基本情况

熊兵，博士，中国科学院上海药物研究所研究员。


研究领域

生物信息学、化学信息学为基础的药物信息挖掘、计算生物学及结构生物学、药物设计、合成，组合库设计、合成


工作经历

2010年9月至今  研究员，中国科学院上海药物研究所

2005年12月至2010年8月 副研究员，中国科学院上海药物研究所

2003年9月至2005年10月 博士后，加拿大McGill大学


论文发表

  1. Fong DH#, Xiong B#, Hwang J, Berghuis AM. Crystal structures of two aminoglycoside kinases bound with a eukaryotic protein kinase inhibitor. PloS One. 2011 May 9; 6(5): e19589
  2. Shen Q#, Xiong B#, Zheng M, Luo X, Luo C, Liu X, Du Y, Li J, Zhu W, Shen J, Jiang H. Knowledge-based scoring functions in drug design: 2. Can the knowledge base be enriched? J Chem Inf Model. 2011 Feb 28; 51(2): 386-97
  3. Xue M, Zheng M, Xiong B*, Li Y, Jiang H, Shen J. Knowledge-based scoring functions in drug design. 1. Developing a target-specific method for kinase-ligand interactions. J Chem Inf Model. 2010 Aug 23; 50(8): 1378-86
  4. Xiong B, Wu J, Burk DL, Xue M, Jiang H, Shen J. BSSF: a fingerprint based ultrafast binding site similarity search and function analysis server. BMC Bioinformatics. 2010 Jan 25; 11: 47
  5. Yan BB, Xue MZ, Xiong B*, Liu K, Hu DY, Shen JK. ScafBank: a public comprehensive Scaffold database to support molecular hopping. Acta Pharmacol Sin. 2009 Feb; 30(2): 251-8
  6. Xiong B, Liu K, Wu J, Burk DL, Jiang H, Shen J. DrugViz: a Cytoscape plugin for visualizing and analyzing small molecule drugs in biological networks. Bioinformatics. 2008 Sep 15; 24(18): 2117-8
  7. Xiong B, Burk DL, Shen J, Luo X, Liu H, Shen J, Berghuis AM. The type IA topoisomerase catalytic cycle: A normal mode analysis and molecular dynamics simulation. Proteins. 2008 Jun; 71(4): 1984-94
  8. Wu YL, Ai J, Zhao JM, Xiong B, Xin XJ, Geng MY, Xin XL, Jiang HD. Sulfated polymannuroguluronate inhibits Tat-induced SLK cell adhesion via a novel binding site, a KKR spatial triad. Acta Pharmacol Sin. 2011 May; 32(5): 647-54
  9. Fong DH, Lemke CT, Hwang J, Xiong B, Berghuis AM. Structure of the antibiotic resistance factor spectinomycin phosphotransferase from Legionella pneumophila. J Biol Chem. 2010 Mar 26; 285(13): 9545-55
  10. Zhang Z, Meng T, Yang N, Wang W, Xiong B, Chen Y, Ma L, Shen J, Miao ZH, Ding J. MT119, a new planar-structured compound, targets the colchicine site of tubulin arresting mitosis and inhibiting tumor cell proliferation. Int J Cancer. 2011 Jul 1; 129(1): 214-24
  11. Du Y, Li Q, Xiong B, Hui X, Wang X, Feng Y, Meng T, Hu D, Zhang D, Wang M,Shen J. Aromatic beta-amino-ketone derivatives as novel selective non-steroidal progesterone receptor antagonists. Bioorg Med Chem. 2010 Jun 15; 18(12): 4255-68
  12. Meng T, Wang J, Peng H, Fang G, Li M, Xiong B, Xie X, Zhang Y, Wang X, Shen J. Discovery of benzhydrylpiperazine derivatives as CB1 receptor inverse agonists via privileged structure-based approach. Eur J Med Chem. 2010 Mar; 45(3): 1133-9
  13. Zhang Z, Meng T, He J, Li M, Tong LJ, Xiong B, Lin L, Shen J, Miao ZH, Ding J. MT7, a novel compound from a combinatorial library, arrests mitosis via inhibiting the polymerization of microtubules. Invest New Drugs. 2010 Dec; 28(6): 715-28
  14. Zhang J, Xiong B, Zhen X, Zhang A. Dopamine D1 receptor ligands: where are we now and where are we going. Med Res Rev. 2009 Mar; 29(2): 272-94
  15. Zhu YP, Xiao K, Yu HP, Ma LP, Xiong B, Zhang HY, Wang X, Li JY, Li J, Shen JK.Discovery of potent beta-secretase (bace-1) inhibitors by the synthesis of isophthalamide-containing hybrids. Acta Pharmacol Sin. 2009 Feb; 30(2): 259-69
  16. Zhu Y, Xiao K, Ma L, Xiong B, Fu Y, Yu H, Wang W, Wang X, Hu D, Peng H, Li J, Gong Q, Chai Q, Tang X, Zhang H, Li J, Shen J. Design, synthesis and biological evaluation of novel dual inhibitors of acetylcholinesterase and beta-secretase. Bioorg Med Chem. 2009 Feb 15; 17(4): 1600-13
  17. Ling Q, Huang Y, Zhou Y, Cai Z, Xiong B, Zhang Y, Ma L, Wang X, Li X, Li J, Shen J. Illudalic acid as a potential LAR inhibitor: synthesis, SAR, and preliminary studies on the mechanism of action. Bioorg Med Chem. 2008 Aug 1; 16(15): 7399-409