世界肿瘤研究  >> Vol. 3 No. 2 (April 2013)

植物雌激素防治激素依赖性肿瘤研究进展
Research Progress on Prevention and Cure for Hormone-Dependent Neoplasm by Phytoestrogens

DOI: 10.12677/WJCR.2013.32003, PDF, HTML, XML, 下载: 3,027  浏览: 11,188  科研立项经费支持

作者: 柯有甫*, 高文谦, 曾乐谦:香港大学中医药学院,香港;李春香:福建医科大学附属第二医院,泉州;魏克民, 郑军献:浙江省中医药研究院,杭州

关键词: 植物雌激素雌激素受体雌激素样活性激素依赖性肿瘤中药Phytoestrogen; Estrogen Receptor; Estrogen-Like Activity; Hormone-Dependent Neoplasms; Chinese Materia Medica

摘要: 探究植物雌激素防治激素依赖性肿瘤的文献发现:植物雌激素是来源于植物的杂环多酚类天然化合物,包括黄酮类、木脂素类、香豆素类、二苯乙烯类、醌类、三萜类、甾醇类、真菌雌激素类等。其雌激素活性较雌二醇低,有雌激素或抗雌激素双向调节作用,对激素相关性疾病具有广泛防治作用。实验与临床研究显示:植物雌激素对乳腺癌、卵巢癌、子宫内膜癌、前列腺癌(包括良性前列腺增生)、结肠癌等激素依赖性肿瘤有防治作用。其机制为直接参与机体的内分泌调节、抗氧化、抑制肿瘤血管新生、抑制肿瘤转移、抑制癌基因表达、促进抑癌基因表达、诱导肿瘤细胞凋亡、抑制肿瘤生长与增殖等。含植物雌激素的中药很多,植物雌激素防治激素依赖性肿瘤应用前景广阔。 Through exploring literatures about prevention and cure for hormone-dependent neoplasm by phytoestrogens we found that: Phytoestrogens are plant-derived polyphenolic natural heterocyclic compounds including flavones, lignans, coumarins, stilbenes, quinones, triterpenoids, sterols, mycoestrogen and so on. Phytoestrogens have both estrogenic and anti-estrogenic activity, with a two-way regulation ability and extensive preventive and therapeutic effects on hormone-related diseases. Experimental and clinical studies have shown that phytoestrogens can prevent and treat hormone-dependent neoplasms such as breast cancer, ovarian cancer, endometrial cancer, prostate cancer (including benign prostatic hyperplasia), colon cancer and so forth. Its anti-tumor mechanisms are: directly involving in the body’s endocrine regulation, anti-oxidizing, inhibiting tumor angiogenesis and metastasis, repressing oncogene expression, promoting anti-oncogene expression, inducing tumor cell apoptosis, inhibiting tumor growth and proliferation and so on. There are many Chinese materia medica containing phytoestrogens, which are promising chemoprevention and treatment for hormone-dependent neoplasms.

文章引用: 柯有甫, 高文谦, 曾乐谦, 李春香, 魏克民, 郑军献. 植物雌激素防治激素依赖性肿瘤研究进展[J]. 世界肿瘤研究, 2013, 3(2): 13-16. http://dx.doi.org/10.12677/WJCR.2013.32003

