中性粒细胞在UC中炎症机制的研究进展
Advances in Inflammatory Mechanisms of Neutrophils in UC
摘要: 溃疡性结肠炎(Ulcerative Colitis, UC)是一种自身免疫性、弥漫性、非消退性肠道粘膜炎症性肠病。目前中性粒细胞(Neutrophils, NEU)浸润在UC发生过程中的作用被越来越多的学者所研究,其可释放活性氧、嗜中性粒细胞陷阱、中性粒细胞弹性蛋白酶及相关炎性因子从而导致组织损伤。同时,中性粒细胞及其相关炎症因子在疾病诊断、评估活动性、预测临床预后等方面有着重要参考价值。本文就NEU在UC发生、发展过程中的作用及机制作一综述。
Abstract: Ulcerative colitis (UC) is an autoimmune, diffuse, non-recessive inflammatory bowel disease of the intestinal mucosa. The role of neutrophils (NEU) infiltration in the development of UC, which can release reactive oxygen species (ROS), neutrophil traps, neutrophil elastase, and related inflammatory factors leading to tissue damage, has been increasingly studied. Meanwhile, neutrophils and their associated inflammatory factors have important reference value in disease diagnosis, assessment of activity, and prediction of clinical prognosis. This article provides a review of the role and mechanism of NEU in the process of UC occurrence and development.
文章引用:陈瑶, 黄维莉. 中性粒细胞在UC中炎症机制的研究进展[J]. 临床医学进展, 2024, 14(6): 1485-1489. https://doi.org/10.12677/acm.2024.1461939

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