标题:
高通量DNA合成测序化学研究进展Advance in Sequence Chemistry of High-Throughput DNA Sequencing by Synthesis
作者:
陈婧, 肖鹏峰
关键字:
生物化学, 高通量DNA测序, 合成测序, 测序化学Biochemistry; High-Throughput DNA Sequencing; DNA Sequencing-by-Synthesis; Sequencing Chemistry
期刊名称:
《Bioprocess》, Vol.2 No.1, 2012-03-23
摘要:
高通量DNA测序是近年来发展起来的革命性技术，大大推动了快速、廉价获取基因组信息的能力，进而对生命科学产生深刻的影响。测序化学是高通量DNA测序的重要内容，且发展十分迅速；一些构思巧妙的新颖测序化学方法被相继报道，本文综述了高通量DNA测序化学的最新研究进展。
High-throughput DNA sequencing, a revolutionized technology, greatly accelerated mining data from ge- nomes rapidly and cost-efficiently, thus have a profound impact on life sciences. Sequencing chemistry is a pivotal part of high-throughput DNA sequencing, and has been developed dramatically in recently years; a number of ingenious methods of novel sequencing chemistry by synthesis have been reported. In this paper, the development of high- throughput DNA sequencing chemistry by synthesis is reviewed.