基本情况

刘健康，任西安交通大学生命学院院长，生物与技术系主任，线粒体生物医学研究所所长，兼任华东师范大学紫江学者讲座教授，第二军医大学和江苏大学客座教授。


研究领域

营养对衰老及衰老相关疾病在分子细胞生物学水平上的调控研、重点研究自由基生物学与线粒体代谢机制等


教育背景

1994年至1996年 博士后，美国加州大学伯克莱分校分子细胞生物学专业

1986年至1994年 博士，日本岗山大学医学部神经科学专业

1982年至1986年 硕士，中国医科院药物所和化工部天然药物化学专业

1978年至1982年 学士，西安交通大学化学专业


工作经历

2011年至今，院长，西安交通大学生命科学与技术学院

2008年至今，特聘教授、博士生导师、生物工程与技术系主任，西安交通大学

2008年至今，兼职教授，美国肯塔基大学医学院

2006年至2008年，研究副教授，美国加州大学欧文分校

2003年至2008年，研究员，中科院上海生科院营养所

2000年至2006年，助理研究员、副研究员，美国儿童医院奥克兰研究所

1997年至2006年，研究助理教授、副教授，美国加州大学伯克莱分校分子细胞生物学系


论文发表

  1. Zou X, Feng Z, Li Y, Wang Y, Wertz K, Weber P, Chen Y and Liu J: Stimulation of GSH synthesis to prevent oxidative stress-induced apoptosis by hydroxytyrosol in human retinal pigment epithelial cells: Activation of Nrf2 and JNK-p62/SQSTM1 pathways. J. Nutr Biochem (in press), 2011
  2. Yan J, Feng Z, Liu J, Shen W, Wang Y, Wertz K, Weber P, Long J, and Liu J: Enhanced autophagy plays a cardinal role in mitochondrial dysfunction in type 2 diabetic Goto-Kakizaki (GK) rats: Ameliorating effects of (–)-epigallocatechin-3-gallate. J. Nutr Biochem (in press), 2011
  3. Sun M, Qian F, Shen W, Tian C, Hao J, Sun L and Liu J: Protective effects of mitochondrial nutrients on performance and mitochondrial function in exhaustively exercised rats. Scand J Med Sci Sports (in press), 2011
  4. Chowanadisai W., Shenoy S.F., Sharman E., Keen C.L., Liu J, Rucker R.B. Well-functioning cell mitochondria promote good health. Calif Agr 65: 136-140, 2011
  5. Shenoy S.F., Chowanadisai W., Sharman E., Keen C.L., Liu J., Rucker R.B. Biofactors in food promote health by enhancing mitochondrial function. Calif Agr 65: 141-147, 2011
  6. Chen W, Zhu Q, Xia Q, Cao W, Zhao S and Liu J: Scavenging of reactive oxygen species and protection of DNA by fresh and naturally-fermented coconut sap. J Food Biochem (in press), 2011
  7. Hao, J., Shen, W., Yu, G., Jia, H., Li, X., Feng, Z., Wang, Y., Weber, P., Wertz, K., Sharman, E., and Liu J.: Hydroxytyrosol promotes mitochondrial biogenesis and mitochondrial function in 3T3-L1 adipocytes. J Nutr Biochem 2009 Jul 1. [Epub ahead of print]
  8. Gao M, Long J, Li Y, Shah W, Fu L, Liu J, and Wang Y: Mitochondrial decay is involved in BaP-induced cervical damage. Free Radic Biol Med, 49(11): 1735-1745, 2010
  9. Jia H, Liu Z., Li X., Feng Z., Hao J., Li X., Shen W, Zhang H., Gao H, and Liu J: Anti-Parkinsonism activity of high doses of B vitamins in a chronic cellular model and an α-synuclein transgenic Drosophila model. Neurobiol. Aging 31(4): 636-646, 2010
  10. Zhang H, Jia H, Liu JH, ShenW, Ao N, Wang X, and Liu J: Combination of R-a–Lipoic acid and acetyl-L-carnitine prevents mitochondrial dysfunction and oxidative damage in a rotenone-treated human neuroblastoma cellular model of Parkinson’s disease. J Cell Mol Med 14: 33-43, 2010
  11. Cai X, Hao J, Zhang X, Yu B, Ren J, Luo C, Li Q, Huang Q, Li W, Shi, X, and Liu J: The polyhydroxylated fullerene derivative C60(OH)24 protects mice from ionizing radiation-induced immune and mitochondrial dysfunction. Toxicol. Appl. Pharmacol 243(1): 27-34. 2010
  12. Aksenov V, Long J, Lokuge S, Foster JA, Liu J, Rollo CD: Dietary amelioration of locomotor, neurotransmitter, and mitochondrial aging. Exp Biol Med 235: 66-76, 2010
  13. Feng Z, Liu Z, Li X, Jia H, Sun L, Tian C and Liu J: α-Tocopherol is an effective phase II enzyme inducer: Protective effects on acrolein-induced oxidative stress and mitochondrial dysfunction. J Nutr Biochem 21(12): 1222-1231, 2010
  14. Zhu L, Liu Z, Feng Z, Hao J, Shen W, Li X, Sun L, Sharman E, Wang Y, Wertz K, Weber P, Shi, X and Liu J: Hydroxytyrosol protects oxidative damage by simultaneous activation of mitochondrial biogenesis and phase II enzyme systems in retinal pigment epithelial cells. J Nutr  Biochem 21(11): 1089-1098, 2010
