标题:
阿司匹林与氯吡格雷抗血小板凝聚不良反应临床分析To Analyze the Adverse Drug Reaction of Asprin and Clopidogrel during the Treatment for Platelet Aggregation
作者:
黄之训, 张惠芳, 沈筱云, 周陶然, 钱石静
关键字:
阿司匹林, 氯吡格雷, 不良反应, 分析Aspirin, Clopidogrel, Adverse Drug Reaction, Analysis
期刊名称:
《Medical Diagnosis》, Vol.5 No.3, 2015-09-07
摘要:
目的：分析阿司匹林、氯吡格雷在抗血小板聚集治疗中的ADR及影响ADR结果的危险因素，为临床用药提供参考。方法：以2009-2012年上海ADR中心数据库阿司匹林和氯吡格雷病例为基数，通过年龄或单抗和双抗治疗随机分组进行回顾性分析，以报告类型、严重程度、原患疾病、用药原因、ADR致器官损害、ADR起始发病日、ADR结果作为观察指标，使用SPSS软件进行分析。结果：单抗和双抗两组基线特征比较差异无统计学意义(p> 0.05)。两组观察指标相关性检查及单因素独立危险因素比较，严重程度、出血、ADR结果和ADR最初阶段发病p
Objective:
To analyze the adverse drug reaction and their risk factors of Aspirin and Clopidogrel
during the treatment for platelet aggregation, providing reference for clinical
medication. Methods: Based on 2009-2012 database of Shanghai ADRs center, ADR
cases about Aspirin and Clopidogrel were analyzed retrospectively through age
groups or randomized by combination and independence for retrospective
analysis. Also the types of reports, severity of diseases, the original
disease, the reason of medication, organ damage by ADR, as well as the initial
period and results of ADRs were applied as the observation indexes and were
analyzed by using the SPSS software. Results: In the groups of combination and
independence, their p value of baseline characteristics was above 0.05 (p > 0.05), which indicated no
statistical significance. In contrast, p values of observation index
correlation test, report types, severity, bleeding part, ADR results and the
initial period of ADR were below the level of 0.05 (p p