基本情况

焦宁，北京大学药学院教授，国家重点实验室副主任。

   

研究领域

绿色化学：氧气氧化与活化，氧合反应(Oxygenation Reactions), 氮合反应(Nitrogenation Reactions); 地球丰产过渡金属催化；基于内源性物质进行先导药物发现，通过可控自由基反应、惰性键活化、串联催化等过程寻求生物活性分子合成新途径、新方法，利用简单原料以简洁、高效的合成方法为先导药物发现及构效关系研究服务。

 

教育背景

2004年至2006年 化学生物学博士后，德国马普煤炭研究所

1999年至2004年 博士，中科院上海有机化学研究所

1995年至1999年 学士，山东大学化学系

 

工作经历

2012年至今   副主任，天然药物及仿生药物国家重点实验室

2010年至今   教授，北京大学药学院

2007年至2010年 副教授，北京大学药学院

 

论文发表

  1. Xiaoqiang Huang, Xinyao Li, Miancheng Zou, Song Song, Conghui Tang, Yizhi Yuan, and Ning Jiao*, From Ketones to Esters by a Cu-Catalyzed Highly Selective C(CO)-C(alkyl) Bond Cleavage: Aerobic Oxidation and Oxygenation with Air, J. Am. Chem. Soc.2014, 136, 14858-14865
  2. Feng Chen, Xiaoqiang Huang, Xinyao Li, Tao Shen, Miancheng Zou, and Ning Jiao*, Dehydrogenative N-Incorporation: A Direct Approach to Quinoxaline N-Oxides under Mild Conditions, Angew. Chem. Int. Ed.2014, 53, 10495-10499
  3. Conghui Tang and Ning Jiao*, Copper-Catalyzed Aerobic Oxidative C−C bond Cleavage for C−N Bond Formation: From Ketones to Amides, Angew. Chem. Int. Ed.2014, 53, 6528-6532. (Hot Paper)
  4. Yu-Feng Liang and Ning Jiao*, Transition-Metal Free Highly Efficient C-H Hydroxylation of Carbonyls with Molecular Oxygen Under Mild Conditions, Angew. Chem. Int. Ed.2014, 53, 548
  5. Chun Zhang, Peng Feng and Ning Jiao*, Cu-Catalyzed Esterification Reaction via Aerobic Oxygenation and C-C Bond Cleavage: An Approach toα-Ketoesters, J. Am.Chem.Soc.2013, 135, 15257–15262
  6. Teng Wang and Ning Jiao*, TEMPO-catalyzed Aerobic Oxygenation and Nitrogenation of Olefins via C=C Double Bond Cleavage, J. Am. Chem. Soc.2013, 135, 11692-11695
  7. Yijin Su, Xiang Sun, Guolin Wu, and Ning Jiao*, Catalyst-controlled Highly Selective Coupling and Oxygenation of Olefins: A Direct Approach to Alcohols, Ketones and Diketones, Angew. Chem. Int. Ed.2013, 52, 9808-9812 (10.1021/anie.201303917)
  8. Chong Qin, Peng Feng, Yang Ou, Tao Shen, Teng Wang and Ning Jiao*, Highly Selective Csp-Csp Bond Cleavage:The Nitrogenation of Alkynes to Amides, Angew. Chem. Int. Ed.2013, 52, 7850-7854. (Hot Paper)
  9. Tao Shen, Teng Wang, Chong Qin, and Ning Jiao*, Ag-catalyzed Nitrogenation of Alkynes: A Direct Approach to Nitriles via C-C Triple Bond Cleavage, Angew. Chem. Int. Ed.2013, 52, 6677-6680. (Hot Paper) (Highlighted bySynfact(2013, 9(9), 0949)
  10. Yuepeng Yan, Peng Feng, Qing-Zhong Zheng, Yu-FengLiang, Jingfen Lu, and Ning Jiao*, PdCl2and NHPI Cocatalyzed Csp-H HydroxylationviaDioxygen Activation, Angew. Chem. Int. Ed.2013, 52, 5827-5831
  11. Conghui Tang and Ning Jiao*, Copper-catalyzed C-H Azidation of Anilines under Mild Conditions, J. Am. Chem. Soc.2012, 134, 18924-18927.(Highlighted bySynform(2013, 02, A21) andSynfact(2013, 9(2), 0207), Highlighted by Angew. Chem. Int. Ed. 10.1002/anie.201302015)
  12. Xejun Xu, Chun Zhang, (These two authors contributed equally to this work) and Ning Jiao*, Cu-mediated Aerobic Oxidative Dehydrogenative Annulation and Oxygenation of Aldehydes and Amines for Oxazoles via C-H Functionalization and Dioxygen Activation, Angew. Chem. Int. Ed.2012, 51, 11367–11370(Hot Paper)
  13. Teng Wang, Wang Zhou, Hang Yin, Jun-An Ma, and Ning Jiao*, Iron-Facilitated Oxidative Dehydrogenative C-O Bond Formation via Propargyl Csp3–H Functionalization, Angew. Chem. Int. Ed.2012, 51, 10823-10826
