基本情况

吴亚林，厦门大学眼科研究所，教授、博士生导师。

主要经历

2015.8─至今 教授、博士生导师，厦门大学眼科研究所

2012.5─2015.8 特聘教授，浙江大学医学院附属第二医院眼科中心
2011.8─2015.5 特聘研究员、博士生导师，浙江大学药学院

2007.12─2011.6 博士后，美国哥伦比亚大学眼科系

2007.4─2007.11 博士后，美国哥伦比亚大学化学系

2002.9─2007.3 理学博士学位，浙江大学化学系

1998.9─2002.6 工学学士学位，南京工业大学制药与生命科学学院

研究方向

年龄相关性视网膜黄斑变性的致病机理及治疗方法；年龄相关性视网膜黄斑变性靶向治疗的药物研究与开发；视觉信号转导通路。

代表性论文（*通讯作者）

1. Li J, Cai X, Xia Q, Yao K, Chen J, Zhang Y, Naranmandura H, Liu X, and Wu Y*. Involvement of endoplasmic reticulum stress in all-trans-retinal induced retinal pigment epithelium degeneration. Toxicol. Sci. 2015, 143(1), 196-208.
2. Zhao J, Yao K, Jin Q, Jiang K, Chen J, Liu Z, Li J, and Wu Y*. Preparative and biosynthetic insights into pdA2E and isopdA2E, retinal-derived fluorophores of retinal pigment epithelial lipofuscin. Invest. Ophthalmol. Vis. Sci. 2014, 55(12), 8241-8250.
3. Wu Y*, Jin Q, Yao K, Zhao J, Chen J, Wu X, Gan L, Li J, Song X, Liu X, and Cai X. Retinal metabolism in humans induces the formation of an unprecedented lipofuscin fluorophore 'pdA2E'. Biochem. J. 2014, 460(3), 343–352.
4. Li J, Yao K, Yu X, Dong X, Gan L, Luo C, and Wu Y*. Identification of a novel lipofuscin pigment (iisoA2E) in retina and its effects in the retinal pigment epithelial cells. J. Biol. Chem.2013, 288(50), 35671–35682.
5. Wu Y, Zhou J, Fishkin NE, Rittman BE, and Sparrow JR. Enzymatic degradation of A2E, a retinal pigment epithelial lipofuscin bisretinoid. J. Am. Chem. Soc. 2011, 133(4), 849–857.
6. Wu Y, Yanase E, Feng X, Siegel M, and Sparrow JR. Structural characterization of bisretinoid A2E photocleavage products and implications for age-related macular degeneration. Proc. Natl. Acad. Sci. U.S.A. 2010, 107(16), 7275–7280.
7. Wu Y, Fishkin NE, Pande A, Pande J, and Sparrow JR. Novel lipofuscin bisretinoids prominent in human retina and in a model of recessive Stargardt disease. J. Biol. Chem. 2009, 284(30), 20155–20166.
8. Chen X*, Ye Y, Cheng H, Jiang Y, and Wu Y*. Thermal effects on the stability and antioxidant activity of an acid polysaccharide conjugate derived from green tea. J. Agric. Food Chem. 2009, 57(13), 5795–5798.