基本情况

章晓联，武汉大学教授、博士研究生导师，中华医学会武汉市微生物及免疫学会副理事长，武汉市免疫学会副理事长，中国生物化学与分子生物学学会糖复合物专业委员会委员，中华医学会微生物及免疫学会常委，中华医学会微生物及免疫学会青年委员会常务副主委。 “Frontiers in Cellular and Infection Microbiology”杂志的review editor编委; 担任“Infectious Disorders - Drug Targets'” Editorial Board Members,“Open Glycoscience” Editorial Board Members，担任《中国病毒学》、武汉大学学报(英文版)杂志编委。国家杰出青年基金获得者、和国家级“新世纪百千万人才工程”、教育部新世纪优秀人才支持计划获得者。2009年获湖北省自然科学二等奖一项（第一完成人）。武汉大学基础医学院免疫学系，系常务主任，武汉大学珞珈学者特聘教授。近五年主持和参加了国家自然科学基金6项（包括1项重点和1项创新群体）、“973” 课题2项、“国家重大传染病专项” 1项。2010年被Frontiers in Cellular Microbiology杂志聘为编委（Review Editor）；被国家自然科学基金委员会聘任为第十三届生命科学部微生物学评审组成员。

 

研究领域

1. 引起人类重要病原微生物、凝集素和糖基化免疫功能研究

2. 减弱伤寒沙门菌载体的结核或丙肝疫苗、诊断和药物研究

 

主要经历

2002-至今，任武汉大学基础医学院免疫学系主任、教授、博导 ，武汉大学珞珈学者特聘教授

2004年，病毒学国家重点实验室教授、博导

2004年，任湖北省重点实验室免疫研究室主任

2004年，日本福岛医科大学生化系（II）访问研究员

2001，晋升为基础医学院微生物学及免疫学教研室教授

2001，晋升为美国University of Maryland, College Park动物学系，研究专家(Research Specialist)

1997 -2001.2，美国University of Maryland，College Park动物学系博士后

1993-1997年，香港科技大学生物化学系博士

1989-1993年，湖北医科大学微生物及免疫学教研室助教、讲师

 

