标题:
副溶血弧菌噬菌体基因组研究进展Recent Advance in Genomes of Vibrio parahaemolyticus Bacteriophages
作者:
赵江涛
关键字:
副溶血弧菌, 噬菌体治疗, 基因组Vibrio parahaemolyticus, Bacteriophage Therapy, Genome
期刊名称:
《QianRen Biology》, Vol.2 No.3, 2015-08-13
摘要:
副溶血性弧菌是一种嗜盐性弧菌，常分布于沿岸海水、海河交界处及海产品中。它是我国沿海地区最常见的食物中毒病原菌。食物(尤其是海产品)未作适当处理可能污染大量的副溶血弧菌，导致食物中毒。副溶血弧菌可以导致胃肠炎、伤口感染和败血病。更为重要的是，多重耐药副溶血弧菌的出现极大的威胁着人类的健康并且给抗生素治疗提出了严峻的挑战。而噬菌体治疗是控制细菌感染和污染的抗生素替代方案。对噬菌体基因组结构和基因功能的认知是实现噬菌体治疗的必需步骤。目前，国外已经有多篇关于副溶血弧菌噬菌体基因组的报道，本文立足于近几年的最新进展，着重综述了副溶血弧菌噬菌体的基因组特点。
Vibrio parahaemolyticus (VP) is a halophilic vibrio strain; it mainly exists in the coast sea water, the junction of river and sea, and the seafood. It is the most common food poisoning pathogenic bacteria in the coastal areas of China. Food (especially seafood) that not properly treated may contain large number of VP, resulting in food poisoning. VP can cause gastroenteritis, wound in-fection and septicemia. Most importantly, the emergence of multiple drug resistant VP has greatly threatened human health and caused a severe challenge to the treatment of antibiotics. Bacteriophage therapy is considered as an alternative way of controlling bacterial infections and contaminations. Recognition and analysis of genome structure and genes function are the required steps before bacteriophages can be approved as therapeutic agents. Up to date, there are many reports of VP phages’ genomes; this paper summarizes the latest progress in recent years, focusing on a review on the genomic features of Vibrio parahaemolyticus bacteriophage.