双相抑郁认知功能损害磁共振成像研究进展
Research Progress in Magnetic Resonance Imaging of Cognitive Impairment in Bipolar Depression
DOI: 10.12677/IJPN.2023.122002, PDF,   
作者: 王孟璞：温州医科大学精神医学学院，浙江 温州；许海云*：温州医科大学精神医学学院，浙江 温州；温州医科大学附属康宁医院，浙江省精神心理疾病临床医学研究中心，浙江 温州
关键词: 双相抑郁；多模态磁共振；默认模式网络；皮层厚度；各向异性分数；Bipolar Depression； Multimode Magnetic Resonance； Default Mode Network； Cortical Thickness； An-isotropic Fraction
摘要: 双相抑郁障碍(BDD)是一类重型精神障碍。患者以情绪不稳定为临床特点，主要表现为情绪低落与情感高涨交替出现或同时出现。此外，部分患者也同时存在认知功能损害，而且药物治疗对恢复认知功能见效甚微。物理治疗，包括重复经颅磁刺激，在短时间内可以部分改善双相障碍患者的认知功能，但难以长期维持。存在这些挑战是因为我们尚未充分了解该病的发病机制。磁共振成像是一种无创性的脑影像学技术，已经被广泛地应用于包括双相障碍在内的精神疾病的临床和实验研究。本文较系统地复习了近年来利用磁共振成像术研究双相抑郁障碍的临床研究，并扼要概括了研究进展。
Abstract: Bipolar Depressive Disorder (BDD) is a severe mental disorder. Patients with emotional instability as clinical characteristics, the main manifestations of low mood and high mood occur alternately or simultaneously. In addition, some patients also have cognitive impairment, and drug therapy has little effect on restoring cognitive function. Physical therapy, including repetitive trans-cranial magnetic stimulation, can partially improve cognitive function in patients with BDD in the short term, but is difficult to maintain in the long term. These challenges exist because we do not yet fully understand the pathogenesis of the disease. Magnetic Resonance Imaging (MRI) is a noninvasive brain imaging technique that has been widely used in clinical and experimental studies of mental disorders, including BDD. This review systematically reviews the recent clinical studies with BDD patients using various kinds of MRI and briefly summarizes the research progress.
文章引用：王孟璞, 许海云. 双相抑郁认知功能损害磁共振成像研究进展[J]. 国际神经精神科学杂志, 2023, 12(2): 17-25. https://doi.org/10.12677/IJPN.2023.122002

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