基本情况

王钊，现为清华大学医学院药理学研究室主任/教授，清华大学生命科学学院双聘教授/博士生导师。曾任清华大学科研院副院长。

研究领域

药理学，尤其是衰老的分子细胞药理学以及药物干预衰老的机制研究，以及神经和代谢药理学以及中药现代化研究

教育背景

1993年4月至1996年3月 博士，日本国立冈山大学大学院自然科学研究科

1990年6月至1993年3月 硕士，日本国立冈山大学大学院药学研究科

1984年9月至1987年8月 硕士，中国北京中医药大学基础医学院

1978年3月至1983年1月 学士，中国河南中医学院医疗系

工作经历

2004年1月至今        教授，博士生导师，中国清华大学医学院

1998年5月至今        副教授、教授、双聘教授，中国清华大学生命科学学院

2006年9月至2007年6月 访问教授，美国纽约大学西奈山医学院

1996年4月至1998年4月 助理教授，日本国立冈山大学医学部

1987年8月至1990年5月 讲师，中国北京中医药大学基础医学院

论文发表

1. Junjun Jiang, MingchaoXie, Ryosuke Fuji, Shangfeng Liu, Xiaobei Yin, Genlin Li, Zhao Wang*.SPATA4counteractsetoposide-inducedapoptosisviamodulatingBcl-2familyproteinsin HeLa cells. Biol. Pharm. Bull., Accepted(2015)
2. Zhuoran Wang, Lu Zhang,  Yaru Liang, Chi Zhang, Zhiyu Xu, Lang Zhang, Ryosuke  Fuji, Wei Mu, Liyuan Li, Junjun Jiang, Yong Ju, and Zhao Wang*.Cyclic AMP Mimic the Anti-aging Effects of Calorie Restriction by Up-Regulation on Sirtuins.Sci. Rep. 5, 12012; doi: 10.1038/srep12012 (2015)
3. Lu Zhang, Zhuoran Wang, Yulong Chen, Chi Zhang, ShipingXie, Lihua Han,Zhao Wang*.Gender Differences Study in Response to Long-term Antiretroviral Therapy of HIV viaLabel-free Proteomic Analysis of PBMCs. Journal of Proteomics, 126(3): 46-53 (2015)
4. Yaru Liang, Chang Liu, Zhuoran Wang, Qiongye Dong, Xiaowo Wang, and Zhao Wang*. Meta-analytic Insights into the Effects of Different Anti-aging Drugs on Survival Curves of Caenorhabditiselegans. SCIENTIA SINICA Vitae. 45(5):479-487 (2015) Chinese.
5. Xiaoyan Wang, Kenichi Harimoto, Ryosuke Fuji, Jing Liu, Liyuan Li, Pan Wang, Toshihiro Akaike, Zhao Wang*. Pinctadafucata mantle gene 4 (PFMG4) from pearl oyster mantle enhances osteoblast differentiation. BiosciBiotechnolBiochem. 2014 Dec 8:1-8. [Epub ahead of print] (2014)
6. Zhuoran Wang, Lu Zhang, Zhiyu Xu, Yaru Liang, Yong Ju, Zhao Wang*. Rolipram rescues oxidative stress-induced premature phenotypes by SIRT6-dependent NF-kappa B inhibition. Actapharmacologicasinica. 34(S): 156-156 (2013)
7. Jing Du, Yu Liang, Feng Xu, Bing Sun, Zhao Wang*. Trehalose rescues Alzheimer's disease phenotypes in APP/PS1 transgenic mice. J Pharm Pharmacol. 65(12):1753-6 (2013)
8. Junjun Jiang, Nannan Zhang, Hiroshi Shiba, Liyuan Li, Zhao Wang*. Spermatogenesis Associated 4 Promotes Sertoli Cell Proliferation Modulated Negatively by Regulatory Factor X1. PLoS ONE. 8(10): e75933. doi:10.1371/journal.pone.0075933 (2013)
9. Lang Zhang, Haoyue Yu, Pan Wang, Qingyang Ding, ZhaoWang*. Screening of transcription factors with transcriptional initiation activity. Gene. 531: 64-70 (2013)
10. Lang Zhang, Pan Wang, Qingyang Ding, Zhao Wang*. Transcriptional directionality of the human insulin-degrading enzyme promoter. Mol Cell Biochem. 382: 237-242  (2013)
11. Cong Cheng, Weiguang Li, Zheng Zhang, Shohei Yoshimura, QinyuHao, Chi Zhang and Zhao Wang*. MicroRNA-144 Is Regulated by Activator Protein-1 (AP-1) and Decreases Expression of Alzheimer’s Disease-related A DisintegrinAndMetalloprotease 10 (ADAM10). J Biol Chem. 384 (3): 357-361  (2013)
