中国中老年非住院患者尿酸水平与膝骨关节炎的相关性

Relationship between Uric Acid Level and Knee Osteoarthritis in Middle-Aged and Elderly Chinese Patients

摘要: 目的：血尿酸水平与膝骨关节炎之间的关联性尚存在争议，我们的研究目的是在确定血尿酸水平与膝骨关节炎之间的相关性。方法：基于中国健康与退休纵向研究(China Health and Retirement Longitudinal Study, CHARLS)进行的全国中老年基线数据调查，共纳入5176名中老年男性非住院患者(年龄 ≥ 45岁)。采用logistic回归模型、受试者工作特征(ROC)曲线对血尿酸水平与膝骨关节炎患病率进行相关性研究。结果：血尿酸与KOA发病具有显著相关性(P = 0.001, OR = 1.386, 95% CI 1.319~1.455)。结论：在中国中老年男性非住院患者人群中，血尿酸水平与膝骨关节炎具有相关性，血尿酸水平能预测膝骨关节炎发病率。

Abstract: Objective: The association between blood uric acid levels and knee osteoarthritis is controversial, the purpose of our study is to determine the association between blood uric acid levels and knee osteoarthritis. Methods: A total of 5176 middle-aged and elderly male non-hospitalized patients (aged ≥ 45 years) were included in the National Baseline Data Survey of middle-aged and elderly based on the China Health and Retirement Longitudinal Study (CHARLS). Logistic regression model and receiver operating characteristic (ROC) curve were used to study the correlation between blood uric acid level and the prevalence of knee osteoarthritis. Results: There was a significant correlation between serum uric acid and KOA (P = 0.001, OR = 1.386, 95% CI 1.319~1.455). Conclusion: The serum uric acid level is associated with knee osteoarthritis in middle-aged and elderly male non-hospitalized patients in China, and it can predict the incidence of knee osteoarthritis.