HCV阳性供体肝移植在阴性受体中的研究进展
Research Progress of HCV Positive Donor Liver Transplantation in Negative Recipients
DOI: 10.12677/ACM.2022.127925, PDF,   
作者: 刘东丽, 韩东冬：青海大学附属医院肝胆胰二外科，青海 西宁
关键词: 肝移植；SRV；DAA；FCH；ARC；GVHD；Liver Transplantation； SRV； DAA； FCH； ARC； GVHD
摘要: 肝移植(LT)是治疗终末期肝病和急性肝衰竭的唯一有效方法。目前全球肝移植患者的需求持续并远大于肝脏器官捐赠的供应。由于阿片类药物的广泛使用，感染丙型肝炎病毒(hepatitis C virus, HCV)的捐献者比例不断上升且不断年轻化，在器官短缺的情况下，必须充分利用所有可移植器官。目前，高效且耐受性良好的直接作用抗病毒(DAA)疗法可用于治疗HCV感染，并可在95%以上的病例中消除同种异体移植中的HCV。该文结合国内外最新研究报道对HCV阳性供体肝移植在阴性受体术后安全性和疗效性等方面进行了综述。
Abstract: Liver transplantation (LT) is the only effective treatment for end-stage liver disease and acute liver failure. The global demand for liver transplant patients continues and far outstrips the supply of liver donors. Due to the widespread use of opioids, the proportion of donors infected with hepatitis C virus (hepatitis C virus, HCV) is rising and getting younger, making it imperative to fully utilize all transplantable organs in a shortage of organs. Currently, highly effective and well tolerated direct action antiviral (DAA) therapies are available to treat HCV infection and eliminate HCV in allografts in more than 95% of cases. This article reviews the safety and efficacy of HCV positive donor liver transplantation in patients with negative recipients.
文章引用：刘东丽, 韩东冬. HCV阳性供体肝移植在阴性受体中的研究进展[J]. 临床医学进展, 2022, 12(7): 6421-6427. https://doi.org/10.12677/ACM.2022.127925

参考文献

[1] Stepanova, M., Sayiner, M., de Avila, L., Younoszai, Z., Racila, A. and Younossi, Z.M. (2016) Long-Term Outcomes of Liver Transplantation in Patients with Hepatitis C Infection Are Not Affected by HCV Positivity of a Donor. BMC Gastroenterology, 16, 137. [Google Scholar] [CrossRef] [PubMed]
[2] Goldberg, D.S., Blumberg, E., McCauley, M., Abt, P. and Levine, M. (2016) Improving Organ Utilization to Help Overcome the Tragedies of the Opioid Epidemic. American Journal of Transplantation, 16, 2836-2841. [Google Scholar] [CrossRef] [PubMed]
[3] Gonzalez, S.A. and Trotter, J.F. (2018) The Rise of the Opioid Epidemic and Hepatitis C-Positive Organs: A New Era in Liver Transplantation. Hepatology, 67, 1600-1608. [Google Scholar] [CrossRef] [PubMed]
[4] Kreitman, K.R., Kothadia, J.P., Nair, S.P. and Maliakkal, B.J. (2021) Unexpected Hepatitis B Virus Transmission after Liver Transplant from Nucleic Acid Testing- and Serology-Negative Liver Donors Who Are Hepatitis C Viremic. Hepatology Research, 51, 1242-1246. [Google Scholar] [CrossRef] [PubMed]
[5] Kim, W.R., Lake, J.R., Smith, J.M., et al. (2018) OPTN/SRTR 2016 Annual Data Report: Liver. American Journal of Transplantation, 18, 172-253. [Google Scholar] [CrossRef] [PubMed]
[6] Kwo, P.Y. and Badshah, M.B. (2015) New Hepatitis C Virus Therapies: Drug Classes and Metabolism, Drug Interactions Relevant in the Transplant Settings, Drug Options in Decompen-sated Cirrhosis, and Drug Options in End-Stage Renal Disease. Current Opinion in Organ Transplantation, 20, 235-241. [Google Scholar] [CrossRef] 
[7] Cotter, T.G., Paul, S., Sandikci, B., et al. (2019) Increasing Utilization and Excellent Initial Outcomes Following Liver Transplant of Hepatitis C Virus (HCV)-Viremic Donors into HCV-Negative Recipients: Outcomes Following Liver Transplant of HCV-Viremic Donors. Hepatology, 69, 2381-2395. [Google Scholar] [CrossRef] [PubMed]
[8] Aslam, S., Grossi, P., Schlendorf, K.H., et al. (2020) Utiliza-tion of hepatitis C Virus-Infected Organ Donors in Cardiothoracic Transplantation: An ISHLT Expert Consensus Statement. The Journal of Heart and Lung Transplantation, 39, 418-432. [Google Scholar] [CrossRef] [PubMed]
