基本情况
焦宁,北京大学药学院教授,国家重点实验室副主任。
研究领域
绿色化学:氧气氧化与活化,氧合反应(Oxygenation Reactions), 氮合反应(Nitrogenation
Reactions); 地球丰产过渡金属催化;基于内源性物质进行先导药物发现,通过可控自由基反应、惰性键活化、串联催化等过程寻求生物活性分子合成新途径、新方法,利用简单原料以简洁、高效的合成方法为先导药物发现及构效关系研究服务。
教育背景
2004年至2006年 化学生物学博士后,德国马普煤炭研究所
1999年至2004年 博士,中科院上海有机化学研究所
1995年至1999年 学士,山东大学化学系
工作经历
2012年至今 副主任,天然药物及仿生药物国家重点实验室
2010年至今 教授,北京大学药学院
2007年至2010年 副教授,北京大学药学院
论文发表
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Xiaoqiang
Huang, Xinyao Li, Miancheng Zou, Song Song, Conghui Tang, Yizhi Yuan, and Ning
Jiao*, From Ketones to Esters by a Cu-Catalyzed Highly Selective C(CO)-C(alkyl)
Bond Cleavage: Aerobic Oxidation and Oxygenation with Air, J. Am. Chem.
Soc.2014, 136, 14858-14865
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Feng
Chen, Xiaoqiang Huang, Xinyao Li, Tao Shen, Miancheng Zou, and Ning Jiao*, Dehydrogenative
N-Incorporation: A Direct Approach to Quinoxaline N-Oxides under Mild
Conditions, Angew. Chem. Int. Ed.2014, 53, 10495-10499
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Conghui
Tang and Ning Jiao*, Copper-Catalyzed Aerobic Oxidative C−C
bond Cleavage for C−N Bond Formation: From Ketones to Amides, Angew.
Chem. Int. Ed.2014, 53, 6528-6532. (Hot Paper)
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Yu-Feng
Liang and Ning Jiao*, Transition-Metal Free Highly Efficient C-H Hydroxylation
of Carbonyls with Molecular Oxygen Under Mild Conditions, Angew. Chem. Int.
Ed.2014, 53, 548
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Chun
Zhang, Peng Feng and Ning Jiao*, Cu-Catalyzed Esterification Reaction via
Aerobic Oxygenation and C-C Bond Cleavage: An Approach toα-Ketoesters, J.
Am.Chem.Soc.2013, 135, 15257–15262
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Teng
Wang and Ning Jiao*, TEMPO-catalyzed Aerobic Oxygenation and Nitrogenation of
Olefins via C=C Double Bond Cleavage, J. Am. Chem. Soc.2013, 135, 11692-11695
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Yijin
Su, Xiang Sun, Guolin Wu, and Ning Jiao*, Catalyst-controlled Highly Selective
Coupling and Oxygenation of Olefins: A Direct Approach to Alcohols, Ketones and
Diketones, Angew. Chem. Int. Ed.2013, 52, 9808-9812 (10.1021/anie.201303917)
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Chong
Qin, Peng Feng, Yang Ou, Tao Shen, Teng Wang and Ning Jiao*, Highly Selective
Csp-Csp Bond Cleavage:The Nitrogenation of Alkynes to Amides, Angew. Chem. Int.
Ed.2013, 52, 7850-7854. (Hot Paper)
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Tao
Shen, Teng Wang, Chong Qin, and Ning Jiao*, Ag-catalyzed Nitrogenation of Alkynes:
A Direct Approach to Nitriles via C-C Triple Bond Cleavage, Angew. Chem. Int.
Ed.2013, 52, 6677-6680. (Hot Paper) (Highlighted bySynfact(2013, 9(9), 0949)
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Yuepeng
Yan, Peng Feng, Qing-Zhong Zheng, Yu-FengLiang, Jingfen Lu, and Ning Jiao*, PdCl2and
NHPI Cocatalyzed Csp-H HydroxylationviaDioxygen Activation, Angew. Chem. Int.
Ed.2013, 52, 5827-5831
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Conghui
Tang and Ning Jiao*, Copper-catalyzed C-H Azidation of Anilines under Mild
Conditions, J. Am. Chem. Soc.2012, 134, 18924-18927.(Highlighted bySynform(2013,
02, A21) andSynfact(2013, 9(2), 0207), Highlighted by Angew. Chem. Int. Ed.
10.1002/anie.201302015)
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Xejun
Xu, Chun Zhang, (These two authors contributed equally to this work) and Ning
Jiao*, Cu-mediated Aerobic Oxidative Dehydrogenative Annulation and Oxygenation
of Aldehydes and Amines for Oxazoles via C-H Functionalization and Dioxygen
Activation, Angew. Chem. Int. Ed.2012, 51, 11367–11370(Hot Paper)
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Teng
Wang, Wang Zhou, Hang Yin, Jun-An Ma, and Ning Jiao*, Iron-Facilitated
Oxidative Dehydrogenative C-O Bond Formation via Propargyl Csp3–H
Functionalization, Angew. Chem. Int. Ed.2012, 51, 10823-10826
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Chong
Qin, Tao Shen, Conghui Tang, and Ning Jiao*, FeCl2-promoted Unactivated C-C
Bond Cleavage of Alkylarenes and Polystyrene: Direct Synthesis of Versatile
Arylamines, Angew. Chem. Int. Ed.2012, 51, 6971-6975(Hot Paper)
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Shengtao
Ding, and Ning Jiao*, N, N-Dimethylformamide: A Multipurpose Building Block, Angew.
