电化学催化1,4-萘醌的双官能团化反应构建碘代氨基萘醌化合物
Synthesis of Iodoaminonaphthoquinone Compounds by Electrochemically Catalyzed Bifunctionalization of 1,4-Naphthoquinone
DOI: 10.12677/HJCET.2022.123027, PDF,   
作者: 徐 雪, 何永辉*：云南民族大学民族医药学院，云南 昆明
关键词: 1¸4萘醌；双官能团化；电催化；1¸4-Naphthoquinone； Bifunctionalization； Electrocatalysis
摘要: 氨基萘醌类化合物是一类具有重要生理活性的杂环化合物，广泛存在于天然产物的结构中。因此，高效构建该类化合物具有重要的意义。本文以碘化钠为媒介，在电化学条件下实现了1,4萘醌的双官能团化反应，以33%~70%的收率得到了8种含不同取代基的碘代氨基萘醌类化合物，并通过自由基捕获实验验证该反应可能涉及自由基机理。
Abstract: Aminonaphthoquinones widely exist in natural products and have good biological activities. The synthesis of this kind of compounds has always been a hotspot for scientists. In this work, iodoaminonaphthoquinones with different substituents were synthesized by the bifunctionalization of 1,4-naphthoquinone in the medium of sodium iodide under electrochemical conditions. Through oxidation additions, eight iodoaminonaphthoquinones with different substituents were synthesized in 33%~70% yield under the optimal conditions. The free radical capture experiment verified that the reaction may involve the free radical mechanism.
文章引用：徐雪, 何永辉. 电化学催化1,4-萘醌的双官能团化反应构建碘代氨基萘醌化合物[J]. 化学工程与技术, 2022, 12(3): 194-200. https://doi.org/10.12677/HJCET.2022.123027

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