基本资料
李乾斌，博士，中南大学药学院药物化学系副教授，硕士研究生导师。

社会职务
美国化学会会员
中南大学药物分子设计与研究中心副主任
湖南省高校“创新药物研究与开发”产学研合作示范基地副主任

研究方向
1、基于结构的合理药物设计及先导化合物的发现
2、基于细胞因子或酶的小分子抗纤维化化合物的研究与开发
3、基于细胞信号转导通路的抗肿瘤药物的设计、合成及构效关系研究

主要经历
2010/04－至今，副教授，硕士生导师，中南大学药学院药物化学系
2008/03－2010/3，博士后研究员，美国弗吉尼亚联邦大学药学院
2003/09－2008/12，博士，山东大学药学院药物化学专业

1999/09－2003/06，学士，山东大学药学院药物化学专业


科研项目
主持并参与了10余项科研项目，其中主持国家自然基金1项，教育部博士点基金1项，湖南省科技计划1项，中南大学“自由探索计划”1项。参与国家高技术研究发展计划（863计划）专题课题，国家科技重大专项“重大新药创制”，国家自然科学基金重大研究计划及面上项目多项。近年来，在国内外相关领域的学术期刊上发表论文30余篇，已获发明专利两项，专利申请两项。

发表论文

  1. Li, Q.; Fang, H.; Wang, X.; Hu, G.; Wang, Q.; Xu, W. Novel potent 2,5-pyrrolidinedione peptidomimetics as aminopeptidase N inhibitors. Design, synthesis and activity evaluation. Bioorg. Med. Chem. Lett. 2012, 22, 850-853.
  2. Wu, L.; Liu, B.; Li, Q.; Chen, J.; Tao, L.; Hu, G. Design, Synthesis and Anti-fibrosis Activity Study of N1-Substituted Phenylhydroquinolinone Derivatives. Molecules 2012, 17, 1373-1387.
  3. Wu, C.; Hu, Y.; Li, Q.; He, L.; Chen, J.; Cheng, Z.; Li, Y.; Hu, G. Synthesis, Pharmacokinetics, and Pharmacodynamics Studies of Valsartan Peptide Derivatives. Arch. Pharm. Weinheim. 2012, 345, 393-400.
  4. Liu, K.; Rao, W.; Parikh, H.; Li, Q.; Guo, T. L.; Grant, S.; Kellogg, G. E.; Zhang, S. 3,5-Disubstituted-thiazolidine-2,4-dione analogs as anticancer agents: design, synthesis and biological characterization. Eur. J. Med. Chem. 2012, 47, 125-137.
  5. Chen, J.; Lu, M. M.; Liu, B.; Chen, Z.; Li, Q. B.; Tao, L. J.; Hu, G. Y. Synthesis and structure-activity relationship of 5-substituent-21H.-pyridone derivatives as anti-fibrosis agents. Bioorg. Med. Chem. Lett. 2012. 22, 2300-2302.
  6. Yuan, Y.; Zhang, X.; Li, Q.; Xu, W. Design, synthesis and bioactivity evaluation of N-substituted-2,6-dioxopiperidin derivatives as aminopeptidase N (APN/CD13) inhibitors. Chinese J. Med. Chem. 2011, 21, 53-56.
  7. Zhang, X.; Fang, H.; Zhu, H.; Wang, X.; Zhang, L.; Li, M.; Li, Q.; Yuan, Y.; Xu, W. Novel aminopeptidase N APN/CD13. inhibitors derived from 3-phenylalanyl-N'-substituted-2,6-piperidinedione. Bioorg. Med. Chem. 2010, 18, 5981-5987.
  8. Li, Q.; Wu, J.; Zheng, H.; Liu, K.; Guo, T. L.; Liu, Y.; Eblen, S. T.; Grant, S.; Zhang, S. Discovery of 3-2-aminoethyl.-5-3-phenyl-propylidene.-thiazolidine -2,4-dione as a dual inhibitor of the Raf/MEK/ERK and the PI3K/Akt signaling pathways. Bioorg. Med. Chem. Lett. 2010, 20, 4526-4530.
  9. Li, Q.; Fang, H.; Wang, X.; Xu, W. Novel cyclic-imide peptidomimetics as aminopeptidase N inhibitors. Structure-based design, chemistry and activity evaluation. II. Eur. J. Med. Chem. 2010, 45, 1618-1626.
  10. Cui, S. X.; Qu, X. J.; Gao, Z. H.; Zhang, Y. S.; Zhang, X. F.; Zhao, C. R.; Xu, W. F.; Li, Q. B.; Han, J. X. Targeting aminopeptidase N APN/CD13. with cyclic-imide peptidomimetics derivative CIP-13F inhibits the growth of human ovarian carcinoma cells. Cancer Lett. 2010, 292, 153-162.
  11. Li, Q.; Fang, H.; Wang, X.; Hu, L.; Xu, W. Novel cyclic-imide peptidomimetics as aminopeptidase N inhibitors. Design, chemistry and activity evaluation. Part I. Eur. J. Med. Chem. 2009, 44, 4819-4825.
  12. Li, Q.; Al-Ayoubi, A.; Guo, T.; Zheng, H.; Sarkar, A.; Nguyen, T.; Eblen, S. T.; Grant, S.; Kellogg, G. E.; Zhang, S. Structure-activity relationship SAR. studies of 3-2-amino-ethyl.-5-4-ethoxy-benzylidene.-thiazolidine-2,4-dione: development of potential substrate-specific ERK1/2 inhibitors. Bioorg. Med. Chem. Lett. 2009, 19, 6042-6046.
  13. Chen, L.; Li, Q.; Zhu, H.; Fang, H.; Xu, W. Design, synthesis and activity study of aminopeptidase N targeted N-substituted-2,5-dioxopyrrolidin peptidomimetics. Chinese J. Med. Chem. 2009, 19, 174-180.
  14. Chen, M. H.; Cui, S. X.; Cheng, Y. N.; Sun, L. R.; Li, Q. B.; Xu, W. F.; Ward, S. G.; Tang, W.; Qu, X. J. Galloyl cyclic-imide derivative CH1104I inhibits tumor invasion through suppressing matrix metalloproteinase activity. Anticancer. Drugs 2008, 19, 957-965.
  15. Li, Q.; Fang, H.; Xu, W. Novel 3-galloylamido-N'-substituted -2,6-piperidinedione-N-acetamide peptidomimetics as metalloproteinase inhibitors. Bioorg. Med. Chem. Lett. 2007, 17, 2935-2938.
  16. Li, Q.; Xu, W. Novel anticancer targets and drug discovery in post genomic age. Curr Med Chem Anticancer Agents 2005, 5, 53-63.
  17. Xu, W.; Li, Q. Progress in the development of aminopeptidase N APN/CD13. inhibitors. Current Medicinal Chemistry-Anticancer Agents 2005, 5, 281-301.

发明专利

  1. 徐文方，李乾斌，环酰亚胺类肽金属蛋白酶抑制剂及其应用.2009.11，ZL200610146207.5
  2. 徐文方，李乾斌，方浩，王学建.α-氨基酰环酰亚胺类肽金属蛋白酶抑制剂及其应用.2012.10，ZL200910020656.9