基本情况

刘常宏，博士，南京大学生命科学学院教授。

 

教育背景

1998年至2000年 博士后，南京大学生命科学学院

1995年至1998年 博士，西北农林科技大学

1982年至1989年 硕士，西北农林科技大学

1982年至1989年 学士，西北农林科技大学

 

工作经历

2010年至至今  教授，南京大学生命科学学院

2002年至2003年 高级访问学者，美国国立卫生院（NIH）、肿瘤研究所（NCI）

2001年至2010年 副教授，南京大学生命科学学院

1993年至1994年 高级访问学者，加拿大温尼泊试验站

 

科研项目

国家重点研发计划（2022YFC3204304）“长江黄河等重点流域水资源与水环境综合治理”重点专项2022年度项目申报指南中的“黄河三角洲生态修复与水沙配置技术研究及示范”课题四“黄河三角洲互花米草扩张预警与控制及侵蚀岸线生态稳固技术”. 2022/7- 2026/12。课题负责人

国家自然科学基金(42273077)：洋底深部真菌合成DMSP的途径、机理及生理生态学功能研究，2023/01-2026/12，主持。

江苏省农业科技自主创新资金项目，CX(22)2021，辣椒连作病害控制合成内生细菌群落制剂的创制及应用技术，2022/07-2025/06，主持。

国家自然科学基金重大研究计划——“水圈微生物驱动地球元素循环的机制”（简称“水圈微生物计划”)”培育项目，91951121，洋底深部真菌反硝化产N2新途径及原位作用模拟，2020/01-2022/12，主持。

国家自然科学基金(41973073)：洋底深部极端环境硫酸盐还原真菌的发现及其异化硫酸盐还原机理和原位作用模拟研究，2020/01-2023/12，主持。

国家自然科学基金(31471810)( 2015.01-2018.12)[90.00 万元]：根内定殖的内生解淀粉芽孢杆菌CC09与小麦的互作机制及对Ggt侵染的生防机理.主持

2013年度高等学校博士学科点专项科研基金(20130091110036)(博导类)：海底深部生物圈真菌的分离、鉴定及生物活性研究. Research Fund for the Doctoral Program of Higher Education

国家自然科学基金(31272081)(2013.01-2016.12)[78.00 万元]：生防解淀粉芽孢杆菌 CC09 菌株环脂肽合成酶基因的转录调控机理研究。主持人

江苏省科技支撑计划--农业部分(BE2012372)(2012-2015)[40.00万元]：解淀粉芽孢杆菌CC09菌株与环脂肽联合增效新生防菌剂的研发。负责人

 

