标题:
5-羟色胺在孤独症谱系障碍中的研究进展Research Progress of Serotonin in Autism Spectrum Disorders
作者:
王丽丽, 杜琳, 单玲, 冯俊燕, 贾飞勇
关键字:
孤独症谱系障碍, 5-HT, 5-HTTAutism Spectrum Disorder, 5-HT, 5-HTT
期刊名称:
《International Journal of Psychiatry and Neurology》, Vol.4 No.3, 2015-08-27
摘要:
孤独症谱系障碍(ASD)是一组以不同程度的社会交流、交往障碍和限制性、重复性行为、兴趣及活动异常为主要特征的发育行为障碍性疾病。ASD的发病率逐渐增加，但其病因不明。5-羟色胺(5-HT)是一种在人体中广泛存在的单胺类神经递质，对神经精神活动等具有一定的调节作用。研究发现，ASD患者的5-HT水平在外周血中升高，脑内降低，这种反常现象在ASD患者中较为常见。且5-HT转运体(5-HTT)基因异于常人。因此，5-HT系统的异常可能是影响ASD的一项危险因素。
Autism spectrum disorder (ASD) is a group of developmental behavioral disorders which have the main features like different levels of social interaction and communication barriers, restrictive and repetitive behaviors and abnormal interests and activities. The onset of ASD shows a trend of increase year by year, but its etiology is unknown. Serotonin is a monoamine neurotransmitter which is widely present in the human body and has a regulatory role in other neuropsychiatric events. The study found that the 5-HT of patients with ASD level increased in peripheral blood and decreased in the brain. This anomaly was common in ASD patients. 5-HT transporter gene was different from ordinary people. Therefore, the abnormality of 5-HT system may be a risk factor for ASD.