1例子宫炎性肌纤维母细胞瘤病例介绍
A Case of Uterine Inflammatory Myofibroblastic Tumor
DOI: 10.12677/ACM.2022.126721, PDF,   
作者: 张 艳, 徐胜凤, 孙小绘：西安医学院，陕西 西安；董 晋*：西北妇女儿童医院，陕西 西安
关键词: 子宫炎性肌纤维母细胞瘤；肿瘤；诊断；治疗；Uterine Inflammatory Myofibroblastic Tumor； Tumor； Diagnosis； Treatment
摘要: 炎性肌纤维母细胞瘤(inflammatory myofibroblastic tumor，IMT)是一种罕见的低恶性潜能的梭形细胞肿瘤，由分化的肌纤维母细胞梭形细胞和大量浆细胞和(或)淋巴细胞细胞组成。病因尚不清楚，可能诱因有特殊细菌或EB病毒感染、手术、损伤、炎症、异常修复、染色体畸变等。最常发生的部位是肺、肠系膜、大网膜和腹膜后。子宫炎性肌纤维母细胞瘤较少发生。免疫组织化学检测ALK表达和/或荧光原位杂交(FISH)检测ALK重排是炎性肌纤维母细胞瘤的诊断依据。本病首选手术治疗，通过手术完全切除病灶，大部分患者可治愈，但有复发、恶变、转移甚至致死可能。作为妇产科医生应该了解这种肿瘤并知道如何处理它。
Abstract: Inflammatory myofibroblastic tumor (IMT) is a rare spindle cell neoplasm with low malignant po-tential, and it is composed of proliferative myofibroblasts and mixed inflammatory cell infiltrate. The cause is not clear, but it may be caused by special bacteria or EB virus infection, operation, in-jury, inflammation, abnormal repair, chromosome aberration. IMT may arise in multiple organs, most commonly lungs, mesentery, omentum, and retroperitoneum. Rarely IMT arise in the uterus. ALK expression by immuno-histochemistry and/or ALK rearrangement by fluorescence in situ hy-bridization (FISH) are diagnostic of IMT. The first choice for surgical treatment of this disease, through surgical complete removal of the focus, most of the patients can be cured, but there are re-currence, malignant transformation, metastasis and even death. As an obstetrician and gynecologist, you should understand this tumor and know how to deal with it.
文章引用：张艳, 董晋, 徐胜凤, 孙小绘. 1例子宫炎性肌纤维母细胞瘤病例介绍[J]. 临床医学进展, 2022, 12(6): 4978-4982. https://doi.org/10.12677/ACM.2022.126721

