Rischer, H., Oresic, M., Seppanen-Laakso, T., Katajamaa, M., Lammertyn, F., Ardiles-Diaz, W., Van Montagu, M.C., Inze, D., Oksman-Caldentey, K.M. and Goossens, A. (2006) Gene-to-metabolite networks for terpenoid indole alkaloid biosynthesis in Catharanthus roseus cells. Proceedings of the National Academy of Sciences of the United States of America, 103, 5614-5619.
被以下文章引用:
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标题:
长春花生物碱代谢生物学研究进展The Catharanthus Terpenoid Indole
Alkaloids: Metabolic Biology Review
作者:
成海宁, 唐中华
关键字:
长春花, 生物碱, 代谢生物学, 调控因子, 生物合成Catharanthus roseus, Alkaloid, Metabolic Biology, Regulatory Factor, Biosynthesis
期刊名称:
《Botanical Research》, Vol.3 No.3, 2014-05-23
摘要:
随着长春碱和长春新碱日益成为近年来抗癌药物研发的重要对象，长春花生物碱受到了广泛的关注，与其相关的研究也随之得到了较快的发展。生物碱代谢生物学是在各门学科的基础上应运而生的一门跨领域的新兴交叉学科，它研究的是生物碱在代谢途径中的代谢生物学过程及其功能。本文从长春花生物碱的代谢途径、代谢控制因子，以及长春花生物碱的合成和贮存部位等方面，对长春花生物碱代谢生物学作以简要综述，对长春花生物碱的生物学功能的研究提出了展望。
The alkaloids in Catharanthus roseus are noticed extensively as vinblastine and vincristine have been the important anticancer drugs recently, and the concerned studies developed rapidly. On the basis of many disciplines, metabolic biology of alkaloid is a new interdiscipline which contains many fields, and what it studied is the biosynthetic process of the alkaloids in the biosynthetic pathway. This paper attempts to give a brief review on the metabolic biology of the alkaloids in Catharanthus roseus, involving the biosynthetic pathway, regulatory factors, and biosynthesis and storage position of the alkaloids in C. roseus, and the perspective of researches on biological function also has been given.