基本情况

高钟镐,博士,中国医学科学院北京协和医学院药物研究研究员。2001年加入美国Vladimir P Torchilin教授实验组从事博士后研究,主要研究方向为药物控释和靶向制剂的研究。2003年到2008年被聘为犹他大学助教授,主要从事肿瘤靶向纳米制剂和超声微泡靶向给药系统研究。


研究领域

生物物理药剂学、药物控释和靶向制剂的研究、肿瘤靶向纳米制剂和超声微泡靶向给药系统研究、分子药剂学研究


论文发表

  1. Wei Huang, Ming Lv, Zhonggao GaoPolyethylenimine grafted with diblock copolymers of polyethylene glycol and polycaprolactone as siRNA delivery vector.J Control Release. 2011, 152, 143-145 (7.16)
  2. 陈卫,金明姬,高钟镐,王丽萍,朴海峰,pH 敏感性的TAT肽修饰胶束的制备及其体外评价,药学学报,2011465):599-604
  3. 杨飞飞李云飞高钟镐,siRNA非病毒递送载体的研究现状药学学报,2011,46(12):1436-1443
  4. Zhong-Gao Gao, Li Tian, Jun Hu, In-Suh Park, You Han Bae, Prevention of Metastasis in a 4T1 Murine Breast Cancer Model byDoxorubicin Carried by Folate Conjugated pH Sensitive Polymeric Micelles, J Control Release. 2011, 152, 84-9. (7.16)
  5. Natalya Rapoport, Kweon-Ho Nam, Roohi Gupta, Zhongao Gao, Praveena Mohan, Allison Payne, Nick Todd , Xin Liu , Taeho Kim, Jill Shea, Courtney Scaife, Dennis L. Parker, Eun-Kee Jeong, Anne M. Kennedy, Ultrasound-mediated tumor imaging and nanotherapy using drug loaded, block copolymer stabilized perfluorocarbon nanoemulsions. J Control Release. 2011, 153(1): 4-15
  6. 黄伟邓亮生高钟镐王玉丽等人胰岛素样生长因子-I基因P1启动子区域CA微卫星多态性对启动子活性的影响解放军医学杂志,2010,35(9):1113-1116
  7. 黄伟崔光华王玉丽贺俊峰周旭高钟镐,PicoGreen荧光法结合茚三酮比色法测定载pDNA壳聚糖纳米粒中pDNA的包封率和载药量药物分析杂志,2010,30(2):226-229
  8. 黄伟,吕明,李保卫,邵荣光,高钟镐。大鼠脑胶质瘤荧光素酶动物模型建模细胞株C6-Luc的构建,解放军医学杂志,2011361):35-38
  9. Wei HuangMing LvZhong Gao GaoSynthesis of polyethylenimine grafted with copolymers of polyethylene glycol and polycaprolactone and its potential for siRNA deliveryChinese Chemical Letters. 2011, 22(6): 749-752
  10. 黄伟,吕明,高钟镐,金明姬,杨长青。mPEG-PCL-g-PEI聚合物纳米粒介导的小干扰RNA递送。药学学报2011,46(3):344-349
  11. 吕明,黄伟,高钟镐。聚乙烯亚胺及其衍生物介导siRNA递送的研究进展。中国药学杂志,2011,46281-84
  12. Dong-Han Han, Zhe-Hu Jin, Yan-Zhe Jin, Xue-zhe Yin,Yuan-Yuan Shen,and Zhong-Gao Gao.Thermal Reversible Microemulsion System for Poorly WaterSoluble YH439 for Oral Delivery.Chem.Pharm.Bull.,2010,58(1),11-15. (1.623)
  13. Gao, Zhong-Gao, Jin, Zhe-Hu, Yin, Xue-Zhe, Tian, Li. Multifunctional Nanparticles for Targeting Cancer Therapy. J NANOSCI NANOTECHNO, 2010, 10 (11)7743-6
  14. D. Kim, Z.G. Gao, E.S. Lee, Y.H. Bae. In vivo evaluation of doxorubicin-loaded polymeric micelles targeting folate receptors and early endosomal pH in drug-resistant ovarian cancer, Mol. Pharmaceutics. 20096(5): 1353-62
  15. N. Rapoport, K.H. Nam, Z. Gao, and A. Kennedy. Application of Ultrasound for Targeted Nanotherapy of Malignant Tumors. Acoustical Physics, 2009, 55: 594-601
  16. 沈圆圆高钟镐超声微泡作为基因或药物载体的研究进展药学学报,2009,44(9): 961-966
  17. 全毅,赵春植,韩东汉,高钟镐药物透过血脑屏障靶向传递系统的研究国际神经病学神经外科学杂志,2009365):466-473
  18. 全毅,黄伟,邵荣光,韩东汉,高钟镐,C6/Wistar大鼠脑胶质瘤模型的建立与评估,中华神经外科杂志(已录用)
  19. 全美燕,全毅,韩东汉,吕明,高钟镐,C6-Luc大鼠胶质瘤细胞株成瘤实验的研究,吉林大学学报医学版(已录用)
  20. Eun Seong Leea, 1, Zhonggao Gaoa, Dongin Kima, Kyeongsoon Parkb, Ick Chan Kwonb and You Han Bae 2008, Super pH-sensitive multifunctional polymeric micelle for tumor pH(e) specific TAT exposure and multidrug resistance. J Control Release 2008, 129(3): 228-236