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S. P. Chavan, D. A. Khobragade, S. K. Kamat, et al. An efficient and green protocol for the preparation of cycloalkanols: A practical synthesis of venlafaxine. Tetrahedron Letters, 2004, 45: 7291-7295.

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• 标题: 盐酸文拉法辛的合成Synthesis of Venlafaxine Hydrochloride

  作者: 朱园园, 李婷婷, 古双喜

  关键字: 盐酸文拉法辛, 合成, 抗抑郁药, 茴香醇Venlafaxine Hydrochloride; Synthesis; Antidepressant; Anisic Alcohol

  期刊名称: 《Studies in Synthetic Chemistry》, Vol.1 No.1, 2013-10-08

  摘要: 以廉价易得的茴香醇为原料，经7步反应以56.7%的总收率合成得到盐酸文拉法辛。该路线简捷高效，反应条件温和，后处理操作简单，适合工业化生产。 Venlafaxine hydrochloride was synthesized via 7-step reactions in the total yield of 56.7% from anisic alcohol. The synthetic route is concise and efficient, and suitable for industrialization due to its mild reaction conditions and simple post-treatment.