基本情况
刘接卿,副教授,华侨大学生物医学学院药学系主任,理学博士,硕士研究生导师。
研究领域
天然资源尤其是中草药中新颖活性成分的提取分离和结构鉴定、从天然产物中寻找药物先导和候选结构、具有重要生物活性天然产物的结构修饰和作用机制研究、天然产物活性分子的分子探针合成及作用靶标研究。
教育背景
2006年9月至2009年7月,首都师范大学生命科学院,遗传学博士;
2003年9月至2006年7月,吉林大学药学院,药物化学硕士;
1999年9月至2003年7月,吉林大学药学院,药学学士。
工作经历
2015年1月至今,华侨大学生物医学学院,副教授;
2013年1月至2014年12月,中国科学院昆明植物研究所,副研究员;
2012年1月-2012年12月,中国科学院昆明植物研究所,助理研究员;
2009年8月至2011年12月,中国科学院昆明植物研究所,博士后,合作导师邱明华研究员。
科研项目
在科研方面一直致力于中草药活性物质基础和相关活性作用机理研究,到目前为止已分离鉴定和活性筛选了500余个化合物,取得了多项天然药物研究成果:从小桐子中筛选出了具有抗肿瘤活性的候选化合物;从闽产灵芝中发现抗过敏活性的芳香杂萜类分子;从“维生素C之王”针叶樱桃中发现具有抑制AChE活性的新颖结构等。基本阐明抑制前列腺癌增殖和转移的候选药物CurA的分子作用机制和靶标确证工作,正进行临床前药学其他方面的研究工作;已发现对乳腺癌具有良好抑制作用的天然先导化合物分子JQ222,正进行构效关系和作用机制研究。已在天然产物化学和食品化学领域如Organic Letters, Phytochemistry, Planta Medica, Tetrahedron, Journal
of Agricultural and Food Chemistry, Food Chemistry等国际杂志上发表和参与发表SCI论文30余篇。
荣誉奖励
2014年01月入选第十六批云南省中青年学术和技术带头人后备人才;
2014年11月入选龙岩市首批创新人才。
论文发表
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Liu,
J.-Q.; Yang, Y.-F.; J.-J; Li, X.-Y; Li,Z.-R; Zhou, L.; Qiu, M.-H*. Cytotoxic
diterpenoids from Jatropha curcas cv. Nigroviensrugosus CY Yang roots.
Phytochemistry, 117, 462‒468, 2015
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Liu,
J.-Q.; Deng, Y.-Y.; Li, Y.; Li, T.-Z.; Han, Q.; Qiu, M.-H.*, Three New
Tetranorditerpenes from Aerial Parts of Acerola Cherry (Malpighia emarginata).
Molecules, 19 (2), 2629-36, 2014
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Li X.-Y,
Yang Y.-F, Peng X.-R, Li M.-M, Li L.-Q, Deng X, Qin H.-B*, Liu J.-Q*, Qiu M.-H*.
One-Step Semisynthesis Method of Spirocurcasone and Pyracurcasone from
Curcusones A and B. Organic Letters, 12(8),2196-2199, 2014
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Liu,
J.-Q.; Yang, Y.-F.; Li, X.-Y.; Liu, E.-Q.; Li, Z.-R.; Zhou, L.; Li, Y.; Qiu,
M.-H.*,Cytotoxicity of naturally occurring rhamnofolane diterpenes from
Jatropha curcas.Phytochemistry (Elsevier), 96, 265-272, 2013
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Liu,
J.-Q.; Peng, X.-R.; Zhang, W.-M.; Shi, L.; Li, X.-Y.; Chen, J.-C.; Qiu, M.-H.*,Swietemahalactone,
a rearranged phragmalin-type limonoid with anti-bacterial effect, fromSwietenia
mahagoni. RSC Advances, 3, (15), 4890-4893, 2013
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Liu,
J.-Q.; Peng, X.-R.; Li, X.-Y.; Li, T.-Z.; Zhang, W.-M.; Shi, L.; Han, J.;
Qiu,M.-H.*,Norfriedelins A-C with acetylcholinesterase inhibitory activity from
acerola tree(Malpighia emarginata). Organic Letters, 15, (7), 1580-1583, 2013
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Liu,
J.-Q.; Yang, Y.-F.; Wang, C.-F.; Li, Y.; Qiu, M.-H.*, Three new diterpenes
fromJatropha curcas. Tetrahedron, 68, (4), 972-976, 2012
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Liu,
J.-Q.; Wang, C.-F.; Li, Y.; Luo, H.-R.; Qiu, M.-H.*, Isolation and
bioactivityevaluation of terpenoids from the medicinal fungus Ganoderma
sinense. Planta Medica,78, (4), 368-376, 2012
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Liu,
J.-Q.; Wang, C.-F.; Li, Y.; Chen, J.-C.; Zhou, L.; Qiu, M.-H.*, Limonoids
