Mani, T., Wang, F., et al. (2013) Small-molecule inhibition of the uPAR, uPA interaction: Synthesis, biochemical, cellular, in vivo pharmacokinetics and efficacy studies in breast cancer metastasis. Bioorganic & Medicinal Chemistry, Bioorganic & Medicinal Chemistry, 21, 2145-2155.
恶性卵巢癌抗肿瘤间质治疗策略研究进展The Progress of Antitumor Interstitial Treatment Strategy of Malignant Ovarian Cancer
郭振超, 张天柱, 顾宁
卵巢癌, 化疗耐药, 肿瘤间质, 生存率Ovarian Cancer; Chemotherapy Resistance; Tumor Interstitium; Survival Rate
《Asian Case Reports in Obstetrics and Gynecology》, Vol.1 No.4, 2014-05-13
More than 80% of the patients with ovarian cancer chemotherapy relapse due to drug resistance, which makes the highest ovarian cancer mortality rates among the gynecologic malignancies. Compared with the highly heterogeneous tumor cell differentiation, tumor stroma cells have genetic stability, and it is unlikely to produce acquired mutations and lead to drug resistance. In view of the treatment strategies for tumor interstitium, ovarian cancer is reviewed in this paper. At the same time, we pointed out the direction for reducing toxicity, preventing the cancer recurrence and metastasis, improving the survival rate in the treatment of gynecologic malignancies.