标题:
夹心层结构的纳米银复合粒子的缓释抑菌性Prolonged Antimicrobial Activity of Unique Sandwich-Structured Silver Nanocomposites
作者:
宋笑, 刘涛, 董丽华, 郭章伟, 董耀华, 申媛媛
关键字:
银, 纳米复合粒子, 多巴胺, 抑菌性能, 结构Silver, Nanocomposite, Dopamine, Antibacterial Activity, Structure
期刊名称:
《Hans Journal of Nanotechnology》, Vol.4 No.2, 2014-05-05
摘要:
本文为了证明纳米颗粒的结构对抑菌性能具有很大的影响效果，制备出了三种不同结构的纳米银复合粒子。它们分别是：(1) 通过还原银离子制备纳米银颗粒，并使其包覆在二氧化硅–聚多巴胺球形颗粒表面形成复合粒子(SiO2/PD/Ag)。(2) 将纳米银颗粒负载在球形介孔二氧化硅内，形成核–壳结构的复合粒子(Ag@MSN)。(3) 纳米银颗粒既粘附在二氧化硅球形表面又封装在二氧化硅内层而形成的具有独特夹心层结构的复合粒子(Ag@MSN/PD-Ag)。采用革兰氏阴性菌–需钠弧菌的生长曲线来测试三种粒子的抑菌性能。实验结果表明，在最初的三天里，SiO2/PD/Ag较Ag@MSN对需钠弧菌抑制效果更好，但是接下来的七天，Ag@MSN对需钠弧菌更为敏感，而Ag@MSN/PD-Ag在整个十天的抑菌测试中一直都是对需钠弧菌最为敏感。
In this study, silver nanocomposites with three different structures were prepared to confirm that structure has a significant influence on the antibacterial properties. Ag nanoparticles were prepared by the following three methods: 1) by deposition of Ag on the surface of silica-polydopamine spheres by reducing Ag cations (SiO2/PD/Ag); 2) by encapsulation of Ag NPs in mesoporous SiO2 with a core- shell structure (Ag@MSN); and 3) Ag nanocrystals were both decorated on the surface of SiO2 and incorporated into its mesoporous structure (Ag@MSN/PD-Ag). The antibacterial activities of these particles were evaluated through bacterial growth curves. The results demonstrated that in the first three days, the effect of SiO2/PD/Ag was more intense on V. natriegens compared with Ag@MSN; however, the next seven days revealed the opposite result. Therefore, Ag@MSN/PD-Ag exhibited the most effective antimicrobial treatments for ten days.