12. Lang Zhang, Qingyang Ding, Pan Wang, Zhao Wang*.An upstream promoter element blocks the reverse transcription of the mouse insulin-degrading enzyme gene. BiochemBioph Res Co. 430(1): 26-31  (2013)
13. Lang Zhang, Qingyang Ding, Zhao Wang*.Nuclear Respiratory Factor 1 Mediates the Transcription Initiation of Insulin-Degrading Enzyme in a TATA Box-Binding Protein-Independent Manner. PLoS ONE. 7(8):e42035 (2012)
14. Xueping Wu, Yongsheng Cheng, Tian Li, Zhao Wang, and Jin-Yuan Liu*. In vitro identification of DNA-binding motif for the new zinc finger protein AtYY1. ActaBiochimBiophys Sin (Shanghai). 44(6):483-9. (2012)
15. JunweiGuo, Fangli Ren, Yinyin Wang, Shan Li, Zhengrong Gao, Xiaoyan Wang, HongxiuNing, Jianguo Wu, Yi Li, Zhao Wang, Shek Man Chim, Jiake Xu, Zhijie Chang*. miR-764-5p promotes osteoblast differentiation through inhibition of CHIP/STUB1 expression. J Bone Miner Res. 27 (7): 1607-18 (2012)
16. Jiyong Zhang, Qiuying Luan, Yanze Liu, David Y-W Lee, Zhao Wang*: A Comparison of the Diastereoisomers, Silybin A and Silybin B, on the Induction of Apoptosis in K562 cells. Natural Product Communications. (2011)[in press]
17. Xiaoyan Wang, Kenichi Harimoto, SijieXie,Hao Cheng, Jing Liu, Stephen Hinshaw,Zhijie Chang, Zhao Wang*. Spata4 promotes osteoblast differentiation through Erk-activated Runx2 pathway. J Bone Miner Res.26 (8): 1964-1973 (2011)
18. Xiaoyan WANG, Shangfeng LIU, Zhao WANG*.Pinctadafucata mantle gene 5 (PFMG5) from pearl oyster mantle inhibits osteoblast differentiation. Biosci Biotech Bioch. 75 (5): 991-993 (2011)
19. Xiaoyan Wang, Shangfeng Liu, LipingXie, Rongqing Zhang, Zhao Wang*. Pinctadafucata mantle gene 3 (PFMG3) promotes differentiation in mouse osteoblasts (MC3T3-E1). Comp BiochemPhysB. 158(2):173-180 (2011)
20. Huaqiang Cao*,Lu Zhang,He Zheng,and Zhao Wang*. Hydroxyapatite Nanocrystals for Biomedical Applications. J. Phys. Chem. C.114: 18352–18357 (2010)
21. Xiaoyan WANG, Kenichi HARIMOTO, Sijia XIE, Hao CHENG, Jing LIU, Zhao WANG*. Matrix Protein Biglycan Induces Osteoblast Differentiation through Extracellular Signal-Regulated Kinase and Smad Pathways. Biol. Pharm. Bull., 33(11):1891-1897 (2010)
22. Jing Du, Lang Zhang,Shubo Liu, Zhao Wang*. Palmitic acid and docosahexaenoic acid opposingly regulate the expression of insulin-degrading enzyme in neurons. Die Pharmazie. 65 (3): 231-232 (2010)
23. Hong Xie, Hui Zhu, Cong Cheng, Yu Liang, Zhao Wang*. Echinacoside Cell senescence MRC-5 Cell Cycle Reactive oxygen species DNA damage. Die Pharmazie.64 (11): 752-754 (2009)
24. Jing Du, Lang Zhang, Zhao Wang*. Testosterone inhibits the activity of PPAR in a transcriptional transaction assay. Die Pharmazie.64 (10): 692-693 (2009)
25. Jianbin Yan, Chi Zhang, Min Gu, Zhiyan Bai, Weiguo Zhang, Tiancong Qi, Zhiwei Cheng, Wen Peng, Haibin Luo, Fajun Nan*, Zhao Wang*, and DaoxinXie*. The ArabidopsisCoronatine Insensitive 1 Protein is a Jasmonate Receptor. Plant Cell. 21(8): 2220-2236 (2009)
26. Jing Du, Junlei Chang, SongxiGuo, Qing Zhang, Zhao Wang*. ApoE4 Reduces the Expression of Adegrading enzyme IDE by Activating the NMDA Receptor in Hippocampal Neurons. Neuroscience Letters.464 (2): 140-145 (2009)