Chem. Int. Ed.2012, 51, 9226-9237. (review, invited contribution)
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Chong
Qin, Wang Zhou, Feng Chen, Yang Ou, and Ning Jiao*, Iron-catalyzed C-H and C-C
Bond Cleavage: A Direct Approach to Amides from Simple Hydrocarbon Molecules, Angew.
Chem. Int. Ed.2011, 50, 12595-12599
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Feng
Chen, Chong Qin, Yuxin Cui, and Ning Jiao*, Implanting Nitrogen into
Hydrocarbon Molecules via C-H/C-C Bonds Cleavage: The Direct Approach to
Tetrazoles. Angew. Chem. Int. Ed.2011, 50, 11487-11491. (Highlighted
bySynfacts(Synfacts, 2012, 8, 0144.)
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Chun
Zhang, Zejun Xu, Liangren Zhang, and Ning Jiao*, Copper-catalyzed Aerobic
Oxidative Coupling of Aryl Acetaldehydes with Anilines Leading to α-Ketoamides.
Angew. Chem. Int. Ed.2011, 50, 11088-11092. (VIP articles, Frontispiece Paper, Highlighted
byChemCatChem(ChemCatChem, 2012, 4, 175-176)
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Shengtao
Ding, and Ning Jiao*, The Direct Transformation of DMF(N, N-Dimethylformamide)
to -CN: Pd-catalyzed Cyanation of Heteroarenes via C-H Functionalization. J.
Am. Chem. Soc.2011, 133(32), 12374-12377. (Highlighted byOrg. Process Res.
Dev.2011, 15, 1216–1221)
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Chong
Qin, and Ning Jiao*, Iron-Facilitated Direct Oxidative C−H
Transformation of Allylarenes or Alkenes to Alkenyl Nitriles. J. Am. Chem.
Soc.2010, 132, 15893-15895. (Most accessed articles, Highlighted
bySynfacts(Synfacts, 2011, 2, 203)
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Chun
Zhang, and Ning Jiao*, Cu-catalyzed Aerobic Oxidative Dehydrogenative Coupling
of Anilines Leading to Aromatic Azo Compounds using Dioxygen as Oxidant. Angew.
Chem. Int. Ed.2010, 49, 6174-6177. (Most accessed articles)
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Zhuangzhi
Shi, Bo Zhang, Yuxin Cui, and Ning Jiao*, Palladium-Catalyzed Ring-expansion
Reaction of Indoles with Alkynes: From Indoles to Tetrahydroquinoline
Derivatives Under Mild Conditions. Angew. Chem. Int. Ed.2010, 49, 4036-4041.
(Frontispiece Paper, Most accessed articles)
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Chun
Zhang, and Ning Jiao*, Dioxygen Activation at Ambient Conditions: Cu-catalyzed
Oxidative Amidation-Diketonization of Terminal Alkynes Leading to α-Ketoamides.
J. Am. Chem. Soc.2010, 132, 28-29. (Highlighted byOrg. Chem.)
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Zhuangzhi
Shi, Shengtao Ding, Yuxin Cui, and Ning Jiao*, Pd-catalyzed Oxidative
Cycloaromatization of Biaryls with Alkynes Using Dioxygen as Oxidant. Angew.
Chem. Int. Ed.2009, 48, 7895-7898
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Wang
Zhou, Liangren Zhang, and Ning Jiao*, Direct Transformation of Methyl Aromatics
to Aryl Nitriles at Room Temperature. Angew. Chem. Int. Ed.2009, 48, 7094-7097.
(Hot Paper) (Highlighted by “Synform, 2009, A71”, “Org. Chem. Highlights” (2010,
September 27), and “Nature China ”
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Zhuangzhi
Shi, Chun Zhang, Si Li, Delin Pan, Sengtao Ding, Yuxin Cui, and Ning Jiao*, Indoles
from Simple Anilines and Alkynes: Palladium-Catalyzed C-H Activation Using
Dioxygen as the Oxidant. Angew. Chem. Int. Ed.2009, 48, 4572-4576. (Hot Paper, Highlighted
bySynfacts(Synfacts, 2009, 8, 846), and“Nature China ”, Most accessed articles)
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Delin
Pan, Anjun Chen, Yijin Su, Wang Zhou, Si Li, Wei Jia, Juan Xiao, Qingjian Liu, Liangren
Zhang, and Ning Jiao*, Ligand Free Pd-Catalyzed Highly Selective Arylation of
Allylic Esters with Retention of the Traditional Leaving Group. Angew. Chem.
Int. Ed.2008, 47, 4729-4732