fromthe leaves of Toona ciliata var. yunnanensis. Phytochemistry (Elsevier),
76, 141-149, 2012
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Liu,
J.-Q.; Wang, C.-F.; Chen, J.-C.; Qiu, M.-H.*, Limonoids from the leaves
ofSwieteniamacrophylla. Natural Product Research, 26, (20), 1887-1891, 2012
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Liu,
J.-Q.; Wang, C.-F.; Peng, X.-R.; Qiu, M.-H.*, New alkaloids from the
fruitingbodies of Ganoderma sinense. Natural Products and Bioprospecting, 1,
(2), 93-96, 2011
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Liu,
J.-Q.; Wang, C.-F.; Li, X.-Y.; Chen, J.-C.; Li, Y.; Qiu, M.-H.*, One
newpregnane glycoside from the seeds of cultivated Brucea javanica. Archives of
PharmacalResearch, 34, (8), 1297-1300, 2011
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Liu,
J.-Q.; Chen, J.-C.; Wang, C.-F.; Qiu, M.-H.*, One new cucurbitane triterpenoid
from the fruits of Momordica charantia. European Journal of Chemistry, 1, (4),
294-296, 2010
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Liu,
J.-Q.; Wang, C.-F.; Chen, J.-C.; Tu, S.-H.; Gu, H.-F.; Hu, W.-X.; Qiu, M.-H.*,
Six New Triterpenoid Glycosides from Gynostemma pentaphyllum. Helvetica Chimica
Acta 92, (12), 2737-2745, 2009
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Liu,
J.-Q.; Chen, J.-C.; Wang, C.-F.; Qiu, M.-H., New cucurbitane triterpenoids and
steroidal glycoside from Momordica charantia. Molecules 14, (12), 4804-4813,
2009
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Peng,
X.-R.; Liu, J.-Q.; Wang, C.-F.; Li, X.-Y.; Shu, Y.; Zhou, L.; Qiu, M.-H.*,
Hepatoprotective Effects of Triterpenoids from Ganoderma cochlear. Journal of Natural
Products,77(4), 737-743, 2014
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Peng, X.-R.;
Liu, J.-Q.; Xia, J.-J.; Wang, C.-F.; Li, X.-Y.; Deng, Y.; Bao, N.-M.; Zhang, Z.-R.;
Qiu, M.-H.*, Lanostane triterpenoids from Ganoderma hainanense J. D. Zhao.
Phytochemistry,114, 137-245, 2014
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Peng, X..-R.;
Liu, J.-Q.; Wang, C.-F.; Han, Z.-H.; Shu, Y.; Li, X.-Y.; Zhou, L.; Qiu, M.-H.*,
Unusual prenylated phenols with antioxidant activities from Ganoderma cochlear.
Food chemistry, 171, 251-257, 2015
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Zhao,
G.-T.; Liu, J.-Q.; Deng, Y.-Y.; Li, H.-Z.; Chen, J.-C.; Zhang, Z.-R.; Zhou, L.;
Qiu, M.-H.*, Cucurbitane-Type Triterpenoids from the Stems and Leaves of
Momordica charantia. Fitoterapia, 96, 79-82, 2014
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Shu, Y.;
Liu, J.-Q.; Peng, X.-R.; Wan, L.-S.; Zhou, L.; Zhang, T.; Qiu, M.-H.*,
Characterization of diterpenoid glucosides in roasted Puer coffee bean. Journal
of Agricultural and Food Chemistry, 62 (12), 2631–2637, 2014
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Hu, K.; Liu,
J.-Q.; Li, X.-N.; Chen, J.-C.; Zhang, W.-M.; Li, Y.; Li, L.-Q.; Guo,L.-L.; Ma,
W.-G.; Qiu, M.-H.*, Chukfuransins A-D, Four new phragmalin limonoids with-furan
ring involved in skeleton reconstruction from Chukrasia tabularis.