27. Jing Du, Zhao Wang*. Therapeutic potential of lipase inhibitor orlistat in Alzheimer's disease. Medical Hypotheses.73 (5): 662-663  (2009)
28. Hao Gao, Feng Zhao, Guo-Dong Chen, Shao-Dan Chen, Yang Yu, Zhi-Hong Yao, Brad W.C. Lau, Zhao Wang, Jin Li, Xin-Sheng Yao*. Bidesmosidetriterpenoid glycosides from Stauntoniachinensis and relationship to anti-inflammation. Phytochemistry. 70: 795-806 (2009)
29. Jing Du, Bing Sun, Kui Chen, Li Fan, Zhao Wang*. Antagonist of Peroxisome Proliferator-activated Receptor <gamma> Induces Cerebellar Amyloid-<beta> Levels and Motor Dysfunction in APP/PS1 Transgenic Mice. BiochemBioph Res Co.384 (3): 357-361  (2009)
30. Zong-Chun Yi*, Yan-Ze Liu, Hai-Xia Li, Zhao Wang*. Chebulinic acid and tellimagrandin I inhibit DNA strand breaks by hydroquinone/Cu(II) and H2O2/Cu(II), but potentiate DNA strand breaks by H2O2/Fe(II). Toxicology in Vitro. 23 (4) 667–673 (2009)
31. Jing Du, Bing Sun, Kui Chen, Lang Zhang, Shubo Liu, QingquanGu, Li Fan, Nanming Zhao, Zhao Wang*. Metabolites of Neurons Play Essential Role in Pathogenesis of Alzheimer's Disease. PLoS ONE.4 (5): e5530 (2009)
32. Jing Du, Lang Zhang, Shubo Liu, Chi Zhang, Xiuqing Huang, Jian Li, Nanming Zhao, Zhao Wang*. PPAR Transcriptionally Regulates the Expression of Insulin Degrading Enzyme in Primary Neurons. BiochemBioph Res Co.383 (4): 485-490  (2009)
33. Zong-Chun Yi*, Yan-Ze Liu, Hai-Xia Li, Zhao Wang*. Prooxidant action of chebulinic acid and tellimagrandin I: Causing copper-dependent DNA strand breaks. Toxicology in Vitro. 23 (3) 425–431 (2009)
34. Qingzhi Wu, Huaqiang Cao*, Qiuying Luan, Jiyong Zhang, Zhao Wang*, Jamie H. Warner, and Andrew A. R. Watt. Biomolecule-Assisted Synthesis of Water-Soluble Silver Nanoparticles and Their Biomedical Applications. Inorganic Chemistry. 47 (13) 5882-5888 (2008)
35. Xue ZHANG, Feng-Juan TU, Hai-Yang YU, Nai-Li WANG, Zhao WANG, and Xin-Sheng YAO. Copacamphane, Picrotoxane and CyclocopacamphaneSesquiterpenes from Dendrobiumnobile. Chem. Pharm. Bull. 56 (6) 854-857 (2008)
36. Gao H, Wang Z, Yang L, Yu Y, Yao ZH, Wang NL, Zhou GX, Ye WC, Yao XS. Five new bidesmosidetriterpenoidsaponins from Stauntoniachinensis. Magnetic Resonance in Chemistry. 46 (7) 630-637 (2008)
37. Gao H, Wang Z, Yao ZH, Wu N, Dong HJ, Li J, Wang NL, Ye WC, Yao XS. Unusual nortriterpenoid glycosides from Stauntoniachinensis. Helvetica chimacaacta. 91 (3) 451-459 (2008)
38. Min Fu, Ruxin Li, Li Fan, Guowei He, Kent L Thornburg, Zhao Wang*: Sarcoplasmic Reticulum Ca2+ Release Channel Ryanodine Receptor (RyR2) Plays a Crucial Role in Aconitine-induced Arrhythmias. Biochemical Pharmacology. 75 (11) 2147-2156 (2008)
39. Jinghua Jin, Yu Liang, Hong Xie, Xue Zhang, Xinsheng Yao, Zhao Wang*: Dendroflorin Retards the Senescence of MRC-5 Cells. Die Pharmazie.63 (4) 321-323 (2008)
40. Xue Zhang, Hong-Wei Liu, Hao Gao, Hui-Ying Han, Nai-Li Wang, Hou-Ming Wu, Xin-Sheng Yao, Zhao Wang*: Nine New Sesquiterpenes from Dendrobiumnobile. Helvetica ChimicaActa. 90 (12): 2386-2394 (2007)
