标题:
钯催化烯丙基碳酸肟脱羧合成烯丙基肟Palladium-Catalyzed Allyl Oxime from Allyloxycarbonyl Oxime
作者:
蔡波, 李文广, 皮少锋, 孙汉州
关键字:
钯, 脱羧, 烯丙基肟Palladium, Decarboxylation, Allyl Oxime
期刊名称:
《Journal of Organic Chemistry Research》, Vol.3 No.1, 2015-03-31
摘要:
肟类化合物是一类重要的含氮化合物，广泛存在于天然产物、药物和活性物质的一种单元结构，是一种重要的有机合成中间体。研究了在钯催化条件下烯丙基碳酸肟脱羧反应，发展了一种反应条件温和，原料便宜易得，对环境友好的合成烯丙基肟方法，在常温下，以Pd(PPh3)4为催化剂，DCM为溶剂的反应体系中，反应8分钟就可以得到较高收率的烯丙基肟。并对该反应可能的机理进行了探讨。
Oximes, which are important classes of nitrogen compounds, are ubiquitous in natural products, drugs as well as materials, and are important intermediates in organic synthesis. We have devel-oped a mild and convenient protocol for the synthesis of allyl oximes. In the presence of Pd(PPh3)4 and DCM, allyloxycarbonyl oximes successfully underwent decaboxylate reaction at room tem-perature to afford the corresponding allyl oximes in moderate good yields in eight minutes. And the possible mechanism of the reaction was discussed.