代谢组学在结直肠癌早期诊断中的应用进展Application and Progress of Metabolic Proteomics in Early Diagnosis of Colorectal Cancer
刘明浩, 李萍, 胡文炜, 李雪, 王瑞玲, 王瑞玲
结直肠癌, 代谢组学, 筛查, 诊断Colorectal Cancer, Metabonomics, Screening, Diagnosis
《Advances in Clinical Medicine》, Vol.6 No.2, 2016-06-13
Although the treatment methods of colorectal cancer have experienced constant innovations and development, the prognosis remains poor, especially among patients with advanced colorectal can-cer. Early diagnosis and treatment may significantly improve the five-year survival rate of these pa-tients. Colorectal cancer not only shortens mean life span, but also percolates the social economy. Traditional screening methods of colorectal cancer mainly include fecal occult blood detection and colonoscopy. Fecal occult blood detection focuses on the sensitivity of colerectal cancer but has low specificity, while colonoscopy is invasive, expensive and subject to some risk. These two methods fail to meet the requirements for early diagnosis of colorectal cancer. Therefore, there is an urgent need for a screening method for early detection and early diagnosis of colorectal cancer in order to prolong the survival time of patients with colorectal cancer and improve the prognosis. Following genomics, transcriptomics and proteomics, metabolomics comes into being as a new “omics” that carries out dynamic, quantitative and qualitative analyses of thousands of intermediate products and end products entering into a sequence of biochemical reactions, thus reflecting various physiological, pathological and growth statuses. Recent studies have found that metabolomics had a wide range of uses in cancer researches, including early tumor diagnosis, staging, therapeutic evaluation, prognosis prediction and so on; researchers on colorectal cancer also included. This provides new ways for establishing effective, stable and reliable methods of early diagnosis of colorectal cancer. This review mainly presents an introduction to the concept and research techniques of metabolomics, as well as advances in its applications in early diagnosis of colorectal cancer.