41. MingchaoXie, Chao Ai, Shangfeng Liu, Shixin Tao, Zhao Wang*: Cloning and characterization of chicken SPATA4 gene and analysis of its specific expression. Molecular and Cellular Biochemistry.306 (1-2): 79-85  (2007)
42. Haifeng Chen, Guanghui Wang, Naili Wang, Mengsu Yang, Zhao Wang, Xiaowei Wang, Xinsheng Yao: New furostanolsaponins from the bulbs of Allium Macrostemon Bunge and their Cytotoxic activity. Pharmazie. 62 (7): 544-548 (2007)
43. Min Fu, Meng Wu, Jifeng Wang, YanjiangQiao, Zhao Wang*: Disruption of the Intracellular Ca2+ Homeostasis in the Cardiac Excitation-Contraction Coupling is a Crucial Mechanism of Arrhythmic Toxicity in Aconitine-induced Cardiomyocytes. BiochemBioph Res Co.354 (4): 929-936  (2007)
44. Liu Hai-Luo, Liu Shang-Feng, Ge Ye-Jing, Liu Jing, Wang Xiao-Yan, Xie Li-Ping, Zhang Rong-Qing, Zhao Wang*: Identification and characterization of a biomineralization related gene PFMG1 highly expressed in the mantle of pinctadafucata. Biochemistry. 46 (3): 844-851  (2007)
45. Min Fu, Meng Wu, Ji-feng Wan, Yan-jiangQiao, Zhao Wang*: Toxicological Mechanisms of Aconitum Alkaloids. Pharmazie. 61 (9)735-741 (2006)
46. Zong-Chun Yi, Zhao Wang*, Hai-Xia Li, Yan Yin, Feng-Yuan Zhuang, and Yu-Bo Fan: Tellimagrandin I enhances gap junctional communication and attenuates the tumor phenotype of human cervical carcinoma HeLa cells in vitro. Cancer Letters. 242(1)77-87 (2006)
47. Shang-feng Liu, Chao Ai, Zhong-qi Ge, Hai-luo Liu, Bo-wen Liu, Shan He, Zhao Wang*: Molecular cloning and bioinformatic analysis of SPATA4 gene. J BiochemMol Biol. 38 (6) 739-747 (2005)
48. Qingliu HU, Junlei CHANG, Litao TAO, Guoliang YAN, Mingchao XIE, Zhao WANG*: Endoplasmic reticulum mediated necrosis-like apoptosis of Hela cells induced by Ca2+ oscillation. J BiochemMol Biol. 38 (6) 709-716 (2005)
49. Ying Zhao, Hong Guan, Shang-Feng Liu, Rong-Cong Wu, Zhao Wang*: Overexpression of QM Induces Cell Differentiation and Mineralization in MC3T3-E1. Biological & Pharmaceutical Bulletin.28 (8) 1371-1376 (2005)
50. Shang-Feng Liu, Bo-Wen Liu, Shan He, Ying Zhao, Zhao Wang*: Cloning and characterization of zebrafish SPATA4 gene and analysis of its gonad specific expression. Biochemistry (Moscow). 70 (6) 79-90(2005)
51. Mingjie Liu, Zhao Wang*, Suqin Sun, Qingyu Wu: Monitoring all-trans-retinoic acid-induced differentiation of HL-60 cells by Fourier-transform infrared spectroscopy. Spectroscopy and Spectral Analysis. 25 (5) 688-692 (2005)
52. Ming-Jie Liu, Patrick Ying-Kit Yue, Zhao Wang and Ricky Ngok-Shun Wong: Methyl protodioscin induces G2/M arrest and apoptosis in K562 cells with the hyperpolarization of mitochondria. Cancer Letters. 224 (2) 229-241 (2005)
53. Bowen Liu, Shangfeng Liu, Shan He, Ying Zhao, Hongxia Hu, Zhao Wang*: Cloning and expression analysis of gonadogenesis associated SPATA4 gene from rainbow trout (Oncorhynchusmykiss). J BiochemMol Biol. 38 (2) 206-210 (2005)
54. Ming-JieLiu, Zhao Wang*, Yong Ju, Ricky Ngok-Shun Wong, Qing-Yu Wu: Diosgenin induces cell cycle arrest and apoptosis in human leukemia K562 cells with the disruption of Ca2+ homeostasis. Cancer Chemotherapy and Pharmacology. 55 (1) 79-90 (2005)
55. Zhao Wang*, Peilin ZHANG, Yong JU: Effect of Leonurine on the Activity of Creatine Kinase. Journal of Asian Natural Products Research.6 (4) 281-287 (2004)
56. Shang-Feng Liu, Shan He, Bo-Wen Liu, Zhao Wang*: Cloning and characterization of testis-specificspermatogenesis associated gene homologous to human SPATA4 in rat. Biological & Pharmaceutical Bulletin.27 (11) 1867-1870 (2004)
57. Rong-Cong Wu, Zhao Wang*, Ming-Jie Liu, Di-Fei Chen, Xiao-Shan Yue: 2-integrins mediate a novel form of chemoresistance in cycloheximide-induced U937 apoptosis. Cellular and Molecular Life Sciences. 61 (16) 2071-2082 (2004)
58. YiZongchun, ZhangMin, Fu Juanlin, Wang Zhao，ZhouZongcan: Down-Regulation of Mitotic Checkpoint Function in Transformed Human Embryo Lung FibroblastsInduced by N-Methyl-N’-nitro-N-nitrosoguaridine. Chinese Medical Journal. 117 (7)1079-1083 (2004)
59. Rongcong Wu, Difei Chen, Ming-Jie Liu, Zhao Wang*: Dual Effects of Cycloheximide on U937 Apoptosis Induced by Its Combination with VP-16. Biological & Pharmaceutical Bulletin. 27 (7) 1075-1080 (2004)
60. Ming-JieLiu, Zhao Wang*, Yong Ju, Jiangbing Zhou, Yu Wang, Ricky Ngok-Shun Wong:The Mitotic-Arresting and Apoptosis-Inducing Effects of DiosgenylSaponins on Human Leukemia Cell Lines. Biological & Pharmaceutical Bulletin. 27 (7) 1059-1064 (2004)
61. Shangfeng Liu, Luyun Li, Liu Gang, Xiaowei Xing, Guangxiu Lu, Zhao Wang*: Cloning of a full length cDNA of human testis-specific spermatogenic cell apoptosis inhibitor TSARG2 as candidate oncogene. Biochemical and Biophysical Research Communications (BBRC). 319, 32-40 (2004)
62. Hongjun Zhang, Zhao Wang*, Jiangbing Zhou: Cytoplasm Prepared from All-trans Retinoic Acid (ATRA)-Treated Human Hematopoietic Progenitor Cells Induces Differentiation of Both ATRA Sensitive and ATRA Resistant Leukemia Cells. Biological & Pharmaceutical Bulletin. 27 (4) 570-573 (2004)
63. Zongchun Yi, Zhao Wang*, Haixia Li, Mingjie Liu: Inhibitory Effect of Tellimagrandin I on Chemically Induced Differentiation of Human Leukemia K562 Cells. Toxicology Letter. 147 (2) 109-119 (2004)
64. Zongchun Yi, Zhao Wang*, Haixia Li, Mingjie Liu, Rongcong Wu, Xiaohui Wang: Effects of Chebulinic Acid on Differentiation of Human Leukemia K562 Cells. ActaPharmacologicaSinica. 25 (2)231-238 (2004)
65. Ming-Jie Liu, Zhao Wang*, Hai-Xia Li, Rong-Cong Wu, Yan-Ze Liu, Qing-Yu Wu: Mitochondrial dysfunction as an early event in the process of apoptosis induced by Woodfordin I in human leukemia K562 cells. Toxicology and Applied Pharmacology. 194 (2) 141-155 (2004) (cover)
66. Yong Zhang, Jie Huang, QingxiongMeng, Tiemin, Jiang, LipingXie, Zhao Wang, Rongqing Zhang: Molecular Cloning and Expression of a Pearl Oyster (Pinctadafucata) Homologue of a Mammalian Putative Tumor Suppressor QM. Marine Biotechnology. 6 (1) 8-16 (2004)
67. Mingjie Liu, Zhao Wang*, Rongcong Wu, Suqin Sun, Qingyu Wu: Monitoring all-trans-retinoic acid-induced differentiation of human acute promyelocytic leukemia NB4 cells by Fourier-transform infrared spectroscopy. Leukemia. 17 1670-1674 (2003)