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分析化学进展  >> Vol. 4 No. 2 (May 2014)

基于GC-MS的代谢组学方法筛选肺癌标志物的分析流程与研究进展
Recent Development of GC-MS-Based Analytical Procedures of Metabolomics in Screening of Lung Cancer Biomarkers

DOI: 10.12677/AAC.2014.42003, PDF, HTML, 下载: 3,225  浏览: 14,046  科研立项经费支持

作者: 李彩霞, 张佩佩, 王利超, 刘会君, 潘再法, 王丽丽：浙江工业大学化学工程学院，杭州

关键词: 气相色谱–质谱联用；代谢组学；肺癌标志物；Gas Chromatography-Mass Spectrometry (GC-MS)； Metabolomics； Lung Cancer Biomarkers

摘要: 完整的代谢组学分析流程包括样本的采集与前处理、代谢组数据的采集和获取、数据的处理与分析、标志物的识别与生物学阐释等步骤。本文依据代谢组学的分析流程综述了基于GC-MS的代谢组学方法筛选肺癌标志物的研究流程及进展，并对GC-MS分析技术在代谢组学研究中存在的问题进行了总结与展望。
Abstract: The complete analytical procedures of metabolomics include sample collection and pretreatment, metabolomic data collection and acquisition, data processing and analysis, as well as markers identification and biological interpretation. In this context, the review deals with the current development and further trends in the discovery of lung cancer biomarkers based on GC-MS analytical procedures of metabolomics.

文章引用: 李彩霞, 张佩佩, 王利超, 刘会君, 潘再法, 王丽丽. 基于GC-MS的代谢组学方法筛选肺癌标志物的分析流程与研究进展[J]. 分析化学进展, 2014, 4(2): 11-19. http://dx.doi.org/10.12677/AAC.2014.42003

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