基本情况

闫波，博士，教授，博士生导师，现任山东省心脏疾病诊疗重点实验室主任，中美转化医学联合实验室（济宁医学院-乔治华盛顿大学医学院）中方主任，济宁医学院附属医院中心实验室主任。

论文发表

1. Qin X, Xing Q, Ma L, Meng H, Liu Y, Pang S, Yan B. Genetic analysis of an enhancer of the NKX2-5 gene in ventricular septal defects. Gene. 2012 Oct 15; 508(1): 106-9
2. Huang J, Xu J, Pang S, Bai B, Yan B. Age-related decrease of the LAMP-2 gene expression in human leukocytes.Clin Biochem. 2012 Oct; 45(15): 1229-32
3.  Shan J, Pang S, Qiao Y, Ma L, Wang H, Xing Q, Wanyan H, Wu G, Yan B. Functional analysis of the novel sequence variants within TBX5 gene promoter in patients with ventricular septal defects. Transl Res. 2012 Sep; 160(3): 237-8
4. Shan J, Pang S, Wanyan H, Xie W, Qin X, Yan B. Genetic analysis of the SIRT1 gene promoter in ventricular septal defects. Biochem Biophys Res Commun. 2012 Sep 7; 425(4): 741-5
5. Cui Y, Wang H, Chen H, Pang S, Wang L, Liu D, Yan B. Genetic analysis of the SIRT1 gene promoter in myocardial infarction. Biochem Biophys Res Commun. 2012 Sep 21; 426(2): 232-6
6.  Pang S, Chen D, Zhang A, Qin X, Yan B. Genetic analysis of the LAMP-2 gene promoter in patients with sporadic Parkinson's disease. Neurosci Lett. 2012 Sep 20; 526(1): 63-7
7. Wang H, Chen D, Ma L, Meng H, Liu Y, Xie W, Pang S, Yan B. Genetic analysis of the TBX1 gene promoter in ventricular septal defects. Mol Cell Biochem. 2012 Jul 17. [Epub ahead of print]
8. Zhang A, Wang H, Qin X, Pang S, Yan B. Genetic analysis of SIRT1 gene promoter in sporadic Parkinson's disease. Biochem Biophys Res Commun. 2012 Jun 15; 422(4): 693-6
9. Wu G, Shan J, Pang S, Wei X, Zhang H, Yan B. Genetic analysis of the promoter region of the GATA4 gene in patients with ventricular septal defects. Transl Res. 2012 May; 159(5): 376-82
10. Qiao Y, Wanyan H, Xing Q, Xie W, Pang S, Shan J, Yan B. Genetic analysis of the TBX20 gene promoter region in patients with ventricular septal defects. Gene. 2012 May 25; 500(1): 28-31
11. Pang S, Shan J, Qiao Y, Ma L, Qin X, Wanyan H, Xing Q, Wu G, Yan B. Genetic and Functional Analysis of the NKX2-5 Gene Promoter in Patients With Ventricular Septal Defects. Pediatr Cardiol. 2012 May 11. [Epub ahead of print]
12. Yuan H, Yan B, Wang HH, Hua S, Hu A. Nitric oxide preserves XIAP and reduces hypoxia/reoxygenation-induced cardiomyocytes apoptosis via ERK1/2 activation. Biochem Biophys Res Commun. 2012 Apr 27; 421(1): 134-9
13. Wu G, Huang J, Feng X, Zhang A, Li J, Pang S, Gu K, Dong H, Zhang J, Gao H, Yan B. Decreased expression of lysosomal alpha-galactosiase A gene in sporadic Parkinson's disease. Neurochem Res. 2011 Oct;36(10):1939-44
14. Wu G, Liu L, Huang J, Pang S, Wei G, Cui Y, Yan B. Alterations of autophagic-lysosomal system in the peripheral leukocytes of patients with myocardial infarction. Clin Chim Acta. 2011 Aug 17; 412(17-18): 1567-71
15. Wu G, Pang S, Feng X, Zhang A, Li J, Gu K, Huang J, Dong H, Yan B. Genetic analysis of lysosomal alpha-galactosidase A gene in sporadic Parkinson's disease. Neurosci Lett. 2011 Aug 1; 500(1): 31-5
