AAC  >> Vol. 4 No. 1 (February 2014)

    Research Progress on the Determination Methods for the Phthalic Acid Ester Compounds in Food

  • 全文下载: PDF(350KB) HTML    PP.1-6   DOI: 10.12677/AAC.2014.41001  
  • 下载量: 2,047  浏览量: 10,626  


王 萍,王晓燕,周阿蒙,王哲君,沈昊宇:浙江大学宁波理工学院生物与化学工程学院,宁波

食品邻苯二甲酸酯类化合物前处理技术检测方法研究进展Food; Phthalic Acid Esters (PAEs); Pre-Preparation Techniques; Analytic Methods; Research Progress



Phthalic acid esters (PAEs), widely used as plasticizers in toys, food packaging materials, medical bags, hose products, and hundreds of polymer products, are inevitably retained in and shifted to various packaging materials, even into foods. Their chemical toxicities are increasingly attracting public attention in recent years. To develop rapid and accurate analytic methods for the determination of phthalic acid esters (PAEs) in various matrices has become one of the hot topics nowadays. This paper summarized the properties and harmfulness of PAEs, the recent progress on the pre-preparation techniques and the analytic methods for PAEs in food. Some existing problems and challenges in cur- rent analytic methods, as well as the research trends, have been discussed.

王萍, 王晓燕, 周阿蒙, 王哲君, 沈昊宇. 食品中邻苯二甲酸酯类化合物的检测方法研究进展[J]. 分析化学进展, 2014, 4(1): 1-6. http://dx.doi.org/10.12677/AAC.2014.41001


