, 苗兰英, 林大勇, 刘鸿, 李亚丽, 刘喜成. HLA-G阳性的胎盘间充质干细胞体外诱导Treg的实验研究[J]. 中国应用生理学杂志, 2018, 34(5): 396-400.
[2] Morandi, F., Rizzo, R., Fainardi, E., Rouas-Freiss, N. and Pistoia, V. (2016) Recent Advances in Our Understanding of HLA-G Biology: Lessons from a Wide Spectrum of Human Diseases. Journal of Immunology Research, 2016, Article ID: 4326495. [Google Scholar] [CrossRef] [PubMed]
[3] Djurisic, S., Skibsted, L. and Hviid, T. (2015) A Phenotypic Analysis of Regulatory T Cells and Uterine NK Cells from First Trimester Pregnancies and Associations with HLA-G. American Journal of Reproductive Immunology (New York, NY: 1989), 74, 427-444. [Google Scholar] [CrossRef] [PubMed]
[4] Fu, B., Zhou, Y., Ni, X., Tong, X., Xu, X., Dong, Z., Sun, R., Tian, Z. and Wei, H. (2017) Natural Killer Cells Promote Fetal Development through the Secretion of Growth-Promoting Factors. Immunity, 47, 1100-1113.E6. [Google Scholar] [CrossRef] [PubMed]
[5] 乔宠, 王婷婷. 母胎免疫调节机制的研究进展[J]. 山东大学学报(医学版), 2021, 59(8): 24-31.
[6] 苏亚芳. 复发性流产的病因分析及治疗新进展[J]. 世界最新医学信息文摘, 2019, 19(58): 43-44.
[7] Rogenhofer, N., Toth, B., Kiessig, S., Hellstern, P., Taborski, U., Scholz, S. and Thaler, C.J. (2008) Enzyme Linked Immunosorbent Assay (ELISA) as Screening Method for Anti-Paternal Allo-Antibodies in Patients with Recurrent Pregnancy Loss (RPL). European Journal of Obstetrics & Gynecology and Reproductive Biology, 136, 155-159. [Google Scholar] [CrossRef] [PubMed]
[8] 李婷, 朱爱珍, 王雪松, 李晓霞, 康亚妮. 血清ACA、sHLA-G等在预测习惯性流产中的应用价值[J]. 中华保健医学杂志, 2017, 19(1): 40-42.
[9] 姚辰希. HLA抗体与妊娠的相关研究[D]: [硕士学位论文]. 天津: 天津医科大学, 2018.
[10] Yazdani, N., Khaniani, M.S., Bastami, M., Ghasemnejad, T., Afkhami, F. and Derakhshan, S.M. (2018) HLA-G Regulatory Variants and Haplotypes with Susceptibility to Recurrent Pregnancy Loss. International Journal of Immunogenetics, 45, 181-189. [Google Scholar] [CrossRef] [PubMed]
[11] Niu, Z., Wang, L., Pang, R., Guo, Y., Yeung, W. and Yao, Y. (2017) A Meta-Analysis of the Impact of Human Leukocyte Antigen-G on the Outcomes of IVF/ICSI. Reproductive Biomedicine Online, 34, 611-618. [Google Scholar] [CrossRef] [PubMed]
[12] 罗平, 沈开元, 卢娜, 罗江霞, 黄芬, 刘刚毅. 体外受精-胚胎移植(IVF-ET)胚胎培养液中HLA-G检测在预测胚胎发育潜能和临床结局中的应用价值研究[J]. 现代检验医学杂志, 2020, 35(6): 163-166+186.
[13] Marozio, L., Garofalo, A., Berchialla, P., Tavella, A., Salton, L., Cavallo, F. and Benedetto, C. (2017) Low Expression of Soluble Human Leukocyte Antigen G in Early Gestation and Subsequent Placenta-Mediated Complications of Pregnancy. The Journal of Obstetrics and Gynaecology Research, 43, 1391-1396. [Google Scholar] [CrossRef] [PubMed]
[14] 周静, 欧荣英, 周美茜, 林峰. 妊娠期高血压胎盘组织HLA-I类分子的表达意义及其与妊娠结局的关系[J]. 中华全科医学, 2018, 16(10): 5.