中医药防治肺结节/早期肺癌研究进展

Research Progress on Prevention and Treatment of Lung Nodules/Early Lung Cancer by Traditional Chinese Medicine

摘要: 肺癌是全球和中国癌症相关死亡的首要原因，是全球严重的公共健康问题，肺癌发病率高，预后差，因此早期诊断及预防对于改善肺癌患者预后很重要。研究发现，微生物感染可导致癌症，肠道菌群对恶性肿瘤的发生发展有一定的影响。肺结节是肺癌的常见表现形式之一，肠道菌群或可作为肺结节/早期肺癌诊断的潜在标志物，靶向调控特定肠道微生物或肠道菌群组成或可可影响肺结节/早期肺癌的进程。中医药在治疗肺结节方面具有多作用靶点、多效应响应的特点，另外，相比于手术及放化疗，中医药还具有毒副作用小，保护自身免疫，增强肺功能，提高患者机体抵抗肿瘤侵袭的能力。中医药或可靶向肠道菌群对肺结节/早期肺癌进行干预，达到“未病先防，既病防变”的目的。

Abstract: Lung cancer is the leading cause of cancer-related death in the world and China, and it is a serious public health problem in the world. The incidence of lung cancer is high and the prognosis is poor. Therefore, early diagnosis and prevention are important to improve the prognosis of patients with lung cancer. Studies have found that microbial infection can lead to cancer, and intestinal flora has a certain impact on the occurrence and development of malignant tumors. Pulmonary nodules are one of the common manifestations of lung cancer, and intestinal flora may be used as a potential marker for the diagnosis of pulmonary nodules/early lung cancer, targeting specific intestinal mi-croorganisms or intestinal flora composition, or cocoa affecting the progression of pulmonary nod-ules/early lung cancer. Traditional Chinese medicine has the characteristics of multi-action targets and multi-effect response in the treatment of pulmonary nodules. In addition, compared with sur-gery and chemoradiotherapy, traditional Chinese medicine also has less toxic and side effects, pro-tects autoimmunity, enhances lung function, and improves patients’ ability to resist tumor invasion. Traditional Chinese medicine may target intestinal flora to intervene in lung nodules/early lung cancer, so as to achieve the purpose of “prevention before disease and prevention of disease”.