[1] Cao, X.L. (2010) Phthalate esters in foods: Sources, occurrence, and analytical methods. Comprehensive Reviews in Food Science and Food Safety, 9, 21-43.
[2] 宋首屹 (2013) 塑化剂疑云. 中国包装报道, 1, 56-59.
[3] Castillo, M. and Barcelo, D. (1997) Analysis of industrial effluents to determine endocrine-disrupting chemicals. Trends in Analytical Chemistry, 16, 574-583.
[4] US Environmental Protection Agency (2009) Phthalates action plan. http://www.epa.gov/oppt/existingchemicals/pubs/actionplans/phthalates_ap_2009_1230_final.pdf
[5] Fukuwatari, T., Suzuki, Y., Sugimoto, E. and Shibata, K. (2002) Elucidation of the toxic mechanism of the plasticizers, phthalic acid esters, putative endocrine disrupters: Effects of dietary di(2ethylhexyl) phthalate on the metabolism of tryptophan to niacin in rats. Bioscience, Biotechnology, and Biochemistry, 66, 705710.
[6] Lorz, P.M., Towae, F.K., Enke, W., et al. (2007) Phthalic acid and derivatives. In Ullmann’s Encyclopedia of Industrial Chemistry, Wiley-VCH, Weinheim.
[7] 雄星, 韩中豪, 刘必寅, 等 (2007) 邻苯二甲酸酯的毒性及其在环境中的分布环境. 科学与管理, 1, 37-40.
[8] 张炽坚, 张明明, 孙远明, 等 (2012) 邻苯二甲酸二丁酯和二(2-乙基己基)酯对大鼠尿液中超氧化物歧化酶活力和丙二醛含量的影响. 南方医科大学学报, 2, 160-164.
[9] Colacino, J.A., Harris, T.R. and Scheter, A. (2010) Dietary intake is associated with phthalate body burden in a nationally representative sample. Environmental Health Perspectives, 118, 998-1003.
[10] Li, C., Zhao, Y. and Li, L.X. (2012) Exposure assessment of phthalates in non-occupational populations in China. Science of the Total Environment, 428, 60-69.
[11] Nanni, N., Fiselier, K. and Grob, K. (2011) Contamination of vegetable oils marketed in Italy by phthalic acid esters. Food Control, 22, 209-214.
[12] Shen, H.Y. (2005) Simultaneous screening and determination eight phthalates in plastic products for food use by sonicationassisted extraction/GC-MS methods. Talanta, 66, 734-739.
[13] Mario, V.R., Ivan, N., Giuseppe, C., et al. (2012) Evaluation of an analytical method for determining phthalate esters in wine samples by solid-phase extraction and gas chromatography coupled with ion-trap mass spectrometer detector. Analytical and Bioanalytical Chemistry, 402, 1373-1381.
[14] Shen, H.Y., Jiang, H.L., Mao, H.L., et al. (2007) Simultaneous determination of seven phthalates and four parabens in cosmetic products using HPLC-DAD and GC-MS methods. Journal of Separation Science, 30, 48-54.
[15] 熊金龙, 任静, 王未鲜 (2012) 气质联用法检测凹凸棒土中16种邻苯二甲酸酯类塑化剂的研究. 中国化工贸易, 1, 157159.
[16] Cavaliere, B., Macchione, B. and Sindona, G. (2008) Tandem mass spectrometry in food safety assessment: The determination of phthalates in olive oil. Journal of Chromatography A, 1205, 137-143.
[17] Dugo, G., Fotia, V. and Turco, V.L. (2011) Phthalate, adipate and sebacate residues by HRGC-MS in olive oils from Sicily and Molise (Italy). Food Control, 22, 982-988.
[18] Ye, C.W., Gao, J., Yang, C., et al. (2009) Development and application of an SPME/GC method for the determination of trace phthalates in beer using a calix[6]arene fiber. Analytica Chimica Acta, 641, 64-74.
[19] Silvia, L.F., Rafael, L., Soledad, C., et al. (2009) Surfactantcoated carbon nanotubes for the liquid-liquid extraction of phthalates and other migrants in virgin olive oils. Analytical and Bioanalytical Chemistry, 395, 737-746.
[20] Ma, Y.W., Hashi, Y., Ji, F., et al. (2010) Determination of phthalates in fruit jellies by dispersive SPE coupled with HPLC-MS. Journal of Separation Science, 33, 251-257.
[21] 沈昊宇, 应丽艳, 潘刚, 等 (2007) 固相萃取–气相色谱–质谱法同时测定化妆品中的邻苯二甲酸酯和对羟基苯甲酸酯. 色谱, 2, 272-275.
[22] 贾宁, 许恒智, 胡亚丽, 等 (2005) 固相萃取–气相色谱法测定北京市水样中的邻苯二甲酸酯. 分析实验室, 11, 18-21.
[23] 刘芃岩, 高丽, 申杰, 等 (2010) 固相微萃取–气相色谱法测定白洋淀水样中的邻苯二甲酸酯类化合物. 色谱, 5, 517520.
[24] 张璇, 陈大周, 汤桦, 等 (2012) 顶空固相微萃取/气相色谱-质谱法测定液态化妆品中8种增塑剂. 分析测试学报, 3, 317.
[25] Heaven, M.W. and Nash, D. (2012) Recent analyses using solid phase microextraction in industries related to food made into or from liquids. Food Control, 27, 214-227.
[26] Chen, H., Liu, X.J., Yang, C., et al. (2009) Determination of phthalates in beverages by headspace SPME-GC using Calix[6] arene fiber. Chromatography, 70, 883-890.
[27] Zhou, X., Shao, X., Shu, J.J., et al. (2012) Thermally stable ionic liquid-based sol-gel coating for ultrasonic extraction-solid-phase microextraction-gas chromatography determination of phthalate esters in agricultural plastic films. Talanta, 89, 129-135.
[28] 张前龙, 王宇, 曹云, 等 (2009) 食品塑料包装中酞酸酯类环境污染物气相色谱测定方法的研究. 中国卫生检验杂志, 12, 2833-2913.
[29] Feng, C.H. and Jiang, S.R. (2012) Micro-scale quantitation of ten phthalate esters in water samples and cosmetics using capillary liquid chromatography coupled to UV detection: effective strategies to reduce the production of organic waste. Microchimica Acta, 177, 167-175.
[30] 黄明元, 罗越文, 戴娟秀, 等 (2013) HPLC法测定白酒中十六种邻苯二甲酸酯. 中国卫生检验杂志, 13, 2724-2729.
[31] Carrillo, J.D., Martinez, M.P. and Tena, M.T. (2008) Determination of phthalates in wine by headspace solid-phase microextraction followed by gas chromatography-mass spectrometry use of deuterated phthalates as internal standards. Journal of Chromatography A, 1181, 125-130.
[32] Riosa, J.J., Moralesa, A. and Márquez-Ruizb, G. (2010) Headspace solid-phase microextraction of oil matrices heated at high temperature and phthalate esters determination by gas chromatography multistage mass spectrometry. Talanta, 80, 2076-2082.
[33] Farajzadeh, M.A., Djozan, D., Afshar, M.R., et al. (2012) Determination of phthalate esters in cow milk samples using dispersive liquid-liquid microextraction coupled with gas chromatography followed by flame ionization and mass spectro-metric detection. Journal of Separation Science, 35, 742-749.
[34] Feng, Y.L., Zhu, J.P. and Sensenstein, R. (2005) Development of a headspace solid-phase microextraction method combined with gas chromatography mass spectrometry for the determination of phthalate esters in cow milk. Analytica Chimica Acta, 538, 4148.
[35] Luo, Y.B., Yu, Q.W., Yuan, B.F., et al. (2012) Fast microextraction of phthalate acid esters from beverage, environmental water and perfume samples by magnetic multi-walled carbon nanotubes. Talanta, 90, 123-131.
[36] 李婷, 汤智, 洪武兴 (2012) 分散固相萃取–气相色谱–质谱法测定含油脂食品中17种邻苯二甲酸酯. 分析化学, 3, 391-396.
[37] Guart, A., Bono-Blay, F., Borrell, A., et al. (2011) Migration of plasticizersphthalates, bisphenol A and alkylphenols from plastic containers and evaluation of risk. Food Additives & Contaminants, 28, 676-685.
[38] 黄珂, 赵东豪, 黎智广, 等 (2011) 高效液相色谱–串联质谱法测定水中邻苯二甲酸酯. 海洋环境科学, 4, 591-593.
[39] 刘杰, 郁宏燕, 鲍立杰, 等 (2012) 液相色谱–串联质谱法测定饮料中16种邻苯二甲酸酯. 食品科学, 18, 211-215.
[40] Fankhauser-Noti, A. and Grob, K. (2006) Migration of plasticizers from PVC gaskets of lids for glass jars into oily foods: Amount of gasket material in food contact, proportion of plasticizer migrating into food and compliance testing by simu-lation. Trends in Food Science & Technology, 17, 105-112.
[41] Page, B.D. and Lacroix, G.M. (1995) The occurrence of phthalate ester and di-2-ethylhexyl adipate plasticizers in Canadian packaging and food sampled in 1985-1989: A survey. Food Additives & Contaminants, 12, 129-151.
[42] Guo, Y. and Kannan, K. (2012) Challenges encountered in the analysis of phthalate esters in foodstuffs and other biological matrices. Analytical and Bioanalytical Chemistry, 404, 25392554.