荣誉奖励

2007年，“植物内生真菌代谢物研究”获教育部高等学校科学技术奖（自然科学奖）一等奖（第二完成人）

2005年，“民间常用草药成分的分析与功能研究”获教育部提名国家科学技术奖（自然科学奖）一等奖


论文发表

  1. Zhao Mengshi, Dongxue Li, Jie Liu, Jiasong Fang, Changhong Liu. Fungal methane production under high hydrostatic pressure in deep subseafloor sediments. Microorganisms 2024, 12(1), 2160.
  2. Mengshi Zhao, Dongxu Li, Jie Liu, Jiasong Fang, Changhong Liu. Pressure-tolerant survival mechanism of Schizophyllum commune 20R-7-F01 isolated from deep sediments 2 kilometers below the seafloor. Frontiers in Marine Science 2024, 11:1471465.
  3. Muhammad Zain Ul Arifeen, Shoaib Ahmad, Xinwei Wu, Shengwei Hou, Changhong Liu Amino acids could sustain fungal life in the energy-limited anaerobic sediments below the seafloor. Applied and Environmental Microbiology 2024, 90(10):e01279-24.
  4. Hui Xu, Hongye Zheng, Changhong Liu. Methyl Red degradation by a subseafloor fungus Schizophyllum commune 15R-5-F01: efficiency, pathway, and product toxicity. 3 Biotech 2024;14:202.
  5. Xuan Liu, Xinran Wang, Fan Zhou, Yarong Xue, Changhong Liu. Genomic insights into Penicillium chrysogenum adaptation to subseafloor sedimentary environments. BMC Genomics 25, 4 (2024).
  6. Xuan Liu, Xinran Wang, Fan Zhou, Yarong Xue, Xiangyang Yu, Changhong Liu. (2024) Novel insights into dimethylsulfoniopropionate cleavage by deep subseafloor fungi, Science of the Total Environment 93:173057,
  7. Li Y, Feng F, Mu Q, Li M, Ma L, Wan Q, Jousset A, Liu C*, Yu X*. Foliar Spraying of Chlorpyrifos Triggers Plant Production of Linolenic Acid Recruiting Rhizosphere Bacterial Sphingomonas sp. Environ Sci Technol. 2023, 57(45), 17312-17323. 2023 Oct 31. doi: 10.1021/acs.est.3c04593.
  8. Yunan Ma, Mengshi Zhao, Fan Zhou, Xuan Liu, Changhong Liu. Anaerobic production and biosynthesis mechanism of exopolysaccharides in Schizophyllum commune 20R-7-F01, International Journal of Biological Macromolecules 2023;253(Part 6), 127339.
  9. Jiang JP, Liu X, Liao YF, Shan J, Zhu YP, Liu CH. Genomic insights into Aspergillus sydowii 29R-4-F02: unraveling adaptive mechanisms in subseafloor coal-bearing sediment environments. Front Microbiol. 2023;14:1216714.
  10. Wang Z, Lu K, Liu X, Zhu Y, Liu C. Comparative functional genome analysis reveals the habitat adaptation and biocontrol characteristics of plant growth-promoting bacteria in NCBI databases. Microbiol Spectr. 2023;11(3):e0500722.
  11. Jiang JP, Leng S, Liao YF, Liu X, Li DX, Chu C, Yu XY, Liu CH. The potential role of subseafloor fungi in driving the biogeochemical cycle of nitrogen under anaerobic conditions. Sci Total Environ. 2023;897:165374.
  12. Ma Y, Wang Z, Arifeen MZU, Xue Y, Yuan S, Liu C. Structure and bioactivity of polysaccharide from a subseafloor strain of Schizophyllum commune 20R-7-F01. Int J Biol Macromol. 2022;222(Pt A):610-619.
  13. Huang X, Liu X, Xue Y, Pan B, Xiao L, Wang S, Lever MA, Hinrichs KU, Inagaki F, Liu C. Methane production by facultative anaerobic wood-rot fungi via a new halomethane-dependent pathway. Microbiol Spectr. 2022; 10(5): e0170022.
  14. Liu X, Zain Ul Arifeen M, Xue Y, Liu C. Genome-wide characterization of laccase gene family in Schizophyllum commune 20R-7-F01, isolated from deep sediment 2 km below the seafloor. Front Microbiol. 2022;13:923451.
  15. Liu X, Huang X, Chu C, Xu H, Wang L, Xue Y, Arifeen Muhammad ZU, Inagaki F, Liu C. Genome, genetic evolution, and environmental adaptation mechanisms of Schizophyllum commune in deep subseafloor coal-bearing sediments. iScience. 2022;25(6):104417.
  16. Zain Ul Arifeen M, Ma Y, Wu T, Chu C, Liu X, Jiang J, Li D, Xue YR, Liu CH. Anaerobic biodegradation of polycyclic aromatic hydrocarbons (PAHs) by fungi isolated from anaerobic coal-associated sediments at 2.5 km below the seafloor. Chemosphere. 2022;303(Pt 2):135062.