  15. Chen W, Liu X, Shi J, Zheng Y, Zhao S and Liu J: Mechanism of DNA damage induced by arecaidine: The role of Cu (II) and alkaline conditions. Food Chem 119: 433-436, 2010
  16. Liu J, Shen W, Zhao B, Wang Y, Wertz K, Weber P, Zhang P: Targeting mitochondrial biogenesis for preventing and treating insulin resistance in diabetes and obesity: Hope from natural mitochondrial nutrients. Adv Drug Deliv Rev 61: 1343-1352, 2009
  17. Long  J., Gao F., Tong L., Cotman CW, Ames BN, and Liu J: Mitochondrial decay in the brains of old rats: Ameliorating effect of alpha-lipoic acid and acetyl-L-carnitine. Neurochem Res 34: 755-763, 2009
  18. Long J, Liu C, Sun L, Gao H, and Liu J: Neuronal mitochondrial toxicity of malonaldehyde: Inhibitory effects on respiratory function and enzyme activities in rat brain mitochondria, Neurochem Res 34: 786-794, 2009
  19. Liu J, and Hiramatsu M: Akitane Mori, the Artistic Neurochemist. Neurochem Res 34: 593-600, 2009
  20. Hao J, Shen W, Ren J, Tian C, Li X, Long J, and Liu J: Mitochondrial nutrients improve immune dysfunction in the type 2 diabetic Goto-Kakizaki rats. J Cell Mol  Med 13, 701-711,2009
  21. Shen W, Hao J, Tian C, Ren J, Yang L, Li X, Luo C, Cotman CW, and Liu J: A combination of nutriments improves mitochondrial biogenesis and function in skeletal muscle of type 2 diabetic Goto–Kakizaki rats. PLoS ONE 3(6): 23-28, 2008
  22. Cai X, Jia H, Liu Z, Hou B, Luo C, Feng Z, Li W, and Liu J: Polyhydroxylated fullerene derivative C60(OH)24 prevents mitochondrial dysfunction and oxidative damage in a MPP+-induced cellular model of Parkinson ’s disease. J Neurosci Res 86: 3622-3634, 2008
  23. Luo C, Long J, and Liu J: An improved spectrophotometric method for a more specific and accurate assay of mitochondrial complex III activity. Clin Chim Acta 395: 38-41, 2008
  24. Jia H, Li X, Gao H, Feng Z, Li XS, Zhao L, Jia X., Zhang H, Liu J: High doses of nicotinamide prevent oxidative mitochondrial dysfunction in a cellular model and improves motor deficit in a Drosophila model of Parkinson’s disease J Neurosci Res  86: 2083-2090, 2008
  25. Li H, Li X, Jia N, Cai Q, Bai Z, Chen R, Song T, Zhu Z, and Liu J: NF-kB regulates prenatal stress-induced cognitive impairment in offspring rats. Behav Neurosci 122: 331-339, 2008
  26. Li X, Liu Z, Luo C, Jia X, Sun L, Hou B, Shen W, Packer L, Cotman CW, and Liu J: Lipoamide protects retinal pigment epithelial cells from oxidative stress and mitochondrial dysfunction. Free Radic Biol Med 44: 1465-1474, 2008
  27. Shen W,  Liu K, Tian C, Yang L, Li X, Packer L, Head E, and Liu J: Protective effects of R-alpha-lipoic acid and acetyl-L-carnitine in MIN6 and isolated rat Islet cells chronically exposed to oleic acid. J Cell Biochem 104: 1232-1243, 2008
  28. Shen W, Liu K, Tian C, Yang L, Li X, Ren J, Packer L, Cotman CW, and Liu J: R-α-Lipoic acid and acetyl-L-carnitine complementarily promote mitochondrial biogenesis in 3T3-L1 adipocytes. Diabetologia 51: 165-174, 2008
  29. Liu J: The effects and mechanisms of mitochondrial nutrient α-lipoic acid on improving age-associated mitochondrial and cognitive dysfunction: an overview. Neurochem Res 33: 194-203, 2008
  30. Ding H, Gao J, Zhu Z, Xiong Y, and Liu J: Mitochondrial dysfunction enhances susceptibility to oxidative stress by down-regulation of thioredoxin in human neuroblastoma cells. Neurochem  Res 33: 43-50, 2008
  31. Liu Z, Sun L, Zhu L, Jia X, Li X, Jia H, Wang Y, Weber P, Long J, and Liu J: Hydroxytyrosol protects retinal pigment epithelial cells from acrolein-induced oxidative stress and mitochondrial dysfunction. J Neurochem103: 2690-2700, 2007