参考文献

[1] M. K. Virk-Baker, T. R. Nagy and S. Barnes. Role of phytoe- strogens in cancer therapy. Planta Medica, 2010, 76(11): 1132- 1142.
[2] D. F. Romagnolo, O. I. Selmin. Flavonoids and cancer prevention: A review of the evidence. Journal of Nutrition in Gerontology and Geriatrics, 2012, 31(3): 206-238.
[3] M. K. Shanmugam, R. Kannaiyan and G. Sethi. Targeting cell signaling and apoptotic pathways by dietary agents: Role in the prevention and treatment of cancer. Nutrition and Cancer, 2011, 63(2): 161-173.
[4] 朱迪娜, 王磊, 王思彤等. 植物雌激素的研究进展[J]. 中草药, 2012, 43(7): 1422-1429.
[5] 赵洁, 侯连兵. 植物雌激素的活性成分及其生物活性研究进展[J]. 中药材, 2005, 28(6): 524-526.
[6] R. J. Miksicek. Estrogenic flavonoids: Structural requirements for biological activity. Experimental Biology and Medicine, 1995, 208(1): 44-50.
[7] Q. S. Li, C. Y. Li and Z. L. Li. Genistein and its synthetic analogs as anticancer agents. Anti-Cancer Agents in Medicinal Chemistry, 2012, 12(3): 271-281.
[8] M. Luijten, A. Verhoef, R. B. Beems, et al. Modulation of mammary tumor development in Tg.NK(MMTV/c-neu) mice by dietary fatty acids an life stage-specific exposure to phyto- estrogens. Reproductive Toxicology, 2007, 23(3): 407-413.
[9] L. N. Anderson, M. Cotterchio, B. A. Boucher, et al. Phyto- estrogen intake from foods, during adolescence and adulthood, and risk of breast cancer by estrogen and progesterone receptor tumor subgroup among Ontario women. International Journal of Cancer, 2013, 132(7): 1683-1692.
[10] S. A. Lee, X. O. Shu, H. L. Li, et al. Adolescent and adult soy food intake and breast cancer risk: Results from the Shanghai women’s health study. The American Journal of Clinical Nu- trition, 2009, 89(6): 1920-1926.
[11] K. Buck, A. K. Zaineddin, A. Vrieling, et al. Meta-analyses of lignans and enterolignans in relation to breast cancer risk. The American Journal of Clinical Nutrition, 2010, 92(1): 141-153.
[12] W. H. Xu, W. Zheng, Y. B. Xiang, et al. Soya food intake and risk of endometrial cancer among Chinese women in Shanghai: Population based case-control study. British Medical Journal, 2004, 328(7451): 1285-1289.
[13] H. A. Ward, G. G. Kuhnle, A. A. Mulligan, et al. Breast, colorectal, and prostate cancer risk in the European Prospective Inves- tigation into Cancer and utrition-Norfolk in relation to phy- toestrogen intake derived from an improved database. The American Journal of Clinical Nutrition, 2010, 91(2): 440-448.
[14] X. Wang, E. A. Clubbs and J. A. Bomser. Genistein modulates prostate epithelial cell proliferation via estrogen and extra- cellular signal regulated kinase-dependent pathways. The Jour- nal of Nutritional Biochemistry, 2006, 17(3): 204-210.
[15] T. Chiyomaru, S. Yamamura, S. Fukuhara, et al. Genistein up- regulates tumor suppressor MicroRNA-574-3p in prostate cancer. PLoS One, 2013, 8(3): e58929.
[16] Y. Feng, X. Y. Xia and Y. F. Huang. Effects of phytoestrogens on prostate cancer and benign prostatic hyperplasia. Zhonghua Nan Ke Xue, 2007, 13(5): 457-461.
[17] H. Nakagawa, D. Yamamoto, Y. Kiyozuka, et al. Effects of genistein and synergistic action incombination with eicosa- pentaenoic acid on the growth of breast cancer cell lines. Journal of Cancer Research and Clinical Oncology, 2000, 126(8): 448- 454.
[18] A. I. Constantinou, A. E. Krygier and R. R. Mehta. Genistein induces maturation of cultured human breast cancer cells and prevents tumor growth in nude mice. The American Journal of Clinical Nutrition, 1998, 68(6): 1426S-1430S.
[19] R. C. Santell, N. Kieu and W. G. Helferich. Genistein inhibits growth of estrogen-independent human breast cancer cells in culture but not in athymic mice. Journal of Nutrition, 2000, 130(7): 1665-1669.
[20] T. Usui. Pharmaceutical prospects of phytoestrogens. Endocrine Journal, 2006, 53(1): 7-20.
[21] 余增丽, 张立实, 李群英等. 大豆异黄酮和玉米赤霉烯酮对卵巢癌细胞株PEO4增殖的影响[J]. 中华预防医学杂志, 2003, 37(3): 154-156.
[22] A. Bielecki, J. Roberts and R. Mehta. Estrogen receptor-β mediates the inhibition of DLD-1 human colon adenocarcinoma cells by soy isoflavones. Nutrition and Cancer, 2011, 63(1): 139- 150.
[23] C. Sebastiano, F. Vincenzo, C. Tommaso, et al. Dietary patterns and prostatic diseases. Frontiers in Bioscience (Elite Edition), 2012, 4: 195- 204.
[24] L. Frémont. Biological effects of resveratrol. Life Sciences, 2000, 66(8): 663- 673.
[25] 徐德平, 江汉湖, 汤涛等. 大豆及丹贝异黄酮对乳腺癌、子宫癌和卵巢癌细胞的抑制效应[J]. 食品科学, 2001, 22(6): 691- 695.
[26] K. S. Weber, K. D. Setchell, D. M. Stocco, et al. Dietary soy phytoestrogens decrease testosterone levels and prostate weight without altering LH, prostat 5alpha-reductase or testicular ster- oidogenic acute regulatory peptide levels in adult male Sprague- Dawley rats. Journal of Endocrinology, 2001, 170(3): 591-599.
[27] C. A. Lamartiniere, M. S. Cotroneo, W. A. Fritz, et al. Genistein chemo prevention: timing and mechanisms of action in murine mammary and prostate. Journal of Nutrition, 2002, 132(35): 552-558.
[28] H. Chang, Q. Xie, Q. Y. Zhang, et al. Flavonoids, flavonoid subclasses and breast cancer risk: A meta-analysis of epide- miologic studies. PLoS One, 2013, 8(1): e54318.