Godinho, S.A., Picone, R., Burute, M., Dagher, R., Su, Y., Leung, C.T., Polyak, K., Brugge, J.S., Théry, M. and Pellman, D. (2014) Oncogene-Like Induction of Cellular Invasion from Centrosome Amplification. Nature, 7503, 167-171.
http://dx.doi.org/10.1038/nature13277
被以下文章引用:
-
标题:
基于三维培养下的肿瘤细胞恶性研究Study of Cancer Cell Malignancy Based on Three-Dimensional Cell Culture Technology
作者:
郭振超, 张天柱
关键字:
三维细胞培养, 肿瘤微环境, 肿瘤细胞恶性, 耐药性评价Three-Dimensional Cell Culture, Tumor Microenvironment, Malignancy of Cancer Cells, Drug Resistance Evaluation
期刊名称:
《Open Journal of Natural Science》, Vol.4 No.2, 2016-05-09
摘要:
为了认识肿瘤侵袭转移的规律，干预治疗改善肿瘤的恶性，肿瘤细胞的科学研究已竞相采用三维培养技术。三维细胞培养与传统的二维培养方法相比，更能模拟接近机体内细胞生存的真实环境。作为一种更为方便、有用的技术，目前在三维培养条件下模拟体内肿瘤细胞微环境研究肿瘤细胞的恶性分化、侵袭转移、化学靶向治疗和耐药性评价已经成为生物医药领域的研究热点。
In order to understand the law of the invasion and metastasis of cancer cells and decrease the malignancy of tumor, three-dimensional culture techniques have been wildly used in tumor cells scientific research. The technology of three-dimensional cell culture is a more convenient and useful technology than traditional two-dimensional culture; it can simulate closer to the cell sur-vival in the real environment. Through three-dimensional culture by simulating tumor microen-vironment, the study of malignant tumor cell differentiation, invasion and metastasis, chemical targeted therapy and drug resistance evaluation in vitro has become a hot research topic in the field of biomedicine today.