  17. Jiang H, Tsang L, Wang H, Liu C. IFI44L as a forward regulator enhancing host antituberculosis responses. J Immunol Res. 2021;2021:5599408.
  18. Zain Ul Arifeen M, Ma ZJ, Wu S, Liu JZ, Xue YR, Liu CH. Effect of oxygen concentrations and branched-chain amino acids on the growth and development of sub-seafloor fungus, Schizophyllum commune 20R-7-F01. Environ Microbiol. 2021;23(11):6940-6952.
  19. Jiang H, Tsang L, Wang H, Liu C. Loop-mediated isothermal amplification (LAMP) assay targeting RLEP for detection of Mycobacterium leprae in leprosy patients. Int J Infect Dis. 2021;107:145-152.
  20. Zain Ul Arifeen M, Chu C, Yang X, Liu J, Huang X, Ma Y, Liu X, Xue Y, Liu C. The anaerobic survival mechanism of Schizophyllum commune 20R-7-F01, isolated from deep sediment 2 km below the seafloor. Environ Microbiol. 2021;23(2):1174-1185.
  21. Guo Q, Wang Y, Qian J, Zhang B, Hua M, Liu C, Pan B. Enhanced production of methane in anaerobic water treatment as mediated by the immobilized fungi. Water Res. 2021;190:116761.
  22. Wang B, Zhou J, Zhang XY, Yang YS, Liu CH, Zhu HL, Jiao QC. Covalently immobilize crude d-amino acid transaminase onto UiO-66-NH2 surface for d-Ala biosynthesis. Int J Biol Macromol. 2021;175:451-458.
  23. F. Inagaki K.-U, et al. (2015). Exploring deep microbial life in coal-bearing sediment down to-2.5 km below the ocean floor. Science, 349(6246): 420-424
  24. Wang YT, et al. (2015). A brief review of bioactive metabolites Derived from deep-sea fungi. Marine Drugs, 13,4594-4616
  25. WangYT, et al. (2015). Synthesis, biological evaluation, and molecular docking studies of novel 1-benzene acyl-2-(1-methylindol-3-yl)-benzimidazole derivatives as potential tubulin polymerization inhibitors. European Journal of Medicinal Chemistry, 99, 125-137
  26. ZhengYT, et al. (2015). Correlation between electric potential and peristaltic behavior in Physarumpolycephalum. BioSystems, 132, 13-19
  27. Wang XX, et al. (2014). The ecological roles of Bacillus thuringiensis within phyllosphere environments. Chemosphere, 108:258-264
  28. Xue YR, et al. (2014). Application of an Endophytic Bacillus amyloliquefaciens CC09 in field control of Rehmanniaglutinosa root rots disease. Annual Research & Review in Biology,4(14): 2327-2336
  29. Bu YQ, et al. (2014).Enterobacteramnigenus W5: A potential causal agent for Rehmanniaglutinosa replant problem. Allelopathy Journal, 34 (1): 71-80
  30. Zhai CM, et al. (2013).The mechanism of competition between two bloom-forming Microcystis species. Freshwater Biology, 58(9): 1831-1839
  31. Zhang P, et al. (2013).Growth competition between Microcystis aeruginosa and Quadrigulachodatii under controlled conditions. Journal of Applied Phycology, 25: 555-565
  32. Zhang P, et al. (2012). The dynamics of the water bloom-formingMicrocystis aeruginosa and its relationship with biotic and abiotic factors in Lake Taihu, China. Ecological Engineering, 47: 274-277
  33. Zhai CM, et al. (2012). Does Microcystis aeruginosa have quorum sensing? FEMS Microbiology Letter, 336:38-44.
  34. Cheng K, et al. (2010). Synthesis, molecular modeling and biological evaluation of PSB as targeted antibiotics. Bioorganic & Medicinal Chemistry, 18: 2447-2455
  35. Zhao ZZ, et al. (2010). Study of the antifungal activity of Bacillus vallismortis ZZ185 in vitro and identification of its antifungal components. Bioresource Technology, 101: 292-297
  36. Li HQ, et al. (2010). Design and synthesis of novel deoxybenzoin derivatives as FabH inhibitors and anti-inflammatory agents. Bioorganic & Medicinal Chemistry Letters 2010, 20: 2025-2028