参考文献

[1] Haimes, J.D., Stewart, C.J.R., Kudlow, B.A., et al. (2017) Uterine Inflammatory Myofibroblastic Tumors Frequently Harbor ALK Fusions with IGFBP5 and THBS1. The American Journal of Surgical Pathology, 41, 773-780. [Google Scholar] [CrossRef] 
[2] Rabban, J.T., Zaloudek, C., Shekitka, K.M., et al. (2005) In-flammatory Myofibroblastic Tumor of the Uterus: A Clinicopathologic Study of 6 Cases Emphasizing Distinction from Aggressive Mesenchymal Tumors. The American Journal of Surgical Pathology, 29, 1348-1355. [Google Scholar] [CrossRef] [PubMed]
[3] Bahadori, M. and Liebow, A.A. (1973) Plasma Cell Granulomas of the Lung. Cancer, 31, 191-208. [Google Scholar] [CrossRef] 
[4] Gilks, C., Tay-lor, G. and Clement, P. (1987) Inflammatory Pseudotumor of the Uterus. International Journal of Gynecological Pa-thology, 6, 275-286. [Google Scholar] [CrossRef] [PubMed]
[5] Olgan, S., Saatli, B. and Okyay, R.E. (2011) Hysteroscopic Excision of Inflammatory Myofibroblastic Tumor of the Uterus: As Case Report and Brief Review. European Journal of Obstetrics & Gynecology and Reproductive Biology, 157, 234-236. [Google Scholar] [CrossRef] [PubMed]
[6] Butrynski, J.E., D’Adamo, D.R., Hornick, J.L., et al. (2010) Crizotinib in ALK-Rearranged Inflammatory Myofibroblastic Tumor. The New England Journal of Medicine, 363, 1727-1733. [Google Scholar] [CrossRef] 
[7] Shintaku, M. and Fukushima, A. (2006) Inflammatory Myofibroblastic Tumor of the Uterus with Prominent Myxoid Change. Pathology International, 56, 625-628. [Google Scholar] [CrossRef] [PubMed]
[8] Parra-Herran, C., Quick, C.M., Howitt, B.E., et al. (2015) Inflammatory Myofibroblastic Tumor of the Uterus: Clinical and Pathologic Review of 10 Cases Including a Subset with Aggressive Clinical Course. The American Journal of Surgical Pathology, 39, 157-168. [Google Scholar] [CrossRef] 
[9] Mandato, V.D., Valli, R., Mastrofilippo, V., Bisagni, A., Aguzzoli, L. and La Sala, G.B. (2017) Uterine Inflammatory Myofibroblastic Tumor: More Common than Expected: Case Report and Review. Medicine (Baltimore), 96, e8974. [Google Scholar] [CrossRef] 
[10] Pickett, J.L., Chou, A. andrici, J.A., et al. (2017) Inflamma-tory Myofibroblastic Tumors of the Female Genital Tract Are Under-Recognized: A Low Threshold for ALK Immuno-histochemistry Is Required. The American Journal of Surgical Pathology, 41, 1433-1442. [Google Scholar] [CrossRef] 
[11] Shukla, P.S. and Mittal, K. (2019) Inflammatory Myofibro-blastic Tumor in Female Genital Tract. Archives of Pathology & Laboratory Medicine, 143, 122-129. [Google Scholar] [CrossRef] 
[12] Bennett, J.A., Nardi, V., Rouzbahman, M., Morales-Oyarvide, V., Nielsen, G.P. and Oliva, E. (2017) Inflammatory Myofibroblastic Tumor of the Uterus: A Clinicopathological, Immuno-histochemial and Molecular Analysis of 13 Cases Highlighting Their Broad Morphologic Spectrum. Modern Pathology, 30, 1489-1503. [Google Scholar] [CrossRef] [PubMed]
[13] Zhang, J., Li, Y. and Lou, L. (2018) Uterine Metastases Originat-ing from a Pulmonary Inflammatory Myofibroblastic Tumor. Journal of Cancer Research and Therapeutics, 14, S257-S259. [Google Scholar] [CrossRef] [PubMed]
[14] Coffin, C.M. and Fletcher, J.A. (2013) Inflammatory Myofibroblastic Tumor. In: Fletcher, C.D.M., Bridge, J.A., Hogendoorn, P. and Mertens, F., Eds., WHO Classification of Tumours of Soft Tissue and Bone, 4th Edition, International Agency for Research on Cancer, Lyon, 83-84.
[15] Parra-Herran, C. and Howitt, B.E. (2019) Uterine Mesenchymal Tumors Update on Classification, Staging, and Molecular Features. Surgical Pathology Clinics, 12, 363-396. [Google Scholar] [CrossRef] [PubMed]
[16] Wojcik, J. (2017) Inflammatory Myofibroblastic Tumor with Marked Pseudodecidual Change. United States and Canadian Academy of Pathology, Palm Springs. http://materials.uscap.org/2017specsurg_h4_55518.asp
[17] Gleason, B.C. and Hornick, J.L. (2008) Inflammatory My-ofibroblastic Tumours: Where Are We Now? Journal of Clinical Pathology, 61, 428-437. [Google Scholar] [CrossRef] [PubMed]
[18] Etlinger, P., Kuthi, L. and Kovács, T. (2020) Inflammatory Myofi-broblastic Tumors in the Uterus: Childhood-Case Report and Review of the Literature. Frontiers in Pediatrics, 8, Article No. 36. [Google Scholar] [CrossRef] [PubMed]
[19] Mossé, Y.P. (2016) Anaplastic Lymphoma Kinase as a Cancer Tar-get in Pediatric Malignancies. Clinical Cancer Research, 22, 546-552. [Google Scholar] [CrossRef] 
[20] Mossé, Y.P., Voss, S.D., Lim, S., Rolland, D., Minard, C.G., Fox, E., et al. (2017) Targeting ALK with Crizotinib in Pediatric Anaplastic Large Cell Lymphoma and Inflamma-tory Myofibroblastic Tumor: A Children’s Oncology Group Study. Journal of Clinical Oncology, 28, 3215-3222. [Google Scholar] [CrossRef] 

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