  14. Chong Qin, Tao Shen, Conghui Tang, and Ning Jiao*, FeCl2-promoted Unactivated C-C Bond Cleavage of Alkylarenes and Polystyrene: Direct Synthesis of Versatile Arylamines, Angew. Chem. Int. Ed.2012, 51, 6971-6975(Hot Paper)
  15. Shengtao Ding, and Ning Jiao*, N, N-Dimethylformamide: A Multipurpose Building Block, Angew. Chem. Int. Ed.2012, 51, 9226-9237. (review, invited contribution)
  16. Chong Qin, Wang Zhou, Feng Chen, Yang Ou, and Ning Jiao*, Iron-catalyzed C-H and C-C Bond Cleavage: A Direct Approach to Amides from Simple Hydrocarbon Molecules, Angew. Chem. Int. Ed.2011, 50, 12595-12599
  17. Feng Chen, Chong Qin, Yuxin Cui, and Ning Jiao*, Implanting Nitrogen into Hydrocarbon Molecules via C-H/C-C Bonds Cleavage: The Direct Approach to Tetrazoles. Angew. Chem. Int. Ed.2011, 50, 11487-11491. (Highlighted bySynfacts(Synfacts, 2012, 8, 0144.)
  18. Chun Zhang, Zejun Xu, Liangren Zhang, and Ning Jiao*, Copper-catalyzed Aerobic Oxidative Coupling of Aryl Acetaldehydes with Anilines Leading to α-Ketoamides. Angew. Chem. Int. Ed.2011, 50, 11088-11092. (VIP articles, Frontispiece Paper, Highlighted byChemCatChem(ChemCatChem, 2012, 4, 175-176)
  19. Shengtao Ding, and Ning Jiao*, The Direct Transformation of DMF(N, N-Dimethylformamide) to -CN: Pd-catalyzed Cyanation of Heteroarenes via C-H Functionalization. J. Am. Chem. Soc.2011, 133(32), 12374-12377. (Highlighted byOrg. Process Res. Dev.2011, 15, 1216–1221)
  20. Chong Qin, and Ning Jiao*, Iron-Facilitated Direct Oxidative C−H Transformation of Allylarenes or Alkenes to Alkenyl Nitriles. J. Am. Chem. Soc.2010, 132, 15893-15895. (Most accessed articles, Highlighted bySynfacts(Synfacts, 2011, 2, 203)
  21. Chun Zhang, and Ning Jiao*, Cu-catalyzed Aerobic Oxidative Dehydrogenative Coupling of Anilines Leading to Aromatic Azo Compounds using Dioxygen as Oxidant. Angew. Chem. Int. Ed.2010, 49, 6174-6177. (Most accessed articles)
  22. Zhuangzhi Shi, Bo Zhang, Yuxin Cui, and Ning Jiao*, Palladium-Catalyzed Ring-expansion Reaction of Indoles with Alkynes: From Indoles to Tetrahydroquinoline Derivatives Under Mild Conditions. Angew. Chem. Int. Ed.2010, 49, 4036-4041. (Frontispiece Paper, Most accessed articles)
  23. Chun Zhang, and Ning Jiao*, Dioxygen Activation at Ambient Conditions: Cu-catalyzed Oxidative Amidation-Diketonization of Terminal Alkynes Leading to α-Ketoamides. J. Am. Chem. Soc.2010, 132, 28-29. (Highlighted byOrg. Chem.)
  24. Zhuangzhi Shi, Shengtao Ding, Yuxin Cui, and Ning Jiao*, Pd-catalyzed Oxidative Cycloaromatization of Biaryls with Alkynes Using Dioxygen as Oxidant. Angew. Chem. Int. Ed.2009, 48, 7895-7898
  25. Wang Zhou, Liangren Zhang, and Ning Jiao*, Direct Transformation of Methyl Aromatics to Aryl Nitriles at Room Temperature. Angew. Chem. Int. Ed.2009, 48, 7094-7097. (Hot Paper) (Highlighted by “Synform, 2009, A71”, “Org. Chem. Highlights” (2010, September 27), and “Nature China ”
  26. Zhuangzhi Shi, Chun Zhang, Si Li, Delin Pan, Sengtao Ding, Yuxin Cui, and Ning Jiao*, Indoles from Simple Anilines and Alkynes: Palladium-Catalyzed C-H Activation Using Dioxygen as the Oxidant. Angew. Chem. Int. Ed.2009, 48, 4572-4576. (Hot Paper, Highlighted bySynfacts(Synfacts, 2009, 8, 846), and“Nature China ”, Most accessed articles)
  27. Delin Pan, Anjun Chen, Yijin Su, Wang Zhou, Si Li, Wei Jia, Juan Xiao, Qingjian Liu, Liangren Zhang, and Ning Jiao*, Ligand Free Pd-Catalyzed Highly Selective Arylation of Allylic Esters with Retention of the Traditional Leaving Group. Angew. Chem. Int. Ed.2008, 47, 4729-4732