ACM  >> Vol. 4 No. 2 (June 2014)

    益气滋阴润肺汤结合西药治疗肺结核的临床疗效研究
    Clinical Study on the Therapeutic Effect of Western Medicine in the Treatment of Pulmonary Tuberculosis Combined with Yiqi Ziyin Runfei Decoction

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作者:  

谷婉萍,周玲霞,黄金鹏:浙江省中西医结合医院结核科,杭州

关键词:
中药西药肺结核疗效Chinese Herbal Western Medicine Tuberculosis Curative Effect

摘要:

目的:观察中西医结合方法治疗肺结核病的临床疗效。方法:将100例肺结核病的患者随机分为两组,其中治疗组57例及对照组43例。两组均予常规抗痨治疗;治疗组在常规治疗基础上加服益气滋阴润肺汤,疗程为6个月。治疗期间观察临床症状改善、痰菌转阴、空洞缩小及病灶吸收率等情况;观察两组患者治疗前后外周血IFN-γ(γ-干扰素)、白介素13(IL-13)、肿瘤坏死因子(TNF)、透明质酸(HA)的水平变化、药物不良反应改善情况。结果:治疗6个月后治疗组在痰菌转阴率、空洞缩小率、病灶吸收率、临床症状改善率等方面明显优与对照组(P < 0.05),差异有统计学意义。治疗6个月后两组患者血IL-13、IFN-γ水平较治疗前均有不同程度上升、TNF、HA水平较治疗前均有不同程度下降(P < 0.05),且治疗组上升、下降幅度明显优于对照组(P < 0.05),差异有统计学意义。治疗过程中出现的药物不良反应(肝功能损害、白细胞减少、胃肠道反应、皮疹、小便异常)治疗组明显低于对照组(P < 0.05),差异有统计学意义。结论:中西医结合方法治疗肺结核病的临床疗效优于单纯西医治疗。

Objective: To observe the clinical curative effect of traditional Chinese and Western medicine treatment of pulmonary tuberculosis. Method: To divide randomly 100 cases of pulmonary tu-berculosis into two groups, 57 cases in treatment group and 43 cases in the control group. The two groups were given conventional anti-tuberculosis treatment; the treatment group was based on routine treatment with Yiqi Ziyin Runfei decoction for 6 months. During the treatment, the im-provement of clinical symptoms, the negative conversion of sputum, diminished cavity and lesions absorption rate will be observed. Two groups were observed before and after treatment about level changes of peripheral blood IFN-γ (γ-interferon), interleukin 13 (IL-13), tumor necrosis factor (TNF), hyaluronic acid (HA), and the situation of drug reaction improvement. Results: After 6 months of treatment in treatment group, the sputum negative conversion rate, diminished rate of cavity, lesions absorption rate, clinical symptom improvement rate were significantly better than that in the control group (P < 0.05), and the difference was statistically significant. After 6 months of treatment in two groups of patients, serum IL-13, IFN-γ levels increased with different degrees, and TNF, HA levels decreased compared with that before treatment (P < 0.05). The degree of increase, decrease in the treatment group was significantly better than that in the control group (P < 0.05), and the difference was statistically significant. As to the adverse drug reactions during the treatment (liver function damage, white blood cell decrease, gastrointestinal reaction, rash, ab-normal urine) in treatment group was obviously less than that in the control group (P < 0.05), and the difference was statistically significant. Conclusion: The clinical curative effect of pulmonary tuberculosis treatment combining traditional Chinese medicine with Western medicine is better than that with pure western medicine treatment.

文章引用:
谷婉萍, 周玲霞, 黄金鹏. 益气滋阴润肺汤结合西药治疗肺结核的临床疗效研究[J]. 临床医学进展, 2014, 4(2): 22-26. http://dx.doi.org/10.12677/ACM.2014.42005