16. Wu G, Huang J, Wei G, Liu L, Pang S, Yan B. LAMP-2 gene expression in peripheral leukocytes is increased in patients with coronary artery disease. Clin Cardiol. 2011 Apr; 34(4): 239-43
17. Neilson KM, Pignoni F, Yan B, Moody SA. Developmental expression patterns of candidate cofactors for vertebrate six family transcription factors. Dev Dyn. 2010 Dec; 239(12): 3446-66
18. Yan B, Neilson KM, Moody SA. Microarray identification of novel downstream targets of FoxD4L1/D5, a critical component of the neural ectodermal transcriptional network. Dev Dyn. 2010 Dec; 239(12): 3467-80
19. Yan B, Neilson KM, Moody SA. Notch signaling downstream of foxD5 promotes neural ectodermal transcription factors that inhibit neural differentiation. Dev Dyn. 2009 Jun; 238(6): 1358-65
20. Yan B, Nelson KM, Moody SA. foxD5 plays a critical upstream role in regulating neural ectodermal fate and the onset of neural differentiation. Dev Biol 2009; 329(1): 80-95
21.  Schlosser G, Awtry T, Brugmann SA, Jensen ED, Neilson K, Ruan G, Stammler A, Voelker D, Yan B, Zhang C, Klymkowsky MW, Moody SA. Eya1 and Six1 promote neurogenesis in the cranial placodes in a SoxB1-dependent fashion. Dev Biol. 2008 Aug 1 ;320(1): 199-214. Epub 2008 May 20
22. Huang S, Yan B, Sullivan SA, Moody SA. Noggin signaling from Xenopus animal blastomere lineages promotes a neural fate in neighboring vegetal blastomere lineages. Dev Dyn. 2007 Jan; 236(1): 171-83
23.  Yan B, Moody SA. The competence of Xenopus blastomeres to produce neural and retinal progeny is repressed by two endo-mesoderm promoting pathways. Dev Biol 2007; 305: 103-119
24. Zaghloul N, Yan B, Moody SA. Step-wise specification of retinal stem cells in early embryogenesis. Biol Cell 2005; 97: 321-327
25. Yan B, Raben N, Plotz P. The human acid alpha-glucosidase gene is a novel target of the Notch-1/Hes-1 signaling pathway. J Biol Chem. 2002; 277(33): 29760-29764
26. Yan B, Raben N, Plotz PH. Hes-1, a known transcriptional repressor, acts as a transcriptional activator for the human acid alpha-glucosidase gene in human fibroblast cells. Biochem Biophys Res Commun. 2002; 291(3): 582-587
27. Raben N, Lu N, Nagaraju K, Rivera Y, Lee A, Yan B, Byrne B, Meikle PJ, Umapathysivam K, Hopwood JJ, Plotz PH. Conditional tissue-specific expression of the acid alpha-glucosidase (GAA) gene in the GAA knockout mice: implications for therapy. Hum Mol Genet. 2001; 10(19): 2039-2047
28. Yan B, Raben N, Lu N, Plotz PH. Identification and characterization of a tissue-specific silencer element in the first intron of the human acid maltase gene. Hum Genet. 2001; 109(2): 186-190
29. Yan B, Heus J, Lu N, Nichols RC, Raben N, Plotz PH. Transcriptional regulation of the human acid alpha-glucosidase gene. Identification of a repressor element and its transcription factors Hes-1 and YY1. J Biol Chem. 2001; 276(3): 1789-1793
30. Tao JZ, Liu DP, Wei QZ, Zhai JB and Yan B. Effect of small erythroid enhancer fragment on expression of transferred b-globin in MEL cells. Chinese Medical Journal (English Edition) 1997; 110: 711