基本情况
季光，博士，上海中医药大学中医内科学教授、博士研究生导师、博士后合作导师，上海中医药大学脾胃病研究所创所所长，经方与现代中药融合创新全国重点实验室副主任，上海市炎癌转化病证生物学前沿科学中心首席科学家。中华中医药学会健康管理分会名誉主委、脾胃病分会副主委，中国老年学会和老年医学会健康管理分会主委，《Journal of Integrative Medicine》主编、《BMC Complementary Medicine and Therapies》副主编。
研究领域
中医药防治消化肝病
教育背景
1997年7月，毕业于上海中医药大学，获中医内科学博士学位
1994年7月，毕业于湖北中医学院，获中西医结合基础硕士学位
1991年7月，毕业于江苏省扬州医学院，获中西医结合临床学士学位
论文发表
1. yingying X, Wei Q, Guang J, Li Z, et al. Non-steroidal Anti-Inflammatory Drugs on Metabolic Dysfunction-Associated Steatotic Liver Disease: from Molecular Mechanisms to Potential Clinical Applications[J], crossref, 2025
2. Yanqun L, Haiping X, Ying G, Guang J, Tao W, et al. Sphingosine Kinase 2 in Cancer: A Review of Its Expression, Function, and Inhibitor Development.[J], International journal of biological macromolecules, 2025: 141392.
3. Jiaxuan W, Sijing X, Shengan Z, Yunuo Y, Jiashu P, Wenjun Z, Dan H, Guang J, Yanqi D, et al. Gan-Jiang-Ling-Zhu Decoction Improves Steatohepatitis Induced by Choline-Deficient-high-fat-diet Through the METTL14/N6-methyladenosine-mediated Ugt2a3 Expression[J], JOURNAL OF ETHNOPHARMACOLOGY, 2025, 339
4. Shu-Chang N, Yan-Hua J, Lu, Si-Si R, Guang J, Han-Chen X, et al. Mechanisms of Myeloid-Derived Suppressor Cell-Mediated Immunosuppression in Colorectal Cancer and Related Therapies[J], World Journal of Gastrointestinal Oncology, 2024, 16(5): 1690-1704.
5. Yunuo Y, Jiaxuan W, Wenjun Z, Guang J, Yanqi D, et al. Protein Posttranslational Modifications in Metabolic Diseases: Basic Concepts and Targeted Therapies[J], MEDCOMM, 2024, 5(10): n/a-n/a.
6. Jiaxuan W, Jiashu P, Wenjun Z, Guang J, Yanqi D, et al. The Role of N6-methyladenosine in Macrophage Polarization: A Novel Treatment Strategy for Non-Alcoholic Steatohepatitis[J], Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2024, 171: 116145-116145.
7. Ying G, Yanqun L, Guang J, Tao W, et al. Functional and Pathological Roles of Adenylyl Cyclases in Various Diseases[J], INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2024, 281
8. Xin Y, Yuesong X, Jie L, Ximing R, Zhihao G, Linfeng S, Lei Z, Li W, Guang J, Ruirui W, et al. Bile Acid-Gut Microbiota Imbalance in Cholestasis and Its Long-Term Effect in Mice.[J], mSystems, 2024, 9(7)
9. Xinyu S, Yalan X, Hualing S, Fen R, Nan T, Leping Z, Shenyu L, Jianying W, Lei Z, Shengfu Y, Guang J, Baocheng L, Na W, et al. Progress and Hotspot of Diet or Exercise Therapy in the Treatment of Non-Alcoholic Fatty Liver Disease[J], FRONTIERS IN NUTRITION, 2024, 11
10. Yunuo Y, Jiaxuan W, Lisheng W, Guang J, Yanqi D, et al. Copper Homeostasis and Cuproptosis in Health and Disease[J], MedComm, 2024, 5(10): n/a-n/a.
11. Yan-qun L, Cai-yun Z, Xia-zhen N, Ying G, Lei W, Guang J, Tao W, et al. Metabolomics in Cirrhosis: Recent Advances and Opportunities[J], CLINICA CHIMICA ACTA, 2024, 557
12. Haoxiang Z, Ling X, Yinhua L, Juan Y, Jihan H, Qingshan Z, Guang J, Lujin L, et al. Comparative Efficacy of NAFLD Therapies and Biomarker Associations: A Meta-Analysis Based on Liver Fat Content[J], Gastro Hep Advances, 2024
13. Yanqun L, Haiping X, Hongyu C, Ying G, Guang J, Tao W, et al. Metabolomics Advances in Chronic Atrophic Gastritis Diagnosis and the Integration of Traditional Chinese Medicine[J], Saudi Pharmaceutical Journal, 2024
14. Yu-Nuo Y, Li-Sheng W, Yan-Qi D, Guang J, et al. Evaluating the Efficacy of Immunotherapy in Gastric Cancer: Insights from Immune Checkpoint Inhibitors[J], World journal of gastroenterology, 2024, 30(32): 3726-3729.