主要论文

  1. Li DQ, Li Y, Wu X, Li Q, Yu J, Gen J, Zhang XL*. Knockdown of Mgat5 inhibits breast cancer cell growth with activation of CD4+T cells and macrophages. J Immunol. 2008. 180(5)：3158-3165.
  2. Ma Y, Chen H, Wang Q, Luo F, Yan J, Zhang XL*.IL-24 protects against Salmonella t yphimurium infection by stimulating early neutrophil Th1 cytokine production that in turn activate CD8+ T cells, Eur J Immunol. 2009. 39:1-12.
  3. Zhong B, Zhang L, Lei C, Li Y, Mao AP, Yang Y, Wang YY, Zhang XL, Shu HB. The ubiquitin ligase RNF5 regulates antiviral responses by mediating degradation of the adaptor protein MITA. Immunity. 2009.30(3):397-407.
  4. Chen F, Hu Y, Li D, Chen H, and Zhang XL*. CS-SELEX generates high-affinity ssDNA aptamers as molecular probes for Hepatitis C Virus envelope glycoprotein E2. PloS One, 2009, 4 (12):e8142:1-11.
  5. Wang QL, Pan Q, Ma Y, Wang K, Sun P, Liu S, Zhang XL*. An attenuated Salmonella-vectored vaccine elicits protective immunity against Mycobacterium tuberculosis. Vaccine. 2009.27: 6712-6722.
  6. Chen F, Zhao Y, Liu M, Li D, Wu H, Chen H, Zhu Y, Luo F, Zhong J, Zhou Y, Qi Z, Zhang XL*. Functional Selection of Hepatitis C Virus Envelope E2 Binding Peptide Ligand Using Ribosome Display. Antimicrob Agents Chemother. 2010. 54(8): 3355-3364. 
  7. Chen HD, Zhou X, Yu G, Zhao YL, Ren Y, Zhou YD, Li Q, Zhang XL*. Knockdown of core 1 beta 1, 3-galactosyltransferase prolongs skin allograft survival with induction of galectin-1 secretion and suppression of CD8+T cells. J. Clin. Immunol. 2012. 32：820-836.
  8. Pan Q, Chen H, Wang F, Jeza ViT, Hou W, Zhao Y, Xiang T, Zhu Y, EndoY, Fujita T, Zhang XL*. L-ficolin binds to glycoproteins HA and NA and inhibits influenza A virus infection both in vitro and in vivo. J. Innate Immun. 2012. 4：312-324.
  9. Deng M, Feng S, Luo F, Wang S, Sun X, Zhou X*, Zhang XL*. Visual detection of rpoB mutations in rifampin-resistant Mycobacterium tuberculosis using an asymmetrically split peroxidase DNAzyme. J. Clin. Microbiol. 2012. 50: 3443-3450.
  10. Ning N, Pan Q, Zheng F, Teitz-Tennenbaum S, Egenti M, Yet J, Li M, Ginestier C, Wicha MS, Moyer JS, Prince ME, Xu Y, Zhang XL, Huang S, Chang AE, Li Q.Cancer stem cell vaccination confers significant antitumor immunity. Cancer Res. 2012. 72(7):1853-64.
  11. Yilan Hu, Fengling Luo, Junliang Fu, Tielong Chen, Shimin Wu, Yi-Dan Zhou, Xiao-Lian Zhang*. Early increased ficolin-2 concentrations are associated with severity of liver inflammation and efficacy of anti-viral therapy in chronic hepatitis C patients. Scandinavian Journal of Immunology. Scand J Immunol. 2013. 77: 144-150
  12. Liu M, Pan Q, Luo FL, Meyers C, Zhang XL*. Tumor carbohydrate antigens and strategies to develop cancer vaccines and drugs. Wuhan University Journal of Natural Sciences.（EI） February 2013, Volume 18, Issue 1, pp 1-8
  13. Tian T, Xia H, Zhang XL, Zhang X, Guo S, Wang S, Liu S, Xin Zhou X, Meyers C, Zhou X. Title: Highly and simultaneously sensitive detection of multiple miRNAs in serum based on the strand displacement amplification. Article citation: Chem. Commun., 2013. 49:75-77.
  14. Liu M, Wang S, Zhou Y, Xiang T, Dong H, Yang K, Zhang XL*. An iminosugar N-pentafluorobenzyl-1-deoxynojirimycin as a novel potential immunosuppressant for the treatment of Th2-related diseases. Bioorg Med Chem Lett. 2012. 22:564-570.
  15. Zhai Q, Deng M, Xu L, Zhang XL, Zhou X.Promoting the formation of tetramolecular G-quadruplexes under freezing condition. Bioorg Med Chem Lett.2012. 22(2):1142-5.
  16. Zhang, XL (Zhang Xiaolian)2; Zhou, X (Zhou Xiang)1,3; Zhang, LN (Zhang Lina)1 ,Exploring Quaternized Hydroxyethylcellulose as Potential Gene Carriers, CHINESE JOURNAL OF CHEMISTRY  2012. 30 (9) : 2212-2218.
  17. Chen, F (Chen, Fan)1; Zhang, XL (Zhang, XiaoLian)2; Zhou, J (Zhou, Jing)3; Liu, SW (Liu, Shengwu)2; Liu, JY (Liu, Junyan)2 Three Brassica rapa metallothionein genes are differentially regulated under various stress conditions MOLECULAR BIOLOGY REPORTS , 2012. 39 (3)  : 2157-2162.
  18. YunfengMa, Hai-DanChen, YubinWang, QilongWang, YingyingLi, YinglanZhao, Xiao-lianZhang. Interleukin 24 as a novel potential cytokine immunotherapy for the treatment of Mycobacterium tuberculosis infection. Microbes Infect. 2011. 13: 1099-1110.
  19. Chen F, Zhang XL, Zhou J, Liu S, Liu J. Aptamer inhibits Mycotuberculosis (H37Rv) invasion of macrophage. Mol Biol Rep. 2011. DO 10.1007/s11033-011-0963-3
  20. Zhang XL. Complement L-ficolin binds to surface glycans of HCV and HIV and reduces these viral infectivities, and functions as an antiviral opsonin. Glycoconjugate Journal. 2011. 28(5): 222.
  21. Liu J, Ali MA, Shi Y, Zhao Y, Luo F, Yu J, Xiang T, Tang J, Li D, Hu Q, Ho W, Zhang XL*. Specifically binding of L-ficolin to N-glycans of HCV envelope glycoproteins E1 and E2 leads to complement activation. Cell Mol Immunol. 2009.6(4):235-44.
  22. Zhang L, Sun F, Wang Q, Zhou J, Zhang LH, Zhang XL*, Ye XS. 2009. Discovery of iminosugar derivatives with strong IFN-gamma inducing activity.ChemMedChem. 2009.4(5):756-60.