[9] Durand, C.M., Bowring, M.G., Thomas, A.G., et al. (2018) The Drug Overdose Epidemic and Deceased-Donor Transplantation in the United States: A National Registry Study. Annals of Internal Medicine, 168, 702-711. [Google Scholar] [CrossRef] 
[10] Kwong, A.J., Wall, A., Melcher, M., et al. (2019) Liver Transplantation for Hepatitis C Virus (HCV) Non-Viremic Recipients with HCV Viremic Donors. American Journal of Transplanta-tion, 19, 1380-1387. [Google Scholar] [CrossRef] [PubMed]
[11] Bunchorntavakul, C. and Reddy, K.R. (2016) Treat Chronic Hepatitis C Virus Infection in Decompensated Cirrhosis—Pre- or Post-Liver Transplantation? The Ironic Conundrum in the Era of Effective and Well-Tolerated Therapy. Journal of Viral Hepatitis, 23, 408-418. [Google Scholar] [CrossRef] [PubMed]
[12] Bari, K., Luckett, K., Kaiser, T., et al. (2018) Hepatitis C Transmission from Seropositive, Nonviremic Donors to Non-Hepatitis C Liver Transplant Recipients. Hepatology, 67, 1673-1682. [Google Scholar] [CrossRef] [PubMed]
[13] Luckett, K., Kaiser, T.E., Bari, K., et al. (2019) Use of Hepatitis C Virus Antibody-Positive Donor Livers in Hepatitis C Nonviremic Liver Transplant Recipients. Journal of the American Col-lege of Surgeons, 228, 560-567. [Google Scholar] [CrossRef] [PubMed]
[14] Bohorquez, H., Bugeaud, E., Bzowej, N., et al. (2021) Liver Transplantation Using Hepatitis C Virus-Viremic Donors Into Hepatitis C Virus-Aviremic Recipients as Standard of Care. Liver Transplantation, 27, 548-557. [Google Scholar] [CrossRef] [PubMed]
[15] Kuntzen, C. and Bagha, Z. (2022) The Use of Hepatitis C Virus-Positive Organs in Hepatitis C Virus-Negative Recipients. Clinical Liver Disease, 26, 291-312. [Google Scholar] [CrossRef] [PubMed]
[16] Nair, S.P., Marella, H.K., Maliakkal, B., et al. (2021) Transplanta-tion of Liver from Hepatitis C-Infected Donors to Hepatitis C RNA-Negative Recipients: Histological and Virologic Outcome. Clinical Transplantation, 35, e14281. [Google Scholar] [CrossRef] [PubMed]
[17] Whitcomb, E., Choi, W.T., Jerome, K.R., et al. (2017) Biopsy Specimens from Allograft Liver Contain Histologic Features of Hepatitis C Virus Infection after Virus Eradication. Clinical Gas-troenterology and Hepatology, 15, 1279- 1285. [Google Scholar] [CrossRef] [PubMed]
[18] Anwar, N., Kaiser, T.E., Bari, K., et al. (2020) Use of Hepatitis C Nucleic Acid Test-Positive Liver Allografts in Hepatitis C Virus Sero-negative Recipients. Liver Transplantation, 26, 673-680. [Google Scholar] [CrossRef] [PubMed]
[19] Barsoum, R.S., William, E.A. and Khalil, S.S. (2017) Hepatitis C and Kidney Disease: A Narrative Review. Journal of Advanced Re-search, 8, 113-130. [Google Scholar] [CrossRef] [PubMed]
[20] Narang, T.K., Ahrens, W. and Russo, M.W. (2010) Post-Liver Transplant Cholestatic Hepatitis C: A Systematic Review of Clinical and Pathological Findings and Application of Consensus Criteria. Liver Transplantation, 16, 1228- 1235. [Google Scholar] [CrossRef] [PubMed]
[21] Verna, E.C., Abdelmessih, R., Salomao, M.A., Lefkowitch, J., Moreira, R.K. and Brown, R.S. (2013) Cholestatic Hepatitis C Following Liver Transplantation: An Outcome-Based Histologi-cal Definition, Clinical Predictors, and Prognosis. Liver Transplantation, 19, 78-88. [Google Scholar] [CrossRef] [PubMed]
[22] Satapathy, S.K., Sclair, S., Fiel, M.I., Del Rio Martin, J. and Schiano, T. (2011) Clinical Characterization of Patients Developing Histologically-Proven Fibrosing Cholestatic Hepatitis C Post-Liver Transplantation. Hepatology Research, 41, 328-339. [Google Scholar] [CrossRef] 
