标题:
PGRMC1蛋白功能及其在肿瘤发生发展中的作用The Function of PRGMC1 and Its Role in Tumorgenesis and Tumor Development
作者:
马雯, 夏祥颖, 梁淑芳
关键字:
PGRMC1蛋白, 肿瘤, 标志物PGRMC1; Cancer; Biomarker
期刊名称:
《Hans Journal of Biomedicine》, Vol.3 No.2, 2013-04-30
摘要:
孕酮受体膜组分1蛋白(PGRMC1)在乳腺癌，甲状腺癌，结肠癌，卵巢癌和肺癌等多种肿瘤组织和肿瘤细胞系中高表达。PGRMC1蛋白在肿瘤的生长和促进肿瘤细胞的存活中发挥作用，它还可以抵制肿瘤细胞凋亡，促进锚着独立生长，侵袭以及肿瘤生长和转移。PGRMC1蛋白还调节胆固醇合成，其信号转导对于癌症的发展是非常重要的，进一步深入研究PGRMC1蛋白与肿瘤发生的关系有助于寻找新的肿瘤标志物，将为肿瘤的早期诊断与预后以及有效药物靶点的发现提供理论和实验依据。Progesterone receptor membrane component 1 (PGRMC1) is overexpressed in breast, colon, ovarian, lung and thyroid tumor tissues, as well as in cancer cell lines. PGRMC1 is associated with tumor growth and development, and it also can resist apoptosis of tumor cells, promote tumor growth independently and benefit to invasion and metas-tasis of tumor. PGRMC1 regulates cholesterol synthesis and signal transduction. Further studies on the relationship be-tween PGRMC1 and tumorigenesis will help to find new cancer biomarkers, which will provide theoretical and experi-mental evidences for early diagnosis and prognosis, as well as effective drug target for cancer.