15. Jiashu P, Jiaxuan W, Shengan Z, Kai W, Guang J, Wenjun Z, Yanqi D, et al. Targeted Metabolomics Revealed the Mechanisms Underlying the Role of Liansu Capsule in Ameliorating Functional Dyspepsia[J], JOURNAL OF ETHNOPHARMACOLOGY, 2024, 321
16. Gaoxuan S, Ying L, Lu, Lei W, Guang J, Hanchen X, et al. Therapeutic Potential of Traditional Chinese Medicine in the Prevention and Treatment of Digestive Inflammatory Cancer Transformation: Portulaca Oleracea L. As a Promising Drug[J], Journal of Ethnopharmacology, 2024, 327: 117999-117999.
17. Yanqi D, Wei W, Aiping L, Lisheng W, Guang J, et al. Editorial: Application of Genomics and Epigenetics in Disease and Syndrome Classification[J], Frontiers in Genetics, 2024, 15
18. Zhaozhou Z, Liqing D, Qiuchen J, Hao L, Zhenxing R, Guang J, Zhao-Xiang B, Ling Z, et al. The Landscape of Gut Microbiota and Its Metabolites: A Key to Understanding the Pathophysiology of Pattern in Chinese Medicine.[J], AMERICAN JOURNAL OF CHINESE MEDICINE, 2024, 52(01): 89-122.
19. Yujing L, Lu, Peiqiu C, Shengan Z, Yangxian X, Dan H, Guang J, Hanchen X, et al. Wogonin Inhibits Colorectal Cancer Proliferation and Epithelial Mesenchymal Transformation by Suppressing Phosphorylation in the AKT Pathway[J], AMERICAN JOURNAL OF CHINESE MEDICINE, 2024, 52(04): 1155-1172.
20. Chunlin L, Meng L, Wei S, Wenjun Z, Ziqi Z, Guang J, Li Z, et al. High Dietary Fructose Drives Metabolic Dysfunction-Associated Steatotic Liver Disease Via Activating Ubiquitin-Specific Peptidase 2/11Β-Hydroxysteroid Dehydrogenase Type 1 Pathway in Mice[J], International Journal of Biological Sciences, 2024, 20(9): 3480-3496.
21. Ziqi Z, Meng L, Guang J, Li Z, et al. Causal Relationship Between Sleep Apnea and Non-Alcoholic Fatty Liver Disease: A Mendelian Randomization Study.[J], European Journal of Clinical Investigation, 2023, 54(3)
22. Ziqi Zhang, Guang Ji, Meng Li. Glucokinase regulatory protein: a balancing act between glucose and lipid metabolism in NAFLD.[J], Frontiers in endocrinology, 2023, 14: 1247611-1247611.
23. Ziqi Zhang, Guang Ji, Meng Li. Glucokinase Regulatory Protein: a Balancing Act Between Glucose and Lipid Metabolism in NAFLD[J], Frontiers in Endocrinology, 2023, 14
24. Na W, Mofan F, Siran Y, Xinyu S, Nan T, Yalan X, Jianying W, Lei Z, Hualing S, Yi S, Guang H, Guang J, Baocheng L, et al. DNA Methylation of SMPD3-based Diagnostic Biomarkers of NASH and Mild Fibrosis.[J], Genes & diseases, 2023, 11(1): 99-102.
25. 余思雨,操颖,朱明哲,黄志艳,季光,张贵民 & 张莉.(2023).化滞柔肝颗粒减轻非酒精性脂肪性肝炎相关肝纤维化的机制研究.上海中医药杂志,57(02),41-50.DOI:10.16305/j.1007-1334.2023.2209029.
26. Wei Sheng, Guang Ji, Li Zhang. Immunomodulatory Effects of Inulin and Its Intestinal Metabolites.[J], Frontiers in Immunology, 2023, 14
27. Yanqi D, Ruohui X, Jiashu P, Xiaoli X, Shengan Z, Wenjun Z, Yangxian X, Guang J, et al. Dynamic Changes in DNA Methylation and Hydroxymethylation Revealed the Transformation of Advanced Adenoma into Colorectal Carcinoma.[J], Clinical and translational medicine, 2023, 13(3)
28. 李玲,季光,张彤,等.经典名方苓桂术甘汤复方制剂的研制[J].中成药,2023,45(10):3165-3172.DOI:10.3969/j.issn.1001-1528.2023.10.001.
29. Mingzhe Z, Xue W, Kai W, Zhiqiang Z, Yanqi D, Guang J, Fenghua L, Wenjun Z, et al. Lingguizhugan Decoction Improves Non-Alcoholic Steatohepatitis Partially by Modulating Gut Microbiota and Correlated Metabolites.[J], Frontiers in cellular and infection microbiology, 2023, 13
30. Caiyun Z, Hongjiao X, Junmin W, Gaoxuan S, Peilun D, Ying G, Hanchen X, Guang J, Tao W, et al. Exploring the Mechanism of Jianpi Huatan Recipe in Protecting Hepatocellular Carcinoma Based on Network Pharmacology[J], JOURNAL OF ETHNOPHARMACOLOGY, 2023, 317
31. Ying G, Peilun D, Junmin W, Caiyun Z, Guang J, Tao W, et al. Application of Metabolomics in Irritable Bowel Syndrome in Recent 5 Years.[J], International Immunopharmacology, 2023, 124
32. 张晟安,刘志栋,戴亮,李玲,党延启,周文君,王振中 & 季光.(2023).苓桂术甘汤的临床应用:1项系统性评价与Meta分析.中草药,54(14),4599-4614.DOI:10.7501/j.issn.0253-2670.2023.14.021.