[23] Ting, P.S., Hamilton, J.P., Gurakar, A., et al. (2019) Hepatitis C-Positive Donor Liver Transplantation for Hepatitis C Seronegative Recipients. Transplant Infectious Dis-ease, 21, e13194. [Google Scholar] [CrossRef] [PubMed]
[24] Terrault, N.A., Burton, J., Ghobrial, M., et al. (2021) Prospective Multicenter Study of Early Antiviral Therapy in Liver and Kidney Transplant Recipients of HCV-Viremic Donors. Hepatology, 73, 2110-2123. [Google Scholar] [CrossRef] [PubMed]
[25] Murali, A.R., Chandra, S., Stewart, Z., et al. (2016) Graft Versus Host Disease after Liver Transplantation in Adults: A Case Series, Review of Literature, and an Approach to Management. Transplantation, 100, 2661-2670. [Google Scholar] [CrossRef] 
[26] Cheung, M., Walker, A.J., Hudson, B.E., et al. (2016) Out-comes after Successful Direct-Acting Antiviral Therapy for Patients with Chronic Hepatitis C and Decompensated Cirrhosis. Journal of Hepatology, 65, 741-747. [Google Scholar] [CrossRef] [PubMed]
[27] Belli, L.S., Berenguer, M., Cortesi, P.A., et al. (2016) Delisting of Liver Transplant Candidates with Chronic Hepatitis C after Viral Eradication: A European Study. Journal of Hepa-tology, 65, 524-531. [Google Scholar] [CrossRef] [PubMed]
[28] Emamaullee, J.A., Bral, M., Meeberg, G., et al. (2019) HCV Eradication with Direct-Acting Antivirals Does Not Impact HCC Progression on the Waiting List or HCC Recurrence after Liver Transplantation. Canadian Journal of Gastroenterology and Hepatology, 2019, Article ID: 2509059. [Google Scholar] [CrossRef] [PubMed]
[29] Saberi, B., Hamilton, J.P., Durand, C.M., et al. (2018) Utilization of Hepatitis C Virus RNA-Positive Donor Liver for Transplant to Hepatitis C Virus RNA-Negative Recipient. Liver Transplantation, 24, 140-143. [Google Scholar] [CrossRef] [PubMed]
[30] Selzner, N. and Berenguer, M. (2018) Should Organs from Hepatitis C-Positive Donors Be Used in Hepatitis C-Negative Recipients for Liver Transplantation. Liver Transplantation, 24, 831-840. [Google Scholar] [CrossRef] [PubMed]
[31] Hori, T., Onishi, Y., Kamei, H., et al. (2016) Fibrosing Cholestatic Hepatitis C in Post-Transplant Adult Recipients of Liver Transplantation. Annals of Gastroenterology, 29, 454-459. [Google Scholar] [CrossRef] [PubMed]
[32] Bethea, E., Arvind, A., Gustafson, J., et al. (2020) Immediate Ad-ministration of Antiviral Therapy after Transplantation of Hepatitis C-Infected Livers into Uninfected Recipients: Implications for Therapeutic Planning. American Journal of Transplantation, 20, 1619-1628. [Google Scholar] [CrossRef] [PubMed]
[33] Levitsky, J., Verna, E.C., et al. (2016) Perioperative Ledipas-vir-Sofosbuvir for HCV in Liver-Transplant Recipients. The New England Journal of Medicine, 375, 2106-2108. [Google Scholar] [CrossRef] 
[34] Kapila, N., Menon, K., Al-Khalloufi, K., et al. (2020) Hepatitis C Virus NAT-Positive Solid Organ Allografts Transplanted Into Hepatitis C Virus-Negative Recipients: A Real-World Experience. Hepatology, 72, 32-41. [Google Scholar] [CrossRef] [PubMed]
[35] 朱倩, 张明媛, 牛俊奇. 直接抗病毒药物治疗HCV相关肝细胞癌肝移植受者的研究进展[J]. 临床肝胆病杂志, 2021, 37(10): 2444-2447.
[36] Cotter, T.G., Aronsohn, A., Reddy, K.G. and Charlton, M. (2021) Liver Transplantation of HCV-Viremic Donors into HCV-Negative Recipients in the United States: Increasing Frequency with Profound Geographic Variation. Transplantation, 105, 1285-1290. [Google Scholar] [CrossRef] 
[37] Chhatwal, J., Samur, S., Bethea, E.D., et al. (2018) Trans-planting Hepatitis C Virus-Positive Livers into Hepatitis C Virus-Negative Patients with Preemptive Antiviral Treat-ment: A Modeling Study. Hepatology, 67, 2085-2095. [Google Scholar] [CrossRef] [PubMed]

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