基本情况

李胜，山东省医学科学院/山东省肿瘤防治研究院，医学博士，研究员。

 

主要经历

  1. 肿瘤转移机制的研究，以胰腺癌为模型研究了相关信号通路与肿瘤血管生成、淋巴管生成和转移的机制，阐明了肿瘤血管生成、淋巴管生成和转移的一些机制，对肿瘤的治疗具有指导意义。此研究方向先后为首承担973课题1项；国家自然科学基金项目4项；为首承担省科技厅项目4项。为主获国家科学技术进步二等奖2项，中华医学科技进步三等奖1项；为首获省科技进步三等奖4项。在国内外专业期刊发表论文60余篇，其中SCI收录12篇
  2. 疾病致病基因研究，收集多种疾病的家系标本，近期已成功的确定一多并指/趾家系致病基因的新的突变和一神经纤维瘤病新的突变。此研究方向为首承担国家自然科学基金项目1项；发表SCI论文2篇。承担NSFC课题：一个同卵双生双胞胎家系的关键基因定位研究2011.01-2013.12，编号：31071104  

 

研究领域

肿瘤血管生成、淋巴管生成机制

 

论文发表

  1. Cheng F, Ke X, Lv M, Zhang F, Li C, Zhang X, Zhang Y, Zhao X, Wang X, Liu B, Han J, Li Y, Zeng C, Li S. A novel frame-shift mutation of GLI3 causes non-syndromic and complex digital anomalies in a Chinese family. Clin Chim Acta. 2011; 412 (11-12): 1012-7
  2. Cui K, Zhao W, Wang C, Wang A, Zhang B, Zhou W, Yu J, Sun Z, Li S. The CXCR4-CXCL12 Pathway Facilitates the Progression of Pancreatic Cancer Via Induction of Angiogenesis and Lymphangiogenesis. J Surg Res. 2011 Nov; 171 (1): 143-50
  3. Zhao B, Cui K, Wang CL, Wang AL, Zhang B, Zhou WY, Zhao WH, Li S. The chemotactic interaction between CCL21 and its receptor, CCR7, facilitates the progression of pancreatic cancer via induction of angiogenesis and lymphangiogenesis. J Hepatobiliary Pancreat Sci. 2011 May 19
  4. Ming lv, Wenhua Zhao, Lin Yan, Liang Chen, Kai Cui, Jie Gao, Fachang Yu, Sheng Li. Screening for Mutation Site on the Type I Neurofibromatosis Gene in a Family. Childs Nerv Syst. DOI 10.1007/s00381-011-1653-02
  5. Wen-Hua Zhao, Chun-Ying Wang, Wu-Yuan Zhou, Meng Guo, Yan Li, Li-Min Zhao, Fang-Lian Jiao, Ling Li, Sheng Li. A Case Report of Malignant Atrophic Papulosisand Literature Review. EJD. 2009; 19 (2): 193-194
  6. Wang CL, Zhao WH, Yu J, Li S. Fluorescence in situ hybridization analysis of pancreatoblastoma. Pancreas. 2009; 38 (2): 223-4
  7. Zuo-Xing Niu, Chang-Liang Wang, Wen-Hua Zhao, M. M. Ai-juan Tian, Lan-ping Sun, Yu-hui Li, Bo Zhang, Wei-xia Zhong and Sheng Li. The Histological Origin of Solid-Pseudopapillary Neoplasm of the Pancreas. The Open Gastroenterology Journal. 2009; 3: 13-18
  8. Bo Zhang, Chang-Liang Wang, Wen-Hua Zhao, Ming Lv, Chun-Ying Wang, Wei-xia Zhong, Wu-Yuan Zhou, Wen-Sheng Yu, Yan Zhang, Sheng Li. The effection of 5-LOX/COX-2 common inhibitor DHDMBF30 on pancreatic cancer cell Capan2. World J Gastroenterol. 2008; 14 (16): 2494-2500
  9. Wen-Hua Zhao, Ling Li, Bo Zhang, Wei-Dong Zhang, Min Zong, Ji-Dong Tang, Hong-Yu Zhang, Sheng Li. Enhanced CD4+ T Cell Activities and Modulation of Th1/Th2 Lineage Development in Irradiated Tumor-bearing Mice Due to Treatment with the Male Zooid of Antheraea Pernyi Extracts. World J Gastroenterol. 2008; 14 (13): 2094-2099
  10. Zhao Bin, Zhang Hong-Yu, Zhao Wen-Hua, Zhang Bo, Zong Min, Tang Ji-dong, Yu Jin-ming, Li Sheng. Enhanced CD3+/CD4+ T Cell Activities and Modulation of Th1/Th2 Lineage Development in Irradiated Rats Due to Treatment with the Male Zooid of Antheraea Pernyi Extracts. Chin J Cancer Res. 2008; 20 (4): 255-261
  11. Li S, Niu Z, Tian H, Zhang B, Wang F, Yi LH, Yu J. Treatment of advanced hepatocellular carcinoma with gemcitabine plus oxaliplatin. Hepatogastroenterology. 2007; 54 (73): 218-23
  12. Li Sheng, Zhong Weixia, Yi Longhai, et al. Clinical and Biological Analysis of Pancreatoblastoma. Pancreas. 2005; 30 (1): 87-90
  13. Sheng Li, Bo Zhang, Wei-Dong Zhang, et al. Experimental studies on the immune effect of mice by with concentrated liquor from male zooid of Antheraea pernyi. World Journal of Gastroenterology. 2005; 11 (27): 4254-4258
  14. Bo Zhang, Wen-Hua Zhao, Wu-Yuan Zhou, Wen-Sheng Yu, Jin-Ming Yu, Sheng Li. Expression of vascular endothelial growth factors-C and -D correlate with evidence of lymphangiogenesis and angiogenesis in pancreatic adenocarcinoma. Cancer detection and prevention. 2007; 31: 436–442