OrganicLetters, 15, (15), 3902-3905, 2013
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Peng,
X.-R.; Liu, J.-Q.; Han, Z.-H.; Yuan, X.-X.; Luo, H.-R.; Qiu, M.-H.*,Protective
effects of triterpenoids from Ganoderma resinaceum on H2O2-induced toxicity
inHepG2 cells. Food Chemistry, 141, (2), 920-926, 2013
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Wang,
H.-W.; Liu, J.-Q.; Chen, J.-X.; Yang, Y.-F.; Yan, Y.-X.; Li, Z.-R.; Qiu,M.-H.*,
New triterpenoids from the kernels of Azadirachta indica. Natural Products
andBioprospecting, 3, (1), 33-37, 2013
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Yang, Y.
F.; Liu, J. Q.; Li, X. Y.; Liu, E. Q.; Li, Z. R.; Qiu, M. H.*, New
terpenoidsfrom the roots of Jatropha curcas. Chinese Science Bulletin, 58,
(10), 1115-1119, 2013
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Yang,
Y.-F.; Liu, J.-Q.; Li, Z.-R.; Li, Y.; Qiu, M.-H.*, New eudesmenoic acidmethyl
esters from the seed oil of Jatropha curcas. Fitoterapia, 89, 278-284, 2013
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Yang,
Y.-F.; Liu, J.-Q.; Shi, L.; Li, Z.-R.; Qiu, M.-H.*, New
jatropholane-typediterpenes fromJatropha curcas cv. Multiflorum CY Yang.
Natural Products andBioprospecting, 3, (3), 99-102, 2013
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Peng, X.
R.; Liu, J. Q.; Wan, L. S.; Li, X. N.; Yan, Y. X.; Qiu, M. H.*, Four new
polycyclic meroterpenoids from Ganoderma cochlear. Organic letters, 16, (20),
5262-5265, 2014
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Yan,
Yu-Xin; Liu, Jie-Qing; Wang, Hong-Wei; Chen, Jin-Xiong; Chen, Jian-Chao; Chen,
Li; Zhou, Lin; Qiu, Ming-Hua; Identification and Antifeedant Activities of
Limonoids from Azadirachta indica; Chemistry & Biodiversity (2015), 12(7),
1040-1046
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Peng,
XingRong; Liu, JieQing; Wang, CuiFang; Han, ZhongHui; Shu, Yi; Li, XuYang;
Zhou, Lin; Qiu, MingHua; Unusual prenylated phenols with antioxidant activities
from Ganoderma cochlear; Food Chemistry (2015), 171, 251-257
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Yan, Yu-Xin;
Liu, Jie-Qing; Chen, Jin-Xiong; Chen, Jian-Chao; Qiu, Ming-Hua; Three new
limonoids from Azadirachta indica; Journal of Asian Natural Products Research
(2015), 17(1), 14-19
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Chen
Jian-Chao; Liu Jie-Qing; Zhou Lin; Qiu Ming-Hua; Lau Clara Bik-San; Chan Judy
Yuet-Wa; Fung Kwok-Pui; Leung Ping-Chung; Xie Ming-Jin; The antigluconeogenic
activity of cucurbitacins from Momordica charantia; Planta medica (2015),
81(4), 327-332
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Jiang,
S.-Y.; Liu, J.-Q.; Xia, J.-J.; Yan, Y.-X.; Qiu, M.-H.*, Five newtetranortriterpenoids
from the seeds of Toona ciliata. Helvetica Chimica Acta, 95, (2),301-307, 2012
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Peng,
X.-R.; Liu, J.-Q.; Xia, J.-J.; Yang, Y.-H.; Qiu, M.-H.*, Two new
triterpenoidsfrom Ganoderma cochlear. Zhongcaoyao, 43, (6), 1045-1049, 2012
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Wang,
C.-F.; Liu, J.-Q.; Yan, Y.-X.; Chen, J.-C.; Lu, Y.; Guo, Y.-H.; Qiu, M.-H.*,
Three new triterpenoids containing four-membered ring from the fruiting body of
Ganoderma sinense. Organic Letters, 12, (8), 1656-1659, 2010
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Cheng,
B.-H.; Chen, J.-C.; Liu, J.-Q.; Zhou, L.; Qiu, M.-H.*, Cucurbitane-type triterpenoids
from Momordica charantia. Helvetica Chimica Acta, 96, (6), 1111-1120, 2013
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Xu,
W.-X.; Chen, J.-C.; Liu, J.-Q.; Zhou, L.; Wang, Y.-F.; Qiu, M.-H.*, Three
newphysalins from Physalis alkekengi var. franchetii. Natural Products and
Bioprospecting